Catalog No.
Product Name
Application
Product Information
Citations
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Antifungal Cyclic Dipeptide
Cyclo(L-Phe-L-Pro) is an antifungal cyclic dipeptide that selectively targets the retinoic-acid-inducible gene-I (RIG-I) pathway, thereby inhibiting IFN-β production. Isolated from cell-free culture supernatants of Pseudomonas fluorescens and Pseudomonas alcaligenes, this compound demonstrates significant free-radical scavenging ability, with an IC50 of 24 µM in the DPPH assay. It serves as a valuable reagent in studies related to antifungal mechanisms and oxidative stress response. -
Drug Derivative
UDP-rhamnose is the activated form of rhamnose that plays a crucial role in the synthesis of rhamnose-containing glycans in fungi. This nucleotide sugar acts as a key substrate for glycosyltransferases, enabling the assembly of polysaccharides involved in the fungal cell wall. UDP-rhamnose is utilized in research focused on understanding fungal pathogenesis and the development of therapeutics for fungal infections. -
Fungicide
Pyrimethanil is an anilinopyrimidine fungicide that primarily targets the biosynthesis of methionine and other amino acids in Botrytis cinerea. This broad-spectrum contact fungicide effectively controls Botrytis spp. on a variety of crops, including fruits, vegetables, and ornamental plants. Pyrimethanil is utilized in research focused on the prevention of mold infections and the management of fungal diseases in agricultural settings. -
Antibiotic Fungicide
Validamycin A acts as an antibiotic fungicide primarily targeting fungal pathogens. Isolated from Streptomyces hygroscopicus var. limoneus, it exhibits significant inhibitory effects against Aspergillus flavus, with a minimum inhibitory concentration (MIC) of 1 µg/mL. Additionally, Validamycin A demonstrates potent inhibition of trehalase in Rhizoctonia solani, with an IC50 value of 72 µM. It also functions as a reversible inhibitor of tyrosinase, exhibiting a Ki value of 5.893 mM, making it a valuable reagent for agricultural and biochemical research applications. -
Lignin Intermediate
Coniferyl alcohol is a key intermediate in lignin biosynthesis with antifungal properties. It has been shown to specifically inhibit the growth of fungi such as Verticillium longisporum, as well as impede the growth of Nicotiana benthamiana seedlings. Additionally, coniferyl alcohol demonstrates potential benefits in improving cardiac dysfunction associated with renovascular hypertension and cardiac inflammation, making it valuable for research in both plant pathology and cardiovascular studies. -
Building Block
2,5-Furandimethanol serves as a versatile building block in the enzymatic synthesis of bio-based polyesters. This compound is also a significant metabolite derived from the fungus Phellinus linteus, which has been implicated in the treatment of leukemia. Additionally, 2,5-Furandimethanol may provide insights in the study of fungal infections, making it a valuable reagent in various biological research applications. -
Antifungal Agent
D-Gluconic acid potassium is a carboxylic acid that exhibits antifungal activity through its antiseptic and chelating properties. This compound is suitable for research applications in the field of mycology and can aid in the study of fungal infections and their treatment mechanisms. Its ability to chelate metal ions further enhances its potential utility in various biochemical assays. -
β-1,3-Glucan Inhibitor
Ibrexafungerp is an orally active β-1,3-glucan synthesis inhibitor with demonstrated antifungal properties. Its mechanism targets the cell wall biosynthesis pathway of fungi, making it valuable in research on Candida and Aspergillus infections. This compound is a promising candidate for studies focused on antifungal resistance and the development of new antifungal therapies. -
Antifungal
Prochloraz is an imidazole antifungal agent that primarily functions as a dual antagonist of estrogen receptors (ER) and androgen receptors (AR), as well as an aromatase inhibitor with IC50 values of 25 μM, 4 μM, and 0.3 μM, respectively. Additionally, Prochloraz activates the aryl hydrocarbon receptor (AhR) with an EC50 of 1 μM. This compound is useful in research focused on endocrine disruption and antifungal activity, making it a valuable tool for studies in toxicology and pharmacology. -
Antifungal Agent
2-Phenylethyl isothiocyanate is a potent antifungal agent targeting fungal growth and development. It significantly inhibits spore germination and mycelial growth of Alternaria alternata, exhibiting a minimum inhibitory concentration (MIC) of 1.22 mM. The antifungal action of 2-Phenylethyl isothiocyanate involves the reduction of toxin levels and disruption of cell membrane integrity, making it a valuable compound for research into fungal pathogens and potential therapeutic applications. -
Antifungal/Antibacterial/Antiviral Agent
Cyclo(L-Leu-L-Pro) is a cyclic dipeptide that serves as a broad-spectrum antibacterial, antiviral, and antifungal agent. It is particularly effective in inhibiting aflatoxin production in Aspergillus flavus and exhibits significant antibacterial activity against multi-drug resistant bacteria, especially in its cis configuration. Additionally, Cyclo(L-Leu-L-Pro) demonstrates notable antiviral properties, specifically inhibiting the influenza A virus H3N2. This compound is valuable for research applications focused on infectious diseases and microbial resistance. -
Volatile Organic Compound
2,5-Dimethylcyclohexanol is a volatile organic compound with significant antineoplastic and antiviral properties, particularly through its inhibition of SARS-CoV-2 Mpro. Additionally, it exhibits potent antifungal activity against Pseudogymnoascus destructans, compromising cell wall and membrane integrity while disturbing energy metabolism. This compound increases reactive oxygen species (ROS), ATP, superoxide anions, and glutathione (GSH) levels, while reducing catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, 2,5-Dimethylcyclohexanol influences the expression of virulence-related ribosomal genes and disrupts MAPK signaling pathways, leading to fungal cell apoptosis. -
Antitumor Antibiotic
Peplomycin sulfate is an antitumor antibiotic that acts by inducing DNA strand breaks, thereby promoting apoptosis in cancer cells. It exhibits significant antitumor activity while displaying relatively low pulmonary toxicity. Additionally, Peplomycin sulfate has been shown to induce various skin abnormalities and can lead to pulmonary fibrosis. This compound is valuable for research applications related to cancer, pulmonary fibrosis, and other associated diseases. -
Fungicide
(Rac)-Epoxiconazole is a chiral triazole fungicide that exhibits inhibitory activity against a wide range of fungal pathogens. This compound demonstrates long-lasting fungicidal effects, making it suitable for agricultural applications where persistent protection is essential. Its persistence in soil is noteworthy, with a reported half-life exceeding 300 days, indicating prolonged efficacy in reducing fungal populations in treated areas. -
Anti-HSV-1/cancer Agent
Perillic acid is a metabolite of Perillyl alcohol and primarily acts as an anti-HSV-1 agent and cancer therapeutic. It has been shown to induce cell cycle arrest and apoptosis in lung cancer cells, highlighting its potential as an anticancer agent. Additionally, Perillic acid exhibits immunomodulatory properties, making it a valuable compound for research in virology and oncology. -
HBV Inhibitor
HBV-IN-23 is a potent inhibitor of Hepatitis B virus (HBV) DNA replication with an IC50 of 0.58 μM. This compound effectively inhibits HBV replication across both sensitive and resistant strains. Additionally, HBV-IN-23 demonstrates anti-hepatocellular carcinoma activity by inducing apoptosis in HepG2 cells, making it a valuable tool for research into HBV and related hepatic conditions. -
Parasite Inhibitor
Quinacrine acetate is a potent modulator of the cGAS-STING-TBK1 signaling pathway, exhibiting notable immune stimulatory activity. This compound has been investigated for its therapeutic potential in enhancing anti-tumor immunity and improving the efficacy of cancer immunotherapies by addressing the immunogenicity challenges faced by various tumors. Quinacrine acetate also represents a promising approach to mitigate the limitations associated with immune checkpoint inhibitors in cancer treatment. -
Anti-tumour Antibiotic
Boanmycin is an anti-tumor antibiotic that exerts its biological activity by inducing cellular senescence and apoptosis in cancer cells. This compound is primarily utilized in research to explore mechanisms of tumor suppression and to assess its potential therapeutic applications in oncology. Its ability to promote programmed cell death makes it a valuable tool for studying cancer biology and developing novel treatment strategies. -
Antifungal Agent
Sertaconazole is a broad-spectrum topical antifungal agent that primarily targets fungal cell membranes. It exhibits significant anti-inflammatory activity by activating the p38-COX-2-PGE2 signaling pathway. Additionally, Sertaconazole functions as a microtubule inhibitor, demonstrating antiproliferative effects, and inducing apoptosis and autophagy. Its ability to inhibit cellular migration makes it valuable in various research applications related to fungal infections and inflammatory conditions. -
Antibiotic
4-Epianhydrotetracycline hydrochloride is an antibiotic that serves as a significant intermediate in tetracycline synthesis. It demonstrates cytotoxic effects and induces apoptosis in zebrafish embryos, highlighting its potential for developmental toxicology studies. Furthermore, it exhibits antimicrobial activity against Shewanella, Escherichia coli, and Pseudomonas aeruginosa, with minimum inhibitory concentrations of 2 mg/L, 1 mg/L, and 64 mg/L, respectively, indicating its utility in microbial resistance research. -
Bacterial Metabolite Xie
Collismycin A is a bacterial metabolite targeting multiple cellular pathways, originally isolated from Streptomyces. Exhibiting antibacterial, antiproliferative, and neuroprotective properties, it demonstrates activity against various bacteria and fungi (MICs ranging from 6.25 to 100 μg/mL). Notably, Collismycin A inhibits the proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells, with IC50 values of 0.3, 0.6, and 0.3 μM, respectively, while demonstrating minimal impact on MDA-MB-231 breast cancer cells (IC50 > 100 μM). Furthermore, it forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, where the presence of iron ions can attenuate its antiproliferative effects in HeLa cells, and it exhibits protective effects against neuronal cell death in zebrafish larvae models. -
Antibacterial Agent/eEF2K Inhibitor
Cefatrizine is a broad-spectrum cephalosporin antibiotic that primarily targets bacterial infections while also acting as an eEF2K inhibitor. This compound exhibits anti-proliferative activity in human breast cancer cells, inducing endoplasmic reticulum stress and subsequent cell death. Cefatrizine is a valuable reagent for research applications in understanding mechanisms of cancer therapy and exploring antibacterial efficacy. -
Ras Inhibitor
(-)-Rasfonin is a natural fungal secondary metabolite that acts as an inhibitor of small G protein Ras. It exhibits significant biological activities, including the induction of apoptosis, necrosis, and autophagy in ACHN cells, a renal carcinoma cell line. This compound is instrumental for research focused on cellular death pathways and therapeutic strategies targeting Ras-mediated signaling in cancer. -
Antibiotic
Deoxynybomycin is an antibiotic that acts as an inhibitor of DNA gyrase and Topoisomerase I. It demonstrates significant antibacterial activity against Staphylococcus aureus and induces the expression of p21/WAF1. Additionally, Deoxynybomycin exhibits cytotoxic effects and promotes apoptosis in various cancer cell lines, including Saos-2, TMK-1, and THP-1, making it a valuable tool for research in antimicrobial and cancer biology. -
Anti-tumour Antibiotic
Boanmycin hydrochloride is an anti-tumor antibiotic that exhibits significant cytotoxic effects against various cancer cell lines. It functions by inducing cellular senescence and apoptosis, making it a valuable tool for studying mechanisms of tumor progression and resistance. This compound is useful in cancer research and can aid in the development of therapeutic strategies targeting malignant cells. -
Antibiotic
Undecylprodigiosin hydrochloride is an antibiotic derived from the prodiginine class of compounds. It exhibits potent antimicrobial activity and selectively induces apoptosis in human breast carcinoma cells through a p53-independent mechanism. Additionally, this compound demonstrates immunosuppressive and anticancer properties, making it a valuable tool for research in cancer therapy and microbial studies. -
Antitumor Antibiotic
Antibiotic DC 81 is a potent antitumor antibiotic derived from Streptomyces species, classified as a pyrrolo[2,1-c][1,4]benzodiazepine (PBD). It functions primarily as an inhibitor of nucleic acid synthesis by recognizing and binding to specific DNA sequences, resulting in the formation of a labile covalent adduct. This ability to interact with DNA makes Antibiotic DC 81 valuable for research in cancer biology and the development of novel therapeutic agents targeting DNA. -
Antibacterial Agent
Chlorhexidine acetate hydrate is a cationic antimicrobial agent that targets microbial cell membranes. By non-specifically binding to cell membrane phospholipids, it disrupts membrane integrity, leading to leakage of cellular contents and bacterial cell death. This compound exhibits broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Its ability to interfere with membrane permeability and induce protein precipitation makes it valuable for research applications focused on microbial growth inhibition and mechanisms of cell death. -
Azoxystrobin Enantiomer
(Z)-Azoxystrobin is an enantiomer of Azoxystrobin, a broad-spectrum β-methoxyacrylate fungicide. It functions by inhibiting mitochondrial respiration through binding to the Qo site of the cytochrome bc1 complex, thereby disrupting electron transfer. The compound is known to induce the production of reactive oxygen species (ROS), ultimately leading to cell apoptosis. It is primarily used in research applications involving fungal inhibition and the study of mitochondrial function. -
Antibiotic
FSL-1 is a bacterial-derived agonist of toll-like receptor 2/6 (TLR2/6). It exhibits immunostimulatory activity that enhances resistance against experimental Herpes Simplex Virus Type 2 (HSV-2) infection. This compound is valuable for research applications focused on innate immunity and the development of therapeutic strategies for viral infections. -
β-lactamase Inhibitor
RDR 02308 is a β-lactamase inhibitor that targets the TLR4-MyD88 signaling pathway. This compound effectively inhibits the activity of full-length β-lactamase, providing a valuable tool for studies related to antibiotic resistance. Its mechanism of action makes it suitable for research applications focused on bacterial infections and the development of novel therapeutic strategies. -
Anti-HIV Agent
Moronic Acid is a triterpenoid compound that serves as an orally available anti-HIV agent, exhibiting significant anti-inflammatory properties. It demonstrates the ability to inhibit viral replication, with an EC50 value of less than 1 μg/mL. Moronic Acid can be isolated from Brazilian propolis and is utilized in research focused on HIV treatment and related viral studies. -
Antitumor/ Antibacterial Agent
Epanorin is a secondary metabolite derived from the Acarospora lichenic species, primarily targeting tumor cells and bacterial pathogens. It exhibits potent antitumor activity by inhibiting cancer cell proliferation, reducing reactive oxygen species (ROS) production, and inducing cell cycle arrest in the G0/G1 phase. Additionally, Epanorin demonstrates antibacterial properties, making it valuable for research applications focused on cancer treatment and bacterial infections, including studies on breast cancer and Streptococcus pneumoniae infections. -
Antibacterial Agent
Deoxymikanolide is an orally active antibacterial agent that primarily targets catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. It enhances glycan and phosphorus metabolism, increases electrical conductivity, and elevates levels of intrabacterial reactive oxygen species (ROS) and malondialdehyde (MDA). These actions result in cell shrinkage, cytoplasmic damage, and disruption in Ralstonia solanacearum. Additionally, Deoxymikanolide demonstrates efficacy in inhibiting acetic acid-induced writhing in mice, making it a valuable tool for research on bacterial wilt. -
Antibacterial Peptide
KSL-W is a multifunctional antibacterial peptide primarily targeting immune regulation. It exhibits significant chemotactic effects on neutrophils and promotes F-actin polymerization through the Gαi protein signaling pathway. Additionally, KSL-W effectively inhibits the production of reactive oxygen species (ROS) in neutrophils. This peptide is valuable for research focused on infection control and the regulation of inflammatory processes. -
Antileishmanial Agent
PT4 is an antileishmanial agent specifically effective against cutaneous leishmaniasis. It exhibits significant activity against both Leishmania species, with IC50 values of 125.18 µM for L. amazonensis and 233.18 µM for L. braziliensis. PT4 induces a reduction in mitochondrial membrane potential and elevates reactive oxygen species production, resulting in parasite lethality. Additionally, PT4 demonstrates potent in vivo anti-inflammatory properties, making it a valuable tool for research in leishmaniasis and related inflammatory conditions. -
Antibacterial Agent
Aloe vera, a natural herbal extract, exhibits significant antibacterial activity. It is recognized for its anti-inflammatory and antioxidant properties, making it a valuable candidate for research applications in areas such as tumor biology, diabetes, bone disorders, and cardiovascular health. Its diverse biological effects support its potential use as a therapeutic agent in various biomedical studies. -
Antibacterial Agent
ROS inducer 9 is an antibacterial agent that functions by inhibiting glutathione (GSH) activity and elevating reactive oxygen species (ROS) levels. With a minimum inhibitory concentration (MIC) of 0.25 μg/mL against E. coli, it demonstrates potent antibacterial properties. Additionally, ROS inducer 9 exhibits low toxicity to erythrocytes and RAW 264.7 cells, making it suitable for various biological research applications in exploring oxidative stress responses in bacterial infections. -
Anti-bacterial Agent
Anti-MRSA agent 36 is an antibacterial compound that exhibits potent activity against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 1 μg/mL. This agent specifically targets phosphatidylglycerol (PG) in bacterial membranes, leading to compromised membrane integrity, DNA leakage, and increased reactive oxygen species (ROS) production. Characterized by low cytotoxicity and minimal hemolytic effect, Anti-MRSA agent 36 also demonstrates a reduced propensity for inducing drug resistance and good plasma stability, making it suitable for research involving skin abscess and systemic infection models. -
Antibacterial Agent
Antibacterial Agent 308 is an antibacterial compound that selectively targets bacterial membranes by binding to phosphatidylethanolamine, leading to membrane polarization disruption and increased intracellular reactive oxygen species (ROS) levels. This agent exhibits significant anti-biofilm activity against Staphylococcus aureus and demonstrates potent anti-methicillin-resistant Staphylococcus aureus (MRSA) efficacy. Its unique mechanism makes it a valuable tool for research focused on combating bacterial infections and biofilm-related challenges. -
Superoxide Anion Inhibitor
Tanzawaic acid B is a potent inhibitor of superoxide anion production, derived from the fungal source Penicillium citrinum. This compound has been demonstrated to mitigate oxidative stress by targeting superoxide radicals, making it valuable for research in oxidative damage and related pathologies. Its biological activity provides a useful tool for studying the effects of reactive oxygen species in various cellular models. -
Antileishmanial Agent
Antileishmanial agent-35 is a potent antileishmanial compound that targets Leishmania amazonensis, exhibiting an IC50 of 0.29 μM against promastigotes. This compound disrupts mitochondrial function by lowering the mitochondrial membrane potential and ATP levels, while also enhancing reactive oxygen species (ROS) production due to interference with the electron transport chain. Antileishmanial agent-35 is suitable for research focused on cutaneous leishmaniasis and its underlying mechanisms of action. -
Antibiotic
TAN-420E (Dihydroherbimycin A) is an antibiotic derived from the fermentation of Streptomyces hygroscopicus. This compound demonstrates significant cytotoxicity against P-388 and KB cancer cell lines, highlighting its potential as an anti-cancer agent. In addition, TAN-420E effectively scavenges DPPH free radicals, with an IC50 value of 1.3 μM, indicating its potential antioxidant properties. Research applications include investigations into its antimicrobial and anticancer effects. -
Glycylcycline Antibiotic
Tigecycline hydrate is a glycylcycline antibiotic characterized by its broad-spectrum antibacterial activity. It exhibits significant inhibitory effects against various bacterial strains, with a mean inhibitory concentration (MIC) of approximately 125 ng/mL for E. coli (MG1655 strain). In addition, it displays MIC50 and MIC90 values of 1 mg/L and 2 mg/L, respectively, for Acinetobacter baumannii. This compound is valuable for research applications related to antibiotic efficacy and resistance studies. -
Antibacterial Agent
3,4-Dimethoxychalcone acts as an antibacterial agent by inducing deacetylation of cytoplasmic proteins, thereby promoting autophagy flux. This compound is relevant for research applications focused on disease mechanisms related to cardiac and cancer biology, offering potential pathways for therapeutic intervention. Researchers may explore its effects on cellular processes and its role as a caloric restriction mimetic in various experimental models. -
HIV-1 RT Inhibitor
Apricitabine is a selective inhibitor of HIV-1 reverse transcriptase (RT) with a Ki value of 0.08 μM. It also exerts inhibitory effects on DNA polymerases α, β, and γ, with corresponding Ki values of 300 μM, 12 μM, and 112.25 μM. Demonstrating significant antiretroviral efficacy and favorable tolerability, Apricitabine shows a reduced potential for resistance development in patients with antiretroviral-naive HIV infection. This compound is applicable for research in the mechanisms of HIV-1 replication and antiviral drug development. -
Antibacterial Agent
BWC0977 is an antibacterial agent that primarily targets bacterial DNA replication by inhibiting DNA gyrase and topoisomerase IV. This compound demonstrates potent activity with a minimum inhibitory concentration (MIC90) ranging from 0.03 to 2 µg/mL against multi-drug resistant Gram-negative bacteria. BWC0977 is suitable for research applications involving the study of bacterial resistance mechanisms and the development of new antimicrobial strategies. -
Antibacterial Agent
BWC0977 formic is an antibacterial agent that targets bacterial DNA replication by inhibiting DNA gyrase and topoisomerase IV. It demonstrates significant antibacterial activity, with a minimum inhibitory concentration (MIC90) ranging from 0.03 to 2 µg/mL against multi-drug resistant Gram-negative bacteria. This compound is valuable for research applications focused on combating antibiotic resistance and exploring therapeutic strategies for resistant infections. -
Antibiotic
Rifaquizinone is a hybrid antibiotic that combines the mechanisms of Rifamycin and Quinolone. It effectively inhibits wild-type Staphylococcus aureus RNA polymerase, exhibiting an IC50 value of 34 nM. Rifaquizinone demonstrates potent antibacterial activity against S. aureus infections, with minimum inhibitory concentrations (MICs) ranging from 0.008 to 0.5 μg/mL across 300 clinical isolates of staphylococci and streptococci, making it a valuable tool for antibiotic research and investigation into resistance mechanisms. -
Antibiotic
Erythromycin (aspartate) is a macrolide antibiotic that exerts its effects by binding to the 50S ribosomal subunit of bacteria, inhibiting RNA-dependent protein synthesis through the blockage of transpeptidation and translocation reactions. This compound demonstrates a broad spectrum of antimicrobial activity, making it an important tool in microbiological research. Additionally, erythromycin aspartate has shown potential antitumor and neuroprotective properties, expanding its applications in various fields of biomedical research.
