Catalog No.
Product Name
Application
Product Information
Citations
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CCR1 Antagonist
CCR1 antagonist 12 is a selective antagonist of the CCR1 receptor, exhibiting an IC50 of 3 nM for human CCR1. This compound effectively inhibits CCL3-induced transwell chemotaxis, with an IC50 of 0.009 µM, making it a valuable tool for studying chemokine-mediated signaling pathways. Additionally, CCR1 antagonist 12 demonstrates favorable pharmacokinetic properties in rat models, supporting its potential use in preclinical research. -
CCR3 Antagonist
Maceneolignan H is a selective CCR3 antagonist, with an EC50 value of 1.4 μM. Isolated from the arils of Myristica fragrans, this neolignane compound demonstrates significant potential in the study of allergic diseases. Its ability to inhibit CCR3 suggests applications in researching therapeutic strategies for conditions mediated by this receptor. -
Ligand for CCR2
CCR2 ligand-1 is a potent ligand for the chemokine receptor CCR2, playing a crucial role in mediating inflammatory responses. This compound is valuable for studying CCR2 signaling pathways and its implications in diseases such as cancer and rheumatoid arthritis. Additionally, CCR2 ligand-1 can be utilized in the synthesis of LUF7996 when conjugated with Linker PIN1 degrader-3 and E3 ligase ligand Thalidomide 4-fluoride, facilitating research in targeted protein degradation. -
CCR3 Antagonist
BMS-639623 is a highly potent and orally bioavailable antagonist of the chemokine receptor CCR3, exhibiting an IC50 value of 0.3 nM. This compound demonstrates exceptional inhibitory activity against eosinophil chemotaxis, with an IC50 of 38 pM. BMS-639623 is primarily utilized in research focused on asthma and related inflammatory conditions. -
CCR3 Antagonist
CCR3 Antagonist 2 is a selective antagonist of the CCR3 receptor, a chemokine receptor involved in mediating inflammatory responses. This compound is particularly useful for research applications related to inflammatory and allergic conditions, including obstructive airways diseases. By interfering with CCR3 signaling, it allows for the exploration of therapeutic strategies aimed at modulating immune responses associated with these pathologies. -
CCR Antagonist
RAP-103 is a potent orally active CCR antagonist that targets the CCR pathway to provide synaptic protection. It effectively inhibits and reverses cytoskeletal alterations induced by PrPC/NOX signaling. RAP-103 is particularly relevant for research applications focused on Alzheimer's disease, offering insights into neuroprotective mechanisms and potential therapeutic strategies. -
CCR1 Inhibitor
BX-513 is a potent and selective antagonist of the CCR1 receptor. It effectively inhibits the binding of radiolabeled MIP-1α and RANTES to CCR1, with inhibition constants (Ki) of 40 nM and 60 nM, respectively. BX-513 demonstrates the ability to suppress MIP-1α-induced extracellular acidification, as well as MIP-1α- and RANTES-induced intracellular calcium mobilization and peripheral blood mononuclear cell migration. This compound is applicable in research focusing on autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. -
CCR2/CCR5 Antagonist
PF-4178903 is a potent dual antagonist of the chemokine receptors CCR2 and CCR5, exhibiting IC50 values of 3 nM and 5.3 nM, respectively. This orally active compound is valuable in the study of chronic inflammatory conditions and autoimmune diseases, providing insights into the modulation of immune responses. Its dual targeting capability makes PF-4178903 a significant tool for exploring therapeutic avenues in related research applications. -
CCR8 Agonist
LMD-584 is a selective agonist of CCR8, a chemokine receptor involved in immune responses and inflammation. This compound demonstrates significant biological activity in modulating CCR8 signaling pathways, making it a valuable tool for research applications focused on immune cell trafficking and related pathologies. LMD-584 may aid in understanding the role of CCR8 in various diseases, including cancer and autoimmune disorders. -
CCR5 Modulator
CCR5 modulator-1 is a selective modulator of the CCR5 chemokine receptor. This compound plays a significant role in the regulation of inflammatory processes and can be applied in research aimed at understanding various inflammatory diseases. Its use may provide insights into therapeutic strategies targeting CCR5-related pathways. -
Anti-CCR2 Antibody
Minokitug is a humanized monoclonal antibody that specifically targets the CCR2 protein. It exhibits significant biological activity by inhibiting CCR2-mediated signaling pathways, making it a valuable tool for studying inflammatory processes. This reagent is particularly relevant in research focused on refractory or relapsed ulcerative colitis, aiding in the understanding of the disease's pathophysiology and potential therapeutic interventions. -
CCR2 PROTAC Degrader
LUF7996 is a potent CCR2 PROTAC degrader that selectively targets and degrades CCR2 with a DC50 value of 2.6 μM. This compound effectively engages with the E3 ligase cereblon, promoting sustained and concentration-dependent degradation of CCR2 via the lysosomal pathway. LUF7996 is particularly valuable for research applications involving the inhibition of monocyte migration in vitro, facilitating studies in inflammation and immune response modulation. -
CCR1 Antagonist
cis-J-113863 is a competitive antagonist of chemokine receptor 1 (CCR1) that exhibits potent inhibitory effects, with IC50 values of 0.9 nM for human CCR1 and 5.8 nM for mouse CCR1. This compound is valuable for research in inflammation, immune response, and related therapeutic areas, facilitating the investigation of CCR1's role in various biological processes and disease models. -
CCR1 Antagonist
CCR1 antagonist 13 is a selective antagonist of the CCR1 chemokine receptor. This small molecule inhibitor effectively disrupts CCR1 signaling, making it a valuable tool for investigating the roles of CCR1 in inflammatory responses and immune cell migration. Its applications extend to research on autoimmune diseases, chronic inflammatory conditions, and the modulation of chemokine-mediated pathways. -
CCR2 Inhibitor-DOTA Conjugate
DOTA-ECL1i is a CCR2 inhibitor conjugated with DOTA, designed for use in positron emission tomography (PET) imaging. When radiolabeled with 68Ga, DOTA-ECL1i provides a specific PET tracer that targets CCR2 expression in various pathological conditions. This compound is applicable in research focused on pulmonary fibrosis, cardiac injury, abdominal aortic aneurysm inflammation, atherosclerosis, and cancers of the head, neck, and pancreas. -
CCR6/CXCR2 Antagonist
SQA1 is a squaramide derivative that functions as a CCR6 and CXCR2 antagonist, displaying a dissociation constant (Kd) of 250 nM. It effectively occupies the intracellular pocket, overlapping with the G protein binding site, which helps stabilize the closed conformation of the receptor. This compound is useful in research applications targeting chemokine receptor signaling pathways and their roles in inflammatory responses and immune cell trafficking. -
CCR2 Antagonist
CCR2 Antagonist 6 is a potent CCR2 antagonist with a Ki value of 0.215 μM for CCR2 and 0.174 μM for human CCR2B. This compound exhibits significant biological activity by inhibiting the CCR2 receptor, making it a valuable tool for studying inflammatory processes and autoimmune diseases. Its specificity and efficacy contribute to the understanding of CCR2-related pathways in various pathophysiological conditions. -
CCR5 Antagonist
CCR5 antagonist 5 is an effective CCR5 antagonist that targets the CCR5 receptor, playing a critical role in modulating immune response and inflammation. This compound is particularly valuable for research applications focused on HIV infection and other viral pathogens, offering insights into therapeutic strategies for immunological disorders and viral disease management. -
CCR9 Modulator
CCR9 modulator-1 is a selective modulator of the chemokine receptor CCR9, primarily involved in T-cell trafficking and immune response regulation. This compound demonstrates significant potential in influencing CCR9-mediated immune pathways, making it a valuable tool for the study of inflammatory diseases such as Crohn's disease and other gastrointestinal disorders. Researchers can utilize CCR9 modulator-1 to explore therapeutic strategies targeting CCR9 in various immunological contexts. -
CCR1/CCR3 Antagonist
trans-J-113863 is a potent antagonist of the CCR1 and CCR3 chemokine receptors. It effectively inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, exhibiting IC50 values of 9.57 nM and 93.8 nM, respectively. This compound serves as a valuable tool for research focused on inflammation and immune responses, offering insights into the roles of these receptors in various biological contexts. -
CCR8 Antagonist
CCR8 antagonist 3 is a selective antagonist of the CCR8 receptor, exhibiting an IC50 value of 0.062 µM. This compound demonstrates stability in human microsomes, making it suitable for various in vitro studies. Its potential applications include exploring mechanisms of immune response modulation and investigating therapeutic strategies for inflammatory diseases and cancer. -
CCR5/CXCR3 Inhibitor
CCR5/CXCR3-IN-1 is a potent inhibitor of the chemokine receptors CXCR3 and CCR5. This compound effectively suppresses the chemotaxis of transformed cells expressing CCR5 and CXCR3, while exhibiting no inhibitory effect on CXCR4-expressing transfected cells. CCR5/CXCR3-IN-1 is valuable for research into chronic arthritic rheumatism and other conditions where modulation of these receptors is crucial. -
CCR1 Antagonist
CP-865569 is a potent CCR1 antagonist, specifically designed to inhibit the activity of the CCR1 chemokine receptor. This compound demonstrates potential therapeutic effects in the modulation of inflammatory responses, making it valuable for research into inflammatory and autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. Its ability to selectively target CCR1 makes CP-865569 an important tool for investigating the roles of chemokines in disease pathology and therapeutic intervention. -
CCR1 Antagonist
BMS-457 is a potent and selective antagonist of the chemokine receptor CCR1. This compound demonstrates significant biological activity in modulating inflammatory pathways and is primarily utilized in research applications related to rheumatoid arthritis. Its ability to inhibit CCR1 makes it a valuable tool for studying the role of chemokines in autoimmune disorders. -
CCR5 Antagonist
SCH 350581 is a CCR5 antagonist that effectively inhibits HIV-1 replication. By obstructing viral entry into host cells and preventing the binding of the gp120 protein to primary lymphocytes, SCH 350581 plays a critical role in studying HIV-1 pathogenesis and potential therapeutic interventions. This compound is valuable for research applications focused on antiviral drug development and the mechanisms of HIV entry. -
CCR8 Antagonist
AZ760 is a potent antagonist of the CCR8 receptor, which plays a significant role in immune response modulation. This compound demonstrates excellent potency and favorable lipophilicity, resulting in a high free fraction in blood. However, it is important to note that AZ760 exhibits unacceptable inhibition of the hERG potassium channel, which may have implications for cardiovascular safety in therapeutic applications. -
Asperlicin
Asperlicin D is an metabolite derived from the Aspergillus alliaceus strain (ATCC 20656), primarily involved in the regulation of fungal biosynthesis. It exhibits antifungal and antibacterial activities through inhibition of various biological pathways. Due to its potential therapeutic properties, Asperlicin D is of interest in studies related to natural product chemistry and antimicrobial drug development. -
CXCR2/CCR7 Antagonist
CCR7 antagonist 1 is a potent dual antagonist of CXCR2 and CCR7, exhibiting an IC50 of 11.02 μM for CXCR2 and 0.43 μM for CCR7. This compound demonstrates significant inhibition of chemokine receptor signaling, making it valuable for studying inflammatory responses and immune system modulation. Its application spans various fields, including cancer research and autoimmune disease studies, where targeting these receptors can provide insights into disease mechanisms and potential therapeutic strategies. -
CCR7 Antagonist
SLW131 is a potent CCR7 antagonist, demonstrating a high affinity with a Ki value of 9.85 nM. This compound effectively inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM, as well as β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also disrupts CCL19-induced morphological alterations in primary bone marrow-derived dendritic cells and impedes CCR7-mediated migration in mouse CD4+ T cells, making it a valuable tool for research in immune response and cell signaling pathways. -
CCR6 Antagonist
IDOR-1117-2520 is a potent and selective reversible antagonist targeting CCR6. It effectively inhibits CCL20-mediated calcium influx with an IC50 of 63 nM and blocks β-arrestin recruitment to human CCR6, showing an IC50 of 30 nM in recombinant cell models. As a substrate of P-glycoprotein/MDR1, IDOR-1117-2520 is a valuable tool for investigating autoimmune diseases and skin inflammation in research settings. -
Bacterial Metabolite
Palmitoyl serinol is a bacterial metabolite analog of the endocannabinoid N-palmitoyl ethanolamine (PEA). It exhibits enhanced activity in improving the epidermal permeability barrier, demonstrating efficacy in both normal and inflamed skin conditions. Its unique properties make it a valuable tool for research into skin barrier function and inflammation-related studies. -
HIV-I Integrase Inhibitor
Bis-T-23 is a potent inhibitor of HIV-1 integrase, acting through a tyrphostin derivative mechanism. This compound has been shown to promote actin-dependent dynamin oligomerization, highlighting its role in cellular processes related to viral replication. Bis-T-23 is valuable for research focused on HIV and chronic kidney diseases (CKD), providing insights into the intersection of viral infection and renal pathophysiology. -
Myosin I Inhibitor
ZJS178 is a selective inhibitor of myosin I, exhibiting significant antifungal activity against Fusarium graminearum. This compound effectively reduces the synthesis of the mycotoxin deoxynivalenol (DON) and is valuable for research on plant diseases, particularly wheat scab. ZJS178 serves as a potent tool for studies aimed at understanding myosin I functions in fungal pathogenesis and developing strategies for disease management in crops. -
Active Compound
Phenylpyruvic acid is a precursor to phenyllactic acid and serves as an active compound with antifungal properties. This reagent enhances the antifungal activity of various lactic acid bacterial strains when incorporated into defined growth media. Phenylpyruvic acid exhibits significant inhibitory effects against fungal contaminants such as Aspergillus niger and Penicillium roqueforti. Additionally, it influences the enzymatic activity of the pentose phosphate pathway in rat brain homogenates, notably reducing glucose-6-phosphate dehydrogenase activity. This compound is valuable for research applications in microbiology and metabolic studies. -
Telomerase
Diazaphilonic acid is a compound that targets telomerase, functioning by inhibiting its activity. Derived from the fungal strain Talaramuces flavus PF1195, it demonstrates significant potential in disrupting DNA amplification processes. This makes it a valuable reagent for research applications focused on telomere biology and cancer studies. -
Antitumor Antibiotic
Saintopin is an antitumor antibiotic that selectively inhibits DNA topoisomerases I and II, key enzymes involved in DNA replication and transcription. By inducing DNA cleavage, Saintopin disrupts the integrity of the genetic material, leading to apoptosis in cancer cells. This compound is utilized in research focused on cancer biology, particularly in studies involving mechanisms of chemotherapy resistance and DNA repair processes. -
HBV Inhibitor, EBV Inhibitor
FMAU is a nucleoside analog that primarily inhibits the replication of hepatitis B virus (HBV) and Epstein-Barr virus (EBV). Once phosphorylated by human thymidine kinase, FMAU is incorporated into DNA, serving as a valuable marker for cell proliferation. Its research applications extend to studies on herpes simplex virus infection and various cancer types. -
Mitotic kinesin Inhibitor
Mitotic kinesin-IN-1 hydrochloride is a potent inhibitor of mitotic kinesin, specifically designed to disrupt the process of mitosis. This compound effectively impairs cell proliferation and has applications in cancer research, as well as investigations into cardiac hypertrophy, immune and inflammatory disorders, and fungal infections. Its ability to hinder mitotic activity makes it a valuable tool for studying various cellular processes and pathways related to these conditions. -
Anti-HSV Agent
Arabinosylhypoxanthine is a purine nucleoside analog that selectively inhibits viral DNA synthesis. It demonstrates significant anti-herpes simplex virus (HSV) activity, making it a valuable tool for research on herpes simplex virus infections. This compound can be utilized to investigate mechanisms of antiviral action and to develop therapeutic strategies against HSV. -
Fungicidal Agent
N,N-Bis(3-aminopropyl)dodecylamine serves as a potent fungicidal agent targeting Aspergillus niger. It exerts its antifungal activity by inducing oxidative stress and modulating the activity of various antioxidant and mitochondrial enzymes in a concentration- and time-dependent manner. Additionally, this compound disrupts fungal organelles and alters mitochondrial morphology, leading to impaired mitochondrial functions. N,N-Bis(3-aminopropyl)dodecylamine is valuable for research into fungicidal mechanisms and the role of oxidative stress in Aspergillus niger. -
Antibacterial Agent
Octyl decyldimethyl ammonium chloride is a quaternary ammonium compound functioning as an antibacterial agent. This reagent disrupts microbial cell membranes, resulting in cytotoxic effects. Additionally, it has been observed to increase the secretion of pro-inflammatory cytokine IL-1α, indicating potential immunological implications. Its application may be relevant in studying antibacterial mechanisms and evaluating skin irritation effects in research settings. -
NF-κB Inhibitor, GPx Inhibitor, HIV Replication Inhibitor
α-MSH (11-13) acetate is a selective melanocortin-1 receptor ligand that functions as an inhibitor of NF-κB, GPx activity, and HIV replication. It induces an acute elevation of intracellular calcium levels under certain costimulation or pathway inhibition conditions. This compound effectively suppresses TNF-α-induced NF-κB activation, inhibits colony formation of Staphylococcus aureus and Candida albicans, and demonstrates potential in the study of infections related to these pathogens, as well as in traumatic brain injury, corneal epithelial wounds, and inflammatory bowel disease research. -
Melanin Biosynthesis Inhibitor
Scytalol A is a selective inhibitor of dihydroxynaphthalene melanin biosynthesis in Lachnellula sp. A32-89, effectively disrupting melanin production without affecting the growth of the organism. This compound is valuable for research investigating melanin biosynthesis pathways and can be utilized in studies focused on fungal pigmentation and its applications in various biotechnological fields. -
Griseofulvin Metabolite
6-O-Demethyl griseofulvin is a significant metabolite of Griseofulvin, primarily acting on fungal cell division by inhibiting microtubule formation. This compound demonstrates antifungal activity, making it valuable in studying the efficacy of antifungal treatments and the metabolic pathways involving Griseofulvin. Its applications extend to research focused on dermatophyte infections and fungal resistance mechanisms. -
Metabolite
BTS44596 (Prochloraz-desimidazole-formylamino) is a key metabolite of the antifungal agent Prochloraz, primarily targeting regulatory monitoring applications. This compound serves as a critical target analyte for assessing Prochloraz residue limits in fruits and vegetables. Additionally, it facilitates simultaneous detection using LC-MS/MS methodology, making it an essential tool for food safety and environmental studies. -
DGK Inhibitor
Cochlioquinone A is a potent diacylglycerol kinase (DGK) inhibitor, exhibiting ATP-competitive properties with a Ki value of 3.1 μM. Isolated from the fungal species Drechslera sacchari, Cochlioquinone A serves as a valuable tool for studying DGK's role in cellular signaling pathways. Its inhibitory effects on DGK activity make it pertinent for research in lipid signaling and related biological processes. -
Aflatoxin B1 Metabolite
Aflatoxicol is a primary metabolite of aflatoxin B1, generated by the fungal species Rhizopus. This compound exhibits mutagenic and carcinogenic properties, making it a critical subject of study in toxicology and cancer research. Aflatoxicol serves as an important reagent for analyzing the metabolic pathways and biological effects of aflatoxin exposure. Its use can aid in evaluating the risks associated with mycotoxin contamination in food and agricultural products. -
Active Metabolite
Oseltamivir acid hydrochloride is the active metabolite of the antiviral agent Oseltamivir. This compound primarily functions as a neuraminidase inhibitor, effectively limiting the spread of influenza virus within the host. It is commonly utilized in pharmaceutical research for the assessment of antiviral efficacy and toxicity ratio analysis. -
Emodin Metabolite
2-Hydroxyemodin, an active metabolite of emodin, primarily targets hepatic microsomes. This anthraquinone, derived from fungal metabolites and found in rhubarb, exhibits mutagenic activity in Salmonella typhimurium TA1537 without the need for an activation system. It is utilized in research to investigate metabolic pathways and genetic stability. -
ACAT Inhibitor
Phenylpyropene A is a potent inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), exhibiting an IC50 of 0.8 μM. This fungal metabolite has shown significant biological activity in modulating cholesterol esterification. Its application is particularly relevant in research focused on cholesterol metabolism and related disorders.
