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Catalog No.
Product Name
Application
Product Information
Citations
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Caspase Inhibitor
Penicillic acid is a polyketide mycotoxin that serves as a caspase inhibitor. This compound demonstrates cytotoxic effects in rat alveolar macrophages, inhibiting Fas ligand-induced apoptosis through the blockade of caspase-8 self-processing. Its unique mechanism contributes to research in apoptosis and inflammation pathways, making it a valuable tool for studying cell death regulation in various biological contexts. -
Caspase-3 Inhibitor
M826 is a selective, reversible non-peptide inhibitor of caspase-3, exhibiting an IC50 value of 0.005 μM. This compound demonstrates significant anti-apoptotic activity, both in vitro and in vivo, making it a valuable tool for studying apoptosis-related pathways. M826 is particularly relevant for research into nervous system diseases, offering potential insights into therapeutic strategies targeting apoptotic processes. -
Caspase Inhibitor
Boc-Asp(OBzl)-CMK is a selective inhibitor of interleukin-1 converting enzyme (ICE, caspase-1). This compound effectively prevents cell death in CHP100 neuroblastoma cells and inhibits the release of IL-1β triggered by viral coat proteins. It serves as a valuable tool for researching inflammatory pathways and apoptotic processes in various biological contexts. -
Caspase Inhibitor
IDN-1965 is an irreversible broad-spectrum inhibitor of caspases, crucial proteases involved in apoptosis. By inhibiting caspase activity, IDN-1965 effectively delays cytochrome c release and prevents downstream apoptotic processes, such as DNase activation. In preclinical studies, this compound has demonstrated a significant reduction in cardiomyocyte apoptosis, mitigating left ventricular dilation, systolic dysfunction, and fibrosis in models of dilated cardiomyopathy. IDN-1965 is valuable for research into apoptosis-related conditions, including heart failure and the underlying mechanisms of apoptosis initiation. -
Caspase-3/7 Inhibitor
Ac-DNLD-CHO is a potent inhibitor of Caspase-3 and Caspase-7, exhibiting IC50 values of 9.89 nM and 245 nM, respectively, with corresponding Kiapp values of 0.68 nM and 55.7 nM. This reagent is valuable for investigating the role of caspase enzymes in apoptotic pathways and is particularly relevant in the study of diseases characterized by caspase-mediated cell death, including neurodegenerative disorders and viral infections. Researchers can utilize Ac-DNLD-CHO to explore therapeutic approaches targeting apoptosis in various health conditions. -
Caspase-3 Inhibitor
M867 is a selective and reversible inhibitor of caspase-3, displaying an IC50 of 1.4 nM and a Ki of 0.7 nM. This compound demonstrates anti-apoptotic activity, making it a valuable tool for research focused on cell survival and apoptosis regulation. M867 is particularly relevant for studies exploring neurodegenerative diseases, cancer research, and therapeutic interventions targeting apoptotic pathways. -
Caspase Inhibitor
Ac-YVAD-AOM is a selective inhibitor of caspase-1, a key enzyme involved in the inflammatory response and apoptosis. This compound demonstrates significant antitumor activity, making it a valuable tool for researchers studying cell death pathways and inflammatory diseases. Its specificity for caspase-1 enables detailed investigations into its role in various biological processes and therapeutic applications. -
Caspase Inhibitor
Ac-YVAD-AMC is a potent caspase inhibitor that specifically targets the caspase-1 enzyme. It is widely used in research to study the mechanisms of apoptosis and inflammation, particularly in investigations of hypersensitive response (HR) cells. By preventing caspase-mediated cell death, Ac-YVAD-AMC is valuable for elucidating the role of caspases in various biological processes and for exploring potential therapeutic strategies in diseases characterized by dysregulated apoptosis. -
Caspase-3/7 Inhibitor
Caspase-3/7 Inhibitor I is a reversible inhibitor targeting caspase-3 and caspase-7, exhibiting Ki values of 60 nM and 170 nM, respectively. This compound effectively inhibits apoptosis in various cellular models, including Camptothecin-treated Jurkat cells and chondrocytes. It serves as a valuable tool for studying mechanisms of cell death and developing therapeutic strategies against apoptotic diseases. -
Caspase-3 Inhibitor
Ac-DEVD-CMK is a selective and irreversible inhibitor of caspase-3, making it a valuable tool for research involving apoptosis. This compound effectively prevents apoptosis triggered by elevated glucose levels and the presence of Ingenol 3,20-dibenzoate. Ac-DEVD-CMK is suitable for diverse experimental applications aimed at studying apoptotic pathways and evaluating potential therapeutic interventions. -
Etoposide/Obatoclax/Caspase-3 Inhibitor
M190S is a selective inhibitor of Caspase-3, demonstrating significant protection against mitochondria-dependent apoptosis in both in vitro and in vivo models. This small molecule is poised to serve as an essential research tool for elucidating mechanisms of cell death and for the development of therapeutics that target mitochondria-dependent apoptotic pathways. M190S also exhibits favorable oral bioavailability and excellent brain permeability, enhancing its potential utility in neurological research applications. -
Caspase-1 Inhibitor
Ac-Tyr-Val-Lys-Asp-aldehyde is a reversible caspase-1 inhibitor, primarily targeting the caspase-1 enzyme. This compound plays a significant role in increasing GATA1 levels and enhancing erythroid differentiation. It is particularly useful in research applications pertaining to anemias associated with chronic diseases, chemotherapy-induced anemia, and Diamond-Blackfan anemia. -
Caspase-4 Inhibitor
Ac-LEVD-CHO is a potent inhibitor of caspase-4, designed to selectively target this key protease involved in the apoptotic pathway. This peptide, comprising the sequence Ac-Leu-Glu-Val-Asp-al, effectively blocks caspase-4 activity, making it valuable for studies investigating apoptosis and inflammation. It serves as a useful tool for researchers examining the role of caspases in various biological processes and potential therapeutic interventions in related diseases. -
Caspase-1 Inhibitor
CZL55 is a potent inhibitor of caspase-1, exhibiting an IC50 value of 24 nM. It plays a crucial role in modulating inflammatory pathways and apoptosis, making it valuable for studies related to febrile seizures (FS). This compound is useful for researchers investigating the underlying mechanisms of caspase-1 mediated processes in various pathological conditions. -
Caspase3 Inhibitor
(Rac)-M826 is a selective and reversible inhibitor of caspase-3, exhibiting an IC50 value of 0.005 μM. This compound effectively inhibits apoptosis in NT2 cells, making it a valuable tool for research into nervous system diseases. Its specificity for caspase-3 positions it as a significant reagent for studies related to cell survival and neurodegenerative conditions. -
Caspase Inhibitor
Z-Asp-CH2-DCB is an irreversible inhibitor targeting caspases, with broad-spectrum activity against proteases possessing caspase-like functions. This compound effectively blocks the production of pro-inflammatory cytokines such as IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B-stimulated peripheral blood mononuclear cells, while also reducing SEB-induced T-cell proliferation in a dose-dependent manner. Additionally, Z-Asp-CH2-DCB mitigates SU5416-induced septal cell apoptosis and the development of emphysema, making it a valuable tool in apoptosis and inflammatory research applications. -
Caspase-10 Inhibitor
Z-AEVD-FMK is a specific inhibitor of caspase-10, playing a critical role in the regulation of apoptosis. By inhibiting caspase-10, Z-AEVD-FMK effectively prevents the activation of Bid and the subsequent release of apoptosis-inducing factor (AIF) from mitochondria. This action leads to a notable reduction in apoptotic cell populations, making it a valuable tool for investigating apoptotic pathways and potential therapeutic interventions in related diseases. -
Caspase Inhibitor
Z-VAD is an irreversible pan-caspase inhibitor that targets multiple caspases, including caspase-3, -6, -7, -8, and -9, while exhibiting a lesser inhibitory effect on caspase-2. This compound is utilized in research for its ability to block apoptosis signaling pathways, promote autophagy and necrosis in tumor cells, and exhibit anti-angiogenic properties. Z-VAD enhances the sensitivity of breast and lung cancer cells to radiotherapy, both in vitro and in vivo, and extends growth delay in tumor xenograft models. It is primarily employed in studies focused on cancer radiosensitization and the regulation of cell death pathways. -
Caspase 8 Inhibitor
Caspase 8 Inhibitor CASP8-IN-1 (Compound 63-R) selectively inhibits caspase 8 with an IC50 value of 0.7 μM. This compound is effective in blocking FasL-induced apoptosis in Jurkat cells, making it a valuable tool for studying apoptotic signaling pathways and cellular responses to death stimuli. Its specificity and potency make CASP8-IN-1 suitable for research applications in cancer biology and therapeutic development targeting caspase-mediated cell death. -
DPP4 Inhibitor
DPP4-In hydrochloride is a selective inhibitor of dipeptidyl peptidase 4 (DPP4), an enzyme that plays a critical role in glucose metabolism and immune regulation. By inhibiting DPP4, this compound can effectively increase the levels of active incretin hormones, which may contribute to improved glycemic control. DPP4-In hydrochloride is primarily utilized in diabetes research and can aid in the investigation of metabolic disorders and potential therapeutic strategies for type 2 diabetes. -
Tyrosinase Inhibitor
2-Ketoglutaric Acid Potassium is a reversible and orally active inhibitor of tyrosinase, exhibiting an IC50 value of 15 mM. As a key intermediate in the Krebs cycle, it plays a role in ATP and GTP production and serves as a major carbon skeleton for nitrogen-assimilatory reactions. In addition to its enzymatic inhibition, 2-Ketoglutaric Acid Potassium has demonstrated the ability to suppress abnormal intestinal permeability and the expression of TNFα, both in vitro and in vivo. Its therapeutic applications extend to alleviating symptoms of inflammatory bowel disease (IBD) and rebalance of gut microbiota. -
MMP Inhibitor
Ecliptasaponin A is a pentacyclic triterpenoid saponin that functions as a robust inhibitor of matrix metalloproteinases (MMPs). It demonstrates significant anti-tumor properties by activating the ASK1/JNK pathway, leading to apoptosis and autophagy in lung cancer cells. Additionally, Ecliptasaponin A exerts anti-inflammatory and anti-fibrotic effects by inhibiting the HMGB1/TLR4/NF-κB signaling pathway, impacting COX-2 and MMP-9 expression. Its chondroprotective effects are attributed to the downregulation of MMP13 and modulation of inflammatory factors, while it also promotes ovarian function by enhancing ESR1 receptor expression. -
HDAC6/Proteasome Inhibitor
AMC-3-030 is a selective inhibitor targeting histone deacetylase 6 (HDAC6) and the chymotrypsin-like activity of the proteasome, demonstrating IC50 values of 884 nM and 4.17 nM, respectively. This compound exhibits a proliferative inhibitory effect and has been shown to reduce levels of α-tubulin and β-actin. AMC-3-030 serves as a valuable tool for investigating mechanisms related to multiple myeloma and other related research applications. -
DHODH Inhibitor
Olorofim is a selective inhibitor of dihydroorotate dehydrogenase (DHODH), a crucial enzyme in the pyrimidine biosynthesis pathway. It demonstrates potent antifungal activity, particularly against Aspergillus fumigatus and other species within the Aspergillus genus. Olorofim is a valuable tool for research focused on fungal infections and the development of antifungal therapies. -
DHODH Inhibitor
DHODH-IN-33 is a selective inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting potent anti-cancer activity with IC50 values of 5.22 μM in A549 cells and 3.03 μM in 5637 cells. This compound induces autophagy-dependent ferroptosis characterized by mitochondrial dysfunction, lipid peroxidation, and reactive oxygen species (ROS) accumulation, while demonstrating minimal toxicity in vivo. DHODH-IN-33 is a valuable tool for researching therapeutic strategies targeting non-small cell lung cancer and bladder cancer through the autophagy-mediated degradation of DHODH. -
Tyrosinase Inhibitor
Deoxyarbutin is a potent tyrosinase inhibitor, primarily utilized in dermatological and cancer research. It promotes apoptosis in melanoma cells and enhances the vitality of mouse acinar cells, exhibiting significant skin whitening effects and anti-tumor activity. This compound is valuable for studies focused on skin disorders and melanoma treatment strategies. -
Mushroom Tyrosinase Inhibitor
Dihydroaltenuene B is a potent inhibitor of mushroom tyrosinase, exhibiting an IC50 of 38.33 µM. This compound interacts with active site residues, including His244, Met280, and Gly281, through hydrogen bonding with its 3-OH and 4'-OH groups. Dihydroaltenuene B serves as a valuable reagent for investigating tyrosinase-related enzymatic processes and offers potential applications in skin-whitening agents and studies on melanin biosynthesis inhibition. -
MMP-9 inhibitor
MMP-9-IN-1 is a selective inhibitor of matrix metalloproteinase-9 (MMP-9) that specifically targets the hemopexin (PEX) domain of MMP-9, without affecting other MMP family members. -
MMP Inhibitor/PPARα Agonists
Auraptene is an orally active geranyloxycoumarin compound naturally found in plants of the *Brassicaceae* family. It exhibits a wide range of biological activities, including antibacterial, anti-pathogenic, antioxidant, anti-tumor, and neuroprotective effects. Auraptene has shown therapeutic potential in the management of various chronic conditions such as hypertension and cystic fibrosis, making it a valuable compound for pharmacological and nutraceutical research. -
Caspase-1 inhibitor
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective, irreversible inhibitor of caspase-1 (also known as IL-1β converting enzyme, ICE). It exhibits potent neuroprotective and anti-inflammatory effects by suppressing the expression of proinflammatory cytokines IL-1β and IL-18. Ac-YVAD-cmk also inhibits pyroptosis, a form of inflammatory cell death, making it a valuable tool for studying inflammation-related diseases and neurodegenerative disorders. -
Cathepsin L inhibitor
Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific inhibitor of cathepsin L (CTSL), a lysosomal cysteine protease involved in protein degradation and various pathological processes. It is commonly used as a tool compound in studies of CTSL-related functions and diseases. -
SHP2 inhibitor
Migoprotafib (GDC-1971; compound 199) is a selective SHP2 inhibitor that suppresses the MAPK/ERK signaling pathway. It exhibits antitumor activity and is under investigation for its potential in targeting SHP2-driven cancers. -
PGAM1 inhibitor
HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1) that induces apoptosis and suppresses cell migration by inhibiting the formation of invasive pseudopodia. It increases oxidative stress, activates the JNK/c-Jun pathway, and downregulates AKT and ERK signaling. HKB99 is a promising compound for the study of non-small cell lung cancer (NSCLC). -
Endoplasmic Reticulum Stress Inhibitor
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an inhibitor of endoplasmic reticulum (ER) stress that significantly downregulates pro-apoptotic molecules, including caspase-3 and caspase-12. Additionally, it suppresses ERK signaling, contributing to its cytoprotective and anti-apoptotic effects. -
ADAM17 inhibitor
JG26 is a potent ADAM inhibitor with IC50 values of 12 nM for ADAM8, 1.9 nM for ADAM17, and 150 nM for ADAM10. It also inhibits MMP-12 with an IC50 of 9.4 nM. JG26 suppresses AngII-induced EGFR transactivation and ERK activation, upregulates ACE2 expression, inhibits CD23 shedding, and reduces SARS-CoV-2 infection. Additionally, JG26 demonstrates anti-metastatic effects in colorectal cancer and holds research potential in Hodgkin lymphoma and vascular diseases. -
HIV-1 protease/PTP1B inhibitor
Isosinensetin is a bioactive flavonoid compound with diverse pharmacological properties. It acts as a dual inhibitor of HIV-1 protease and protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 2.61 µM and a Kᵢ of 0.92 µM for PTP1B, indicating its potential in antiviral and metabolic disease research. Additionally, isosinensetin inhibits P-glycoprotein (P-gp) activity in MDR1-MDCKII cells, suggesting its utility in overcoming multidrug resistance. Isosinensetin exhibits multiple therapeutic effects, including anti-tumor, anti-viral, anti-inflammatory, and antioxidant activities. These properties support its application in the research of various conditions such as cancer, chronic inflammation, osteoporosis, diabetes, and infectious diseases. -
Phosphatase inhibitor
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a widely used phosphatase inhibitor. It plays a critical role in promoting and sustaining osteoblast differentiation, supporting mineral metabolism, and modulating cellular signal transduction pathways. In tissue engineering and drug delivery, it is commonly utilized as a component in the formation of heat-sensitive hydrogels due to its thermoresponsive properties. Additionally, β-glycerophosphate disodium salt accelerates calcification in vascular smooth muscle cells, making it a valuable tool for studying vascular calcification and related pathologies. -
COX-1/HDAC/Tyrosinase Inhibitor
Gnetol is a bioactive phenolic compound isolated from the root of *Gnetum montanum* with diverse pharmacological properties. It potently inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 0.78 μM and exhibits histone deacetylase (HDAC) inhibitory activity. Gnetol is also a strong tyrosinase inhibitor, with an IC₅₀ of 4.5 μM against murine tyrosinase, leading to suppression of melanin biosynthesis. In addition to its antioxidant, antiproliferative, anticancer, and hepatoprotective effects, Gnetol modulates metabolic enzymes in a concentration-dependent manner, including α-amylase, α-glucosidase, and adipogenesis pathways, making it a promising candidate for research in oncology, dermatology, and metabolic disorders. -
COX-2/MMP-7/TLR4 Inhibitor
Isofraxidin is a coumarin compound derived from *Acanthopanax senticosus* that exhibits anti-invasive and anti-inflammatory properties. It inhibits MMP-7 expression and suppresses cell invasion in human hepatoma cells by reducing ERK1/2 phosphorylation. Isofraxidin also downregulates the expression of iNOS and COX-2 and inhibits the formation of the TLR4/myeloid differentiation protein-2 (MD-2) complex. -
Nek1 Inhibitor
BSc5367 is a potent inhibitor of NIMA-related protein kinase 1 (Nek1), exhibiting an IC50 of 11.5 nM. Nek1 is integral to cell cycle regulation, DNA repair, and microtubule dynamics, with its dysfunction implicated in various conditions such as amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD), and radiotherapy-resistant cancers. This reagent is valuable for research into the molecular mechanisms underlying these diseases and for exploring potential therapeutic interventions. -
Nek7 Inhibitor
Ofirnoflastum is a selective inhibitor of the serine/threonine-protein kinase Nek7. This compound demonstrates significant anti-inflammatory properties, making it a valuable tool for research into inflammation-related pathways and diseases. Its mechanism of action and specificity towards Nek7 facilitate investigations in various cellular processes, particularly those associated with cellular stress responses and mitotic regulation. -
NEK6 Inhibitor
ZINC05007751 is a selective inhibitor of the NIMA-related kinase NEK6, exhibiting an IC50 of 3.4 μM. This compound demonstrates notable antiproliferative effects across various human cancer cell lines and synergizes with Cisplatin and Paclitaxel in BRCA2-mutated ovarian cancer models. ZINC05007751 displays high specificity for NEK6 and NEK1, with minimal activity against NEK2, NEK7, and NEK9, making it a valuable tool for studying NEK6-related pathways in cancer research. -
Hec1/Nek2 Inhibitor
Nek2/Hec1-IN-3 is a potent inhibitor of the Hec1/Nek2 interaction, specifically designed to disrupt the binding between these two proteins. This compound exhibits significant biological activity by interfering with the Nek2-mediated regulation of cell division, making it a valuable tool for research in neoplastic diseases and cancer biology. Its application in studying tumorigenesis and cell cycle dysregulation facilitates a deeper understanding of oncogenic pathways. -
Nek2 Inhibitor
JH295 hydrate is a selective and irreversible inhibitor of NIMA-related kinase 2 (Nek2), exhibiting an IC50 value of 770 nM. This compound targets cellular Nek2 by inducing alkylation at Cys22, while showing no activity against critical mitotic kinases such as Cdk1, Aurora B, or Plk1, thereby maintaining bipolar spindle assembly and the spindle assembly checkpoint. Additionally, JH295 hydrate functions as a click chemistry reagent, possessing an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it valuable in various research applications. -
Nek2/Hec1 Inhibitor
Nek2/Hec1-IN-2 is a potent inhibitor of the Nek2 and Hec1 kinases. It effectively disrupts cell division processes, demonstrating inhibitory activity against cancer cell proliferation with an IC50 greater than 25 μM. This compound is valuable for research into mitotic regulation and therapeutic strategies targeting cancer cell growth. -
Nek2 Inhibitor
HCI-2184 is a potent Nek2 inhibitor with an IC50 value of 39.90 nM. This compound enhances the efficacy of Bortezomib by significantly inhibiting proteasome activity. HCI-2184 is valuable for research applications focused on cell cycle regulation and cancer therapeutics. -
Nek2 Inhibitor
Nek2-IN-6 is a selective inhibitor of never in mitosis (NIMA) related kinase 2 (Nek2), a critical regulator of mitotic processes. This compound demonstrates significant biological activity in inhibiting this kinase, making it valuable for exploring its role in cell division and related pathologies. Nek2-IN-6 is well-suited for research applications focused on cancer biology, particularly in studies examining the mitotic spindle assembly and its implications in tumorigenesis. -
NEK7 Inhibitor
NEK7-IN-1 is a potent inhibitor of NIMA-related kinase 7 (NEK7), exhibiting an IC50 of less than 100 nM. It effectively suppresses the release of IL-1β, with an IC50 of less than 50 nM. This compound is valuable for research into inflammatory responses and the molecular pathways involving NEK7. Its application extends to studies focused on cellular processes influenced by NEK7 modulation. -
Nek2 Inhibitor
Nek2-IN-5 is a potent and irreversible inhibitor of Nek2 (Never in mitosis gene a-related kinase 2). This compound features a clickable alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules. Nek2-IN-5 is valuable in research applications focused on cell cycle regulation and cancer biology, providing insights into the role of Nek2 in cellular processes.
