Catalog No.
Product Name
Application
Product Information
Citations
-
SE inhibitor
NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway. - Pafuramidine is an orally bioavailable prodrug of furamidine, which has clinical activity against Pneumocystis pneumonia.
- Retinyl glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals.
- sodium 4-pentynoate is a alkynylacetate analogue; can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types.
- Sodium formononetin-3'-sulfonate is a water-sol. derivate of formononetin.
-
Morphine-like substance
Beta-lipotropin (beta-LPH) was found to contain within its C-terminal sequence the primary structure of these peptides. -
Cell adhesion inhibitor
K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1beta or TNF-alpha. -
DNA repair inhibitor
KRX-0402 is a small molecule that was specifically designed to block the DNA repair protein, MGMT. MGMT confers resistance to certain alkylating agents, such as temozolomide and BCNU, that are commonly used to treat brain cancer, melanoma and non-Hodgkin?€?s lymphoma. -
Drug Intermediate
CCT-010354 is a chemical intermediate utilized in the synthesis of PPARα/δ dual agonists. This compound plays a key role in the development of therapeutics targeting metabolic disorders and inflammatory diseases, where modulation of peroxisome proliferator-activated receptors (PPARs) is beneficial. Its application in drug development underscores its significance in pharmaceutical research. -
Biochemical Assay Reagents
1,1'-(Azodicarbonyl)-dipiperidine (ADDP) functions as a versatile reagent in biochemical assays, primarily utilized for the condensation reactions of alcohols with acidic compounds. This compound is instrumental in the synthesis of GPR120 agonists, which exhibit antidiabetic properties, as well as in the development of triple agonists targeting PPARα, PPARγ, and PPARδ. ADDP is particularly valuable for research in metabolic diseases, facilitating advancements in therapeutic discovery. -
Phosphoramidites
DMT-2'-F-6-chloro-dA phosphoramidite is a specialized phosphoramidite used for the synthesis of oligonucleotides. Its incorporation into oligonucleotide sequences allows for the introduction of fluorinated modifications, enhancing stability and specificity. This reagent is essential for chemical biology applications and the development of nucleic acid-based therapeutics. -
Drug Intermediate
2,4-Dihydroxybenzaldehyde serves as a drug intermediate with applications in the synthesis of various Schiff base compounds. This compound demonstrates notable anti-angiogenic, anti-inflammatory, and analgesic activities, attributed to its ability to inhibit the expression of iNOS and COX-2, thus reducing the production of nitric oxide and reactive oxygen species. It is widely utilized in research focused on inflammatory conditions, contributing to the understanding of mechanisms underlying these diseases. -
Phosphoramidite Monomer
2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer designed for oligonucleotide synthesis. This compound incorporates a 2'-O-methyl modification and a benzoyl protective group, enhancing the stability and efficiency of synthesized oligonucleotides. It is highly relevant in research applications involving gene expression studies, antisense oligonucleotide design, and RNA interference. -
Phosphoramidite Monomer
DMT-dG(ib) Phosphoramidite is a phosphoramidite monomer utilized in the synthesis of DNA and nucleic acid derivatives. It serves as a key building block for creating oligonucleotides, enabling researchers to investigate genetic sequences and design nucleic acid-based applications. This reagent is essential for studies in genomics, molecular biology, and various therapeutic research areas. -
Biochemical Assay Reagent
DMT-dA(bz) Phosphoramidite is a key reagent utilized in the chemical synthesis of DNA. This phosphoramidite derivative features a dimethoxytrityl (DMT) group, which enhances the protection of the nucleobase during oligonucleotide assembly. It plays a crucial role in facilitating the incorporation of 2'-deoxyadenosine with a benzoyl protecting group, making it valuable for applications in molecular biology, genetics, and biochemistry research. -
Biochemical Assay Reagent
DMT-dT Phosphoramidite is a key reagent used in the chemical synthesis of DNA. It functions as a phosphoramidite nucleotide that facilitates the incorporation of deoxythymidine into oligomeric sequences during solid-phase synthesis. This compound is essential for applications in genetic research, molecular diagnostics, and the development of nucleic acid-based therapies. -
Phosphoramidite
Bz-rA Phosphoramidite is a phosphoramidite that features a 5' DMT and adenosine (A) with benzoyl (Bz) base protection. This reagent is specifically designed for the efficient synthesis of oligonucleotides. Its reliable incorporation of benzoyl-protected adenosine monomers facilitates studies in gene expression, molecular biology, and nucleic acid research. -
Phosphoramidite Derivative
DMT-dC(ac) Phosphoramidite is a phosphoramidite derivative primarily utilized in oligonucleotide synthesis. This compound serves as a protected form of deoxycytidine and plays a critical role in facilitating the incorporation of dC residues during the assembly of nucleic acid strands. Its use in solid-phase synthesis enables researchers to create diverse oligonucleotides for applications in molecular biology and genetic research. -
Phosphoramidite Monomer
DMT-2'-F-Bz-dA is a phosphoramidite monomer utilized in the synthesis of oligonucleotides. This compound features a 2'-fluoro substitution, which enhances the stability and specificity of nucleic acid interactions. It is particularly valuable in the design of modified oligonucleotides for applications in gene editing, antisense technologies, and molecular diagnostics. -
Phosphoramidites
2-O-DMT-Sulfonyldiethanol phosphoramidite is a phosphoramidite reagent essential for oligonucleotide synthesis. Its primary mechanism involves the formation of phosphodiester linkages, facilitating the assembly of nucleic acid sequences. This compound is widely utilized in molecular biology for the development of DNA and RNA oligonucleotides for research applications, including gene expression studies and therapeutic development. -
Phosphoramidite
Dmt-2'-f-dc(ac) amidite is a phosphoramidite used in the synthesis of cyclic purine dinucleotides. This compound facilitates the incorporation of modified nucleotides in oligonucleotide synthesis, allowing for enhanced stability and altered biological activity in nucleic acid studies. Its applications extend to research in nucleic acid therapeutics, gene regulation, and other molecular biology fields. -
Drug Intermediate
Kanjone is a chemical intermediate derived from Millettia peguensis, primarily utilized in the synthesis of protein tyrosine phosphatase 1B (PTP1B) inhibitors. This compound exhibits potential therapeutic implications for the study of diabetes and neurological disorders, facilitating research into the modulation of PTP1B activity. Its application serves as a valuable tool in advancing understanding of metabolic regulation and neurodegenerative diseases. -
Cetirizine Impurity
Cetirizine methyl ester is a known impurity of Cetirizine, a second-generation antihistamine that functions as a selective, orally active, and long-lasting antagonist of the histamine H1 receptor. This compound serves as an important analytical reference for the study of Cetirizine's purity and quality control processes. Its relevance in biochemical research and pharmaceutical development makes it a valuable tool for investigating the pharmacological profile of antihistamines. -
Biochemical Reagent
L-Ascorbic acid calcium dihydrate functions primarily as a biochemical reagent. This compound serves as a stable source of Vitamin C, acting as a potent antioxidant that scavenges free radicals and reduces oxidative stress. It plays a crucial role in collagen synthesis and is widely utilized in various life science research applications, including studies on cellular metabolism, skin health, and enzymatic reactions. -
Biochemical Reagent
Ap2A disodium is a symmetrical dinucleoside polyphosphate that serves as a biochemical reagent. It exhibits a significant capacity to promote the proliferation of vascular smooth muscle cells. This compound is commonly utilized in research focused on cellular growth and cardiovascular studies. -
Biochemical Assay Reagent
Chitin, derived from crab carapace, is a long-chain polymer of N-acetylglucosamine featuring β-(1-4) linkages. This biopolymer serves as a biochemical assay reagent and is noted for its ability to inhibit the activation of NF-κB p65, as well as alter its translocation to the nucleus. Chitin also interacts with the cell wall of Candida species, exhibiting antifungal and anti-inflammatory properties. It is valuable for research into gastric ulcers and candidiasis, contributing to the understanding of related pathophysiological processes. -
Biochemical Assay Reagent
Ammonium bicarbonate is an analytical reagent used primarily in biochemical assays. It exhibits antifungal activity and is instrumental in various research applications, including laboratory analysis and food processing. Additionally, it serves as a nitrogen source in agricultural fertilization. This reagent's high purity ensures reliable results in experimental setups. -
Biochemical Assay Reagent
Chitosan (≥95% deacetylated, viscosity 100-200 mPa.s) is a biopolymer derived from the deacetylation of chitin, targeting a wide range of microorganisms. It demonstrates notable antimicrobial properties against various bacteria and fungi, making it suitable for a variety of biochemical assays and applications. Its unique properties also lend themselves to research in drug delivery, wound healing, and food preservation. -
Biochemical Assay Reagent
L-Ascorbic acid magnesium serves as an essential biochemical assay reagent and functions as an electron donor and endogenous antioxidant. It selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM, highlighting its pharmacological significance. Additionally, L-Ascorbic acid promotes collagen deposition while inhibiting elastin production. Its anticancer properties are attributed to the generation of reactive oxygen species (ROS), which selectively induce damage in cancer cells, making it a valuable tool for research in cellular and molecular biology. -
Impurity of Hydroxychloroquine
Hydroxychloroquine Impurity E is a chemical impurity associated with Hydroxychloroquine, a synthetic antimalarial agent. Hydroxychloroquine is known to inhibit Toll-like receptor 7/9 (TLR7/9) signaling and has demonstrated efficacy in reducing SARS-CoV-2 infection in vitro. This impurity may be useful for studies investigating the purity and activity of Hydroxychloroquine in various biological contexts. -
Biochemical Assay Reagent
Lactobionic acid calcium dihydrate is a biomimetic acid that primarily acts as a biochemical assay reagent. This compound exhibits antioxidant and antimicrobial properties, making it useful in various research applications, including food safety and functional product development. Additionally, it has demonstrated the ability to inhibit DNA repair and protein synthesis, as well as induce oxidative stress and block specific metabolic pathways against methicillin-resistant Staphylococcus aureus (MRSA). Lactobionic acid calcium dihydrate can be sourced through electrolytic methods, microbial fermentation, or biocatalytic approaches. -
Biochemical Assay Reagent
Cephalin from bovine brain is a phospholipid that serves as a key biochemical assay reagent. It plays a crucial role in the formation of autophagosome membranes by acting as a lipid anchor for the autophagy-related protein Atg8/LC3. This compound enhances autophagic flux, facilitates cell differentiation, regulates lipid droplet fusion, and influences lipid metabolism, contributing to membrane integrity and potential anti-aging effects. Its applications in research include studies on autophagy, lipid metabolism, and cellular differentiation. -
Phosphoramidite Monomer
2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer targeting oligonucleotide synthesis. This reagent is instrumental in the production of RNA oligonucleotides, offering enhanced stability and improved biochemical properties. Its applications include the development of antiviral agents and therapeutics through the manipulation of RNA structures. -
dIPhosphoramidite
DMT-dA(PAc) Phosphoramidite is a dIPhosphoramidite that serves as an essential building block for the synthesis of DNA and RNA oligonucleotides. This reagent is specifically designed to facilitate the incorporation of deoxyadenosine into nucleic acid sequences, providing researchers with the ability to produce modified oligonucleotides for various applications, including genetic engineering, antisense therapy, and molecular diagnostics. Its protective groups ensure stable synthesis while maintaining high efficiency in coupling reactions. -
Phosphoramidite Monomer
S-cEt-U phosphoramidite is a modified phosphoramidite monomer designed for use in oligonucleotide synthesis. This reagent facilitates the incorporation of modified nucleotides into DNA or RNA sequences, expanding the versatility of synthetic oligonucleotides. Its application is critical in various fields, including gene therapy, antisense oligonucleotide development, and the creation of innovative bioconjugates. -
Phosphoramidites
DMT-2'-F-dA(bz) phosphoramidite is a phosphoramidite specifically designed for the synthesis of oligonucleotides. This compound facilitates the incorporation of 2'-fluoro-deoxyadenosine residues into nucleic acid sequences, enhancing the stability and biological activity of the resulting oligonucleotides. Its applications are significant in fields such as gene therapy, antisense oligonucleotide research, and RNA interference studies. -
Phosphoramidites
DMT-2'O-Methyl-rC(tac) Phosphoramidite is a specialized phosphoramidite utilized in the synthesis of oligonucleotides. This compound facilitates the incorporation of 2'-O-methyl modified ribonucleosides, enhancing the stability and binding affinity of RNA sequences. Its applications are significant in molecular biology for constructing RNA oligonucleotides with improved properties for research and therapeutic purposes. -
Biochemical Reagent
Cytarabine-daunorubicin, also known as CPX-351, is a liposomal formulation that synergistically combines cytarabine and daunorubicin in a 5:1 ratio. This targeted delivery system enhances the concentration of both compounds in leukemia cells while minimizing exposure to normal bone marrow cells. It is utilized in research focused on leukemia treatment and mechanisms, making it a valuable tool for investigating therapeutic strategies and drug efficacy in hematological malignancies. -
Phosphoramidite Monomer
DMT-dI Phosphoramidite is a modified phosphoramidite monomer that serves as a key building block in oligonucleotide synthesis. This compound facilitates the efficient incorporation of deoxyinosine into nucleic acid strands, enhancing the diversity of synthetic oligonucleotides. Its application is essential for various research areas, including gene synthesis, RNA interference studies, and the development of diagnostic tools. -
Cytosine Phosphoramidite
Ac-rC Phosphoramidite is a cytosine phosphoramidite utilized in the chemical synthesis of RNA oligonucleotides. It facilitates the incorporation of cytidine nucleotides into synthetic RNA strands while maintaining the structural integrity of the molecule during complex synthetic procedures through its specialized protecting groups. This reagent is essential for advances in RNA-based research and applications in genetic engineering and antiviral studies. -
Phosphoramidite Monomer
Fmoc-protected DMT-Dt PEG2 NH2 amidite is a phosphoramidite monomer designed for oligonucleotide synthesis. This compound features a protective Fmoc group and a PEG2 linker, enhancing solubility and facilitating the incorporation of amine functionalities into nucleic acids. It is ideal for applications in DNA and RNA synthesis, enabling the development of complex oligonucleotide structures for research in genomics and therapeutic applications.
