Others

N6022 is a potent, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with an IC50 of 8 nM and a Ki of 2.5 nM.

Benzophenonetetracarboxylic acid (3,3',4,4'-Benzophenonetetracarboxylic acid) is particularly useful in the preparation of high performance polyimides and also useful as curing agents for epoxy resins.

Exo1 is a chemical inhibitor of the exocytic pathway.

Arbidol is a Russian-made potent broad-spectrum antiviral with demonstrated activity against a number of enveloped and non-enveloped viruses.

Lodenosine is a failed experimental agent for the treatment of HIV

Trimipramine (Surmontil, Rhotrimine, Stangyl) is a tricyclic antidepressant (TCA). It has antidepressant, anxiolytic, antipsychotic, sedative, and analgesic effects

Panipenem is a carbapenem antibiotic used in combination with betamipron

Triphendiol (NV-196) is a synthetic isoflavene. Triphendiol (NV-196) is another investigational drug in the Marshall Edwards, Inc., oncology drug pipeline. Triphendiol is broadly cytostatic and cytotoxic against most forms of human cancer cells in vitro, and has been shown to cause cell cycle arrest (or stop cells increasing in number) and to induce apoptosis (or initiate programmed cell death) in various cancer cell lines.

ME-143 is a derivative of triphendiol and is a highly potent, pan acting anti-cancer.

Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity.

SNT-207707 is an oral MC4-Receptor Antagonist

Atrimustine is a conjugate of chlorambucil and β-estradiol benzoate with the antitumor activity.

CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431.

TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane.

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.

Eslicarbazepine acetate is an antiepileptic drug.

Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ?300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).

TP808 is a useful intermediate for the synthesis of diverse tetracycline antibiotics.

NVP-231 is a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK.

Quinacrine 2HCl is a histamine N-methyltransferase inhibitor

Apramycin Sulfate is a broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius

Fidaxomicin is the major analogue of a family of macrocyclic lactones isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.

Pyrroloquinoline quinone is a cofactor of microbial quinoprotein enzyme, and imidazopyrroline. A redox/cofactor found in a a class of enzymes called quinoproteins.

TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13??3 nM.

Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol.

SP-420 is an orally active small molecule that selectively binds iron and removes it from the body. In animal studies, SP-420 has shown excellent tissue penetration, highly efficient iron binding and a promising safety profile.

Deferitrin (GT-56-252) is the first drug in a class of desferrithiocin-derived hexadentate iron chelators.

Gastrofensin AN 5 free base, a 4-phenyl-tetrahydroisoquinoline derivative, is an antiulcer agent.

BAY 57-1293 is a potent helicase primase inhibitor. BAY 57-1293 inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex.

Laxogenin is a new steroidal sapogenin isolated from Smilax sieboldi Miq.

Enecadin is a neuroprotective agent extracted from patent US 8623823 B2.

Oleanolic acid hemiphthalate disodium salt is an anti-inflammatory agent.

Harmane (harman) is a heterocyclic amine found in a variety of foods including coffee, sauces, and cooked meat. It is also present in tobacco smoke.

Nafocare B1 is a synthetic immune biological response modifier.

MK-6240 is a positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs.

T807 a novel tau positron emission tomography (PET) tracer.

TN1 is a potent fetal hemoglobin (HbF) inducer.

Dansyl glutathione is a trapping agent for the quantitative estimation and identification of reactive metabolites.

ATB107 is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 μM.

RCM-1 is a FOXM1 inhibitor.

ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.

Methotrexate impurity 4 is a known impurity associated with Methotrexate, primarily classified as a drug impurity. This compound is utilized in research to assess drug purity and stability, as well as to study potential side effects and metabolic pathways related to Methotrexate. Its characterization is critical for quality control and regulatory compliance in pharmaceutical formulations.

Ethyl methanesulfonate is a potent alkylating agent known for its ability to induce DNA damage. By modifying DNA structure through alkylation, it triggers apoptosis and can lead to mutations and cell death. This compound is extensively utilized in genetic toxicology research to facilitate the study of gene function, mechanisms of genetic diseases, and the impacts of environmental mutagens on cellular systems. Additionally, it has been shown to induce tumors in kidney and nervous system tissues, highlighting its relevance in cancer research.

CCT-010354 is a chemical intermediate utilized in the synthesis of PPARα/δ dual agonists. This compound plays a key role in the development of therapeutics targeting metabolic disorders and inflammatory diseases, where modulation of peroxisome proliferator-activated receptors (PPARs) is beneficial. Its application in drug development underscores its significance in pharmaceutical research.

1,1'-(Azodicarbonyl)-dipiperidine (ADDP) functions as a versatile reagent in biochemical assays, primarily utilized for the condensation reactions of alcohols with acidic compounds. This compound is instrumental in the synthesis of GPR120 agonists, which exhibit antidiabetic properties, as well as in the development of triple agonists targeting PPARα, PPARγ, and PPARδ. ADDP is particularly valuable for research in metabolic diseases, facilitating advancements in therapeutic discovery.

DMT-2'-F-6-chloro-dA phosphoramidite is a specialized phosphoramidite used for the synthesis of oligonucleotides. Its incorporation into oligonucleotide sequences allows for the introduction of fluorinated modifications, enhancing stability and specificity. This reagent is essential for chemical biology applications and the development of nucleic acid-based therapeutics.

2,4-Dihydroxybenzaldehyde serves as a drug intermediate with applications in the synthesis of various Schiff base compounds. This compound demonstrates notable anti-angiogenic, anti-inflammatory, and analgesic activities, attributed to its ability to inhibit the expression of iNOS and COX-2, thus reducing the production of nitric oxide and reactive oxygen species. It is widely utilized in research focused on inflammatory conditions, contributing to the understanding of mechanisms underlying these diseases.

2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer designed for oligonucleotide synthesis. This compound incorporates a 2'-O-methyl modification and a benzoyl protective group, enhancing the stability and efficiency of synthesized oligonucleotides. It is highly relevant in research applications involving gene expression studies, antisense oligonucleotide design, and RNA interference.

DMT-dG(ib) Phosphoramidite is a phosphoramidite monomer utilized in the synthesis of DNA and nucleic acid derivatives. It serves as a key building block for creating oligonucleotides, enabling researchers to investigate genetic sequences and design nucleic acid-based applications. This reagent is essential for studies in genomics, molecular biology, and various therapeutic research areas.

DMT-dA(bz) Phosphoramidite is a key reagent utilized in the chemical synthesis of DNA. This phosphoramidite derivative features a dimethoxytrityl (DMT) group, which enhances the protection of the nucleobase during oligonucleotide assembly. It plays a crucial role in facilitating the incorporation of 2'-deoxyadenosine with a benzoyl protecting group, making it valuable for applications in molecular biology, genetics, and biochemistry research.