Catalog No.
Product Name
Application
Product Information
Citations
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Antifungal Potentiator
Polygodial is a sesquiterpene known for its role as an antifungal potentiator. It exhibits significant anti-hyperalgesic properties, making it a valuable compound in research focused on pain modulation and fungal infections. Polygodial has potential applications in developing therapeutic strategies targeting antifungal resistance and enhancing pain relief mechanisms. -
Fluxapyroxad Metabolite
M700F048 is a primary metabolite of the fungicide Fluxapyroxad, targeting the inhibition of succinate dehydrogenase in fungal respiration. This compound is essential for studying the metabolic pathways and environmental behavior of Fluxapyroxad. It has significant applications in toxicological research and understanding the efficacy and degradation of fungicides in agricultural settings. -
Fungicide
Propiconazole is a triazole compound primarily used as a fungicide, targeting fungal sterol biosynthesis by inhibiting the enzyme lanosterol demethylase. Its biological activity is characterized by effective control over various fungal pathogens in agricultural applications. However, it has been identified as a hepatotoxicant and hepatocarcinogen in experimental models, with reported adverse effects on reproduction and development in animals. This information is critical for researchers in toxicology and agricultural sciences assessing the safety and efficacy of fungicidal agents. -
Triazole Fungicide
Difenoconazole is a triazole fungicide that acts as a sterol demethylation inhibitor. It selectively binds to the heme group of fungal cytochrome P450 51, disrupting mycelial growth and inhibiting spore germination. This compound is utilized in research applications focused on pathogenic fungi, offering insights into fungal growth mechanisms and resistance management strategies. -
Antibiotic
Tigecycline mesylate is a broad-spectrum glycylcycline antibiotic that targets bacterial protein synthesis. It exhibits significant inhibitory activity against various Gram-positive and Gram-negative bacteria, with a mean inhibitory concentration (MIC) for E. coli (MG1655 strain) of approximately 125 ng/mL. For Acinetobacter baumannii, the MIC50 and MIC90 values are 1 mg/L and 2 mg/L, respectively, making it valuable for research focused on antibiotic resistance and infection control. -
HIV NNRTI
(Rac)-Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1. It demonstrates significant antiviral activity with a Ki of 2.93 nM for the inhibition of the wild-type HIV-1 reverse transcriptase and an IC95 of 1.5 nM against HIV-1 replication in cultured cells. This compound is suitable for research applications focusing on HIV-1 therapy and the development of antiretroviral drugs. -
Parasite Inhibitor
Gallinamide A TFA is a potent inhibitor of cathepsin L (CatL), with an IC50 of 17.6 pM. This peptide demonstrates significant antiviral activity by inhibiting SARS-CoV-2 infection, with an EC50 of 28 nM. Additionally, Gallinamide A TFA effectively inhibits Plasmodium falciparum, exhibiting an IC50 of 50 nM, making it a valuable reagent for research into parasitic infections and viral therapies. -
Anti-parasite Agent
D-Arabinose functions as an anti-parasitic agent with a notable capability to inhibit the growth of Caenorhabditis elegans, exhibiting an IC50 of 7.5 mM. This compound effectively penetrates the blood-brain barrier and selectively interferes with the metabolism of D-ribose and D-fructose. Additionally, D-Arabinose demonstrates antibacterial properties by inhibiting biofilm synthesis and activates the ACSS2-PPARγ/TFEB-CRTC1 axis via the lysosomal AXIN-LKB1-AMPK pathway, contributing to its antidepressant-like effects. D-Arabinose serves as the ring-opened form of the aldopentose D-arabinose. -
PPAR-γ Activator
Glabrone, a PPAR-γ activator derived from the roots of Glycyrrhiza glabra, demonstrates notable ligand binding activity to this nuclear receptor. In addition to its role as a specific probe substrate for UGT1A9, Glabrone's metabolites inhibit neuraminidase, thus preventing influenza virus release. This compound is suitable for research applications focused on herb-drug interactions and the evaluation of anti-influenza viral activity. -
Antibiotic
nTZDpa is a partial agonist of PPARG and functions as an antibiotic. It exhibits significant antibacterial activity, particularly against both growing and persistent strains of Staphylococcus aureus, through the mechanism of lipid bilayer disruption. This compound is valuable for research applications focused on antibiotic resistance and the exploration of novel therapeutic strategies against bacterial infections. -
Antibacterial Agent/Growth-promoting Agent
Quindoxin is an antibacterial agent that acts by disrupting bacterial cell function. It demonstrates significant growth-promoting activity, particularly in livestock, and has been shown to exhibit dose-dependent mutagenicity against Salmonella typhimurium strains TA98 and TA100. Additionally, Quindoxin is associated with potential DNA damage, highlighting its relevance in studies related to genotoxicity and carcinogenicity. -
Bacterial Transcription Inhibitor
GKL003 is a bacterial transcription inhibitor that targets the interaction interface of RNA polymerase (RNAP) and the sigma factor, with a Ki value of 5.79 nM. By specifically binding to the RNAP β' clamp helix region at the σA factor binding site, GKL003 disrupts the formation of the RNAP holoenzyme and inhibits bacterial transcription initiation complexes. This compound effectively inhibits the growth of both Gram-positive and Gram-negative bacterial strains, including those that are drug-resistant, making it a valuable tool for research applications in microbiology and antibiotic resistance studies. -
FXR Antagonist
(-)-(E)-Guggulsterone is a natural stereoisomer of Guggulsterone that functions as a Farnesoid X Receptor (FXR) antagonist with an IC50 of 24.06 μM. This compound exhibits significant hypolipidemic effects and demonstrates the ability to suppress dengue virus (DENV) replication by enhancing antiviral interferon responses through the activation of Nrf2 and upregulation of HO-1 expression. Additionally, (-)-(E)-Guggulsterone displays antibacterial properties against various strains, including Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa, as well as offering cardiac protective and antioxidant benefits in rat models. -
Antibiotic
CPPD-Q is an antimicrobial agent that primarily targets bacterial pathogens. It demonstrates potent antibacterial activity with an EC50 value of 6.98 mg/L against Vibrio fischeri. Additionally, CPPD-Q exhibits insecticidal properties in Caenorhabditis elegans, where it induces the generation of reactive oxygen species (ROS) in the intestines at concentrations of 1 or 10 µg/mL. This compound is suitable for research applications focused on antimicrobial resistance and the mechanisms of insecticidal action. -
Antiviral Agent
Onradivir is an orally active antiviral agent that specifically targets the PB2 subunit of influenza A virus RNA polymerase, exhibiting an IC50 of 0.562 nM. By inhibiting cap binding, Onradivir effectively suppresses viral replication, lowers viral titers, and mitigates influenza A virus infection. In preclinical studies, Onradivir demonstrated enhanced survival rates in mice infected with influenza A virus and significantly reduced viral loads. This compound is valuable for researching influenza A virus infections and developing potential therapeutic strategies. -
RSV Polymerase Inhibitor
JNJ-8003 is a highly potent, orally active non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase, exhibiting an IC50 of 0.29 nM. It specifically targets the L protein of the polymerase complex, effectively blocking the transcription and replication of the viral genome by inhibiting RNA-dependent RNA polymerase (RdRp) activity, with an IC50 of 0.67 nM. In vitro studies demonstrate subnanomolar efficacy, and it has shown significant effectiveness in mouse and neonatal lamb models. JNJ-8003 is a valuable reagent for investigating RSV biology and developing antiviral therapies. -
Purine Nucleoside Analog
2-Thiouridine is a purine nucleoside analog that enhances the stability of U:A base pairs while destabilizing U:G wobble base pairs. This modification significantly boosts the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. Additionally, 2-Thiouridine exhibits notable antiviral activity against a range of positive-sense single-stranded RNA viruses, including Dengue Virus (DENV2), Zika Virus (ZIKV), Yellow Fever Virus (YFV), Japanese Encephalitis Virus (JEV), West Nile Virus (WNV), Chikungunya Virus (CHIKV), and various human coronaviruses, such as SARS-CoV and MERS-CoV. -
Antibiotic
Rifalazil, a rifamycin derivative, targets bacterial DNA-dependent RNA polymerase, specifically inhibiting the β-subunit to disrupt RNA synthesis and induce bacterial cell death. This antibiotic demonstrates exceptional potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, Chlamydia pneumoniae, and Chlamydia trachomatis, with MIC values ranging from 0.00025 to 0.0025 μg/ml. Rifalazil shows promising potential for applications in treating Chlamydia infections, Clostridium difficile-associated diarrhea (CDAD), and tuberculosis (TB). -
Antibiotic
Phleomycin is a copper-dependent antibiotic known for its DNA-damaging properties. It exerts its biological activity by binding to DNA and generating reactive oxygen species (ROS) in the presence of reducing agents, leading to both single-strand and double-strand breaks. This compound is extensively utilized in cancer research, microbial genetic transformation, serving as a screening marker to enhance fungal transformation efficiency, and the study of DNA repair mechanisms. -
HBV Inhibitor
Bersacapavir is an HBV capsid assembly modulator that targets hepatitis B virus (HBV) replication. It exhibits a dual mechanism of action by forming complete genome-free empty capsids and inhibiting the de novo synthesis of covalently closed circular DNA (cccDNA). This compound is valuable for research applications focusing on HBV infection and the development of antiviral therapies. -
Quinolone Antibiotic
Danofloxacin is a quinolone antibiotic that primarily targets bacterial DNA gyrase, leading to the inhibition of DNA replication and transcription. This mechanism disrupts the growth and proliferation of bacteria. Danofloxacin is effective against a range of bacterial infections, including those caused by Escherichia coli, Mycoplasma, and other pathogenic organisms, making it a valuable tool for related research applications. -
DENV Polymerase Inhibitor
NITD-2 is a selective inhibitor of dengue virus (DENV) polymerase, specifically targeting the RNA-dependent RNA polymerase (RdRp) to impede RNA elongation. This compound exhibits potent antiviral activity against DENV, making it a valuable tool for research focused on understanding dengue virus replication and developing therapeutic strategies. Its limited ability to penetrate cell membranes can be an important consideration for in vitro experimental design. -
Macrolide Antibiotic
Erythromycin lactobionate is a macrolide antibiotic that targets bacterial 50S ribosomal subunits, inhibiting RNA-dependent protein synthesis through obstruction of transpeptidation and/or translocation processes. This compound demonstrates a broad spectrum of antimicrobial activity, making it valuable for various bacterial infections. Additionally, erythromycin lactobionate has shown potential antitumor and neuroprotective effects, presenting opportunities for research in oncology and neurobiology. -
HBV RNase H Inhibitor
β-Thujaplicinol is a potent inhibitor of hepatitis B virus (HBV) ribonuclease H, showing inhibitory effects on HBV genotypes D and H with IC50 values of 5.9 and 2.3 μM, respectively. Its primary mechanism involves disrupting the enzymatic activity of HBV RNase H, making it a valuable tool for researching HBV replication and pathogenesis. This compound is suitable for studies focused on antiviral development and the therapeutic targeting of HBV. -
HBV inhibitor
ALG-000184 is an orally bioavailable inhibitor targeting hepatitis B virus (HBV). It functions as a prodrug to ALG-001075 and effectively reduces HBV DNA production in liver cells. This compound is intended for research applications in chronic hepatitis B studies, facilitating investigations into therapeutic strategies against HBV infection.
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Dengue Virus Protease Inhibitor
SP-471P is a potent inhibitor of the dengue virus (DENV) protease, exhibiting EC50 values of 5.9 μM, 1.4 μM, 5.1 μM, and 1.7 μM against DENV1, DENV2, DENV3, and DENV4, respectively, with a CC50 exceeding 100 μM. This compound effectively reduces DENV viral RNA synthesis, making it a valuable tool for research in dengue virus biology and antiviral therapeutic development. -
Antibiotic
Pefloxacin is a broad-spectrum antibiotic that targets DNA gyrase, effectively inhibiting DNA replication. It exhibits significant antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis, with MIC90 values of 0.12, 4, and 16 mg/L, respectively. In addition to its antibacterial properties, Pefloxacin has demonstrated efficacy in reducing Plasmodium yoelii infections and may enhance UVA-induced edema and immunosuppression. This compound is suitable for various infection-related research applications. -
Bacteria Antibiotic
Nogalamycin is an anthracyclinone antibiotic that primarily targets Gram-positive bacteria. It exhibits significant antibacterial activity along with cytotoxic effects against specific tumor cells. Derived from Streptomyces nogalater var. nogalater, Nogalamycin selectively inhibits RNA synthesis by binding to the DNA template. This compound is valuable for research into anticancer therapeutics and bacterial resistance mechanisms. -
HCV Inhibitor
TTP-8307 is a potent HCV inhibitor that disrupts the replication of various rhino- and enteroviruses. It specifically inhibits coxsackievirus B3 (CVB3) with an EC50 value of 1.2 μM, alongside poliovirus, by interfering with viral RNA synthesis. The compound exerts its antiviral effects through interaction with oxysterol-binding protein (OSBP), making it a valuable tool for research in virology and antiviral drug development. -
Antibacterial Agent
Ostruthin is a natural coumarin compound that exerts antibacterial and antimycobacterial activities. It effectively inhibits the growth of mycobacteria and Staphylococcus aureus, making it valuable in studies of bacterial pathogenesis. Additionally, ostruthin suppresses vascular smooth muscle cell proliferation and de novo DNA synthesis, positioning it as a pertinent tool for research related to mycobacterial infections and cardiovascular as well as cerebrovascular diseases. -
HBV Replication Inhibitor
AT-130 is a phenylpropenamide derivative that serves as a potent non-nucleoside inhibitor of hepatitis B virus (HBV) replication. It effectively inhibits viral DNA synthesis, exhibiting an EC50 of 0.13 μM against both wild-type and mutant strains of HBV. AT-130 demonstrates significant anti-HBV activity in hepatoma cell lines, making it a valuable tool for research focused on HBV infection and treatment strategies. -
Ansamycin Antibiotic
Rifamycin is an orally active ansamycin antibiotic that primarily inhibits DNA-dependent RNA synthesis. It demonstrates significant antibacterial activity against Mycobacterium tuberculosis and can also affect hepatic bile acid metabolism. Additionally, Rifamycin exhibits anti-inflammatory properties, making it useful in the study of infections caused by Mycobacterium tuberculosis and Bacteroides fragilis, as well as in research involving lipopolysaccharide-induced inflammation. -
Bacterial Inhibitor
Mequindox is an antimicrobial agent that functions as a bacterial inhibitor by selectively targeting and inhibiting DNA synthesis. This compound demonstrates significant genotoxic and carcinogenic effects in murine models, making it a valuable tool for studying bacterial resistance mechanisms and the potential impacts of antimicrobial agents on genetic material. Its applications extend to research on the safety and efficacy of antimicrobial treatments in various biological systems. -
Bacterial Inhibitor
Silver sulfadiazine is a sulfonamide antibiotic that functions as a bacterial inhibitor through dual mechanisms. The sulfa moiety inhibits bacterial folate absorption, thereby disrupting essential DNA synthesis. Additionally, silver ions released from silver sulfadiazine bind to and disrupt DNA structures, preventing bacterial DNA replication. This compound is widely used in research applications focusing on bacterial growth inhibition and antimicrobial studies. -
HBV Inhibitor
HBV-IN-4 is a phthalazinone derivative that functions as a potent inhibitor of HBV DNA replication, exhibiting an IC50 value of 14 nM. This compound effectively induces the formation of genome-free capsids, demonstrating substantial anti-HBV activity. Its applications include research into therapeutic strategies for hepatitis B virus infections. -
Antibiotic
Holomycin is a secondary metabolite belonging to the dithiolopyrrolone class, recognized for its broad-spectrum antibiotic properties. It exhibits notable antitumor activity and functions by inhibiting RNA synthesis in vivo. Holomycin serves as a valuable tool in pharmaceutical research, particularly in studies related to antimicrobial resistance and cancer therapeutics. -
Antibacterial Agent
Amicoumacin B is an antibacterial agent produced by the actinomycete strain 04-5195T, primarily targeting bacterial quorum sensing mechanisms. It demonstrates significant inhibitory activity against Chromobacterium violaceum, with a minimum inhibitory concentration (MIC) of 250 µg/mL. Additionally, Amicoumacin B upregulates the expression of bone morphogenetic protein 2 (BMP-2) while simultaneously inhibiting the expression of essential quorum sensing operons vioA, vioB, vioD, and vioE, and enhancing vioC expression. These properties make Amicoumacin B a valuable tool in microbiological research and the study of bacterial communication. -
Antibiotic
10,11-Dehydrocurvularin is an antibiotic derived from fungi, known for its ability to activate the heat shock response. This compound exhibits significant inhibition of the TGF-β signaling pathway, demonstrating anti-tumorigenic properties. Its biological activities make it a valuable reagent for research in antibiotic efficacy and cancer biology. -
Antitumor Antibiotic
Dinactin is an antibiotic ionophore derived from Streptomyces species, primarily targeting the Wnt/β-catenin signaling pathway in cancer cells. This compound exhibits significant inhibition of HCT-116 cell proliferation, with an IC50 value of 1.1 μM, demonstrating its anti-proliferative effects in an apoptosis-independent manner. Additionally, Dinactin serves as a valuable tool in research related to neuropathic pain. -
Antitumor Antibiotic
Sibiromycin is a glycosylated pyrrolobenzodiazepine (PBD) that functions as a potent antitumor antibiotic. It exerts its biological activity by covalently binding to DNA in the minor groove, specifically targeting the amino group of guanine. This mechanism contributes to its effectiveness in cancer research, making it a valuable tool for studies involving DNA interactions and antitumor mechanisms. -
Antineoplastic Antibiotic
Cytogenin, an antineoplastic antibiotic, demonstrates significant antitumor activity by inhibiting the growth of Ehrlich ascites tumors in mouse models. This compound also regulates inflammatory cytokines, effectively reducing levels of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and interleukin-6 (IL-6) in murine macrophages. Additionally, Cytogenin exhibits antidiabetic effects, making it a valuable reagent for research in cancer biology and inflammation. -
Larvicide/Antiviral
Cappariloside A is a potent larvicide primarily targeting Aedes aegypti larvae, demonstrating significant larvicidal activity while inhibiting larval glutathione-S-transferase activity. Additionally, it exhibits antiviral effects by decreasing phosphorylated STAT1 levels, inhibiting the replication of various influenza viruses, including H1N1 and H3N2, and downregulating key pro-inflammatory cytokines such as IL-6 and IFN-β. Cappariloside A is valuable for research involving larvicidal strategies and the investigation of antiviral responses in influenza virus infections. -
HSV Inhibitor
Denotivir is an orally active antiviral agent targeting herpes simplex virus (HSV) and varicella-zoster virus (VZV). It exhibits significant inhibition of viral proliferation and demonstrates anti-cancer properties, influencing the growth of various cancer cell lines. Additionally, Denotivir plays a role in immunosuppression by inhibiting the generation of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6, making it relevant for research in virology and oncology. -
HEVA71/PTP1B Inhibitor
Prunin is a potent inhibitor of human enterovirus A71 (HEVA71) and demonstrates strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 5.5 μM. This compound has significant potential for research applications in virology and metabolic disease studies, particularly in elucidating the roles of HEVA71 and PTP1B in cellular signaling pathways and disease mechanisms. -
Bacterial Inhibitor
Fenvalerate is a highly effective bacterial inhibitor, primarily functioning as a protein phosphatase 2B (calcineurin) inhibitor, with an IC50 of 2-4 nM for PP2B-Aα. As a pyrethroid ester, it exhibits significant insecticidal and acaricidal properties. This compound is utilized in various research applications to study protein phosphatase signaling pathways and to explore potential therapeutic targets in bacterial infections. -
Nephrotoxin
Orellanine is a potent fungal nephrotoxin primarily known for its mechanism as a competitive inhibitor of alkaline phosphatase. This compound effectively induces apoptosis in proximal tubular cells and clear cell renal cell carcinoma (ccRCC) cell lines. Orellanine serves as a valuable tool for research focused on nephrotoxicity and the pathophysiology of ccRCC. -
Antibiotic
Fostriecin is a triene antibiotic that primarily targets topoisomerase II and inhibits protein phosphatase PP2A. It exhibits potent antibacterial activity and has been employed in research focused on mechanisms of antibiotic resistance and cancer therapy. Its unique mechanism of action makes it a valuable tool for studying cellular processes related to gene expression and cell cycle regulation. -
Calcineurin Phosphatase Inhibitor
Dibefurin is a potent inhibitor of calcineurin phosphatase, a critical regulator of calcium-dependent signaling pathways. This fungal metabolite has demonstrated significant biological activity in various cellular processes, making it a valuable tool for studying immune response and neuronal signaling. Its application extends to research focused on autoimmune diseases and neurodegenerative disorders, where calcineurin activity plays a pivotal role. -
IMPase Inhibitor
L-671776 is a non-competitive inhibitor of inositol monophosphatase (IMPase), a critical enzyme in the phosphoinositide signaling pathway. This compound, derived from the fungal strain ATCC 20928B, exhibits significant potential for modulating inositol levels and can be utilized in studies investigating mood disorders, neurodegenerative diseases, and other conditions linked to inositol metabolism. Its application in biochemical research can help elucidate the role of IMPase in cellular signaling processes. -
PTP1B Inhibitor
Deoxyfunicone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating an IC50 value of 24.3 µM through direct active site binding. This secondary fungal metabolite exhibits notable anti-inflammatory properties, making it a valuable tool for research into metabolic regulation and the treatment of inflammatory diseases. Its mechanism of action positions it as a significant compound for studies focused on diabetes and obesity-related conditions.
