TRi-1

Catalog No.: A18556

TXNRD1 inhibitor

TRi-1

TRi-1 Chemical Structure

CAS NO. 246020-68-8

TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.

Availability: In stock

Package Price Qty
5 mg
$160.00
10 mg
$260.00
50 mg
$580.00
100 mg
$880.00
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Biological Activity

TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.
In vitro DMSO 25 mg/mL (76.04 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.42 mL 152.1 mL 304.2 mL
0.5 mM 6.08 mL 30.42 mL 60.84 mL
1 mM 3.04 mL 15.21 mL 30.42 mL
5 mM 0.61 mL 3.04 mL 6.08 mL

*The above data is based on the productmolecular weight 328.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18556
Actions Inhibitor
CAS No. 246020-68-8
Formula C12H9ClN2O5S
M. Wt 328.73
Solubility DMSO
Purity >98%
Synonyms TRi1
SMILES O=[N+](C1=CC=C(OC)N=C1S(=O)(C2=CC=C(Cl)C=C2)=O)[O-]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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