Target & Activity
| Target | Activity | Value |
|---|---|---|
| MMP-2 | IC50 | 0.81 nM |
| MMP13 | IC50 | 0.56 nM |
| MMP-8 | IC50 | 10.8 nM |
| MMP-9 | IC50 | 18 nM |
| MMP-3 | IC50 | 120 nM |
| MMP-1 | IC50 | 1900 nM |
6 targets · Scroll to view more
Fig. 1 · Structure
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XL-784
MMP inhibitor
XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13 respectively.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1224964-36-6 |
| Applications | MMP inhibitor |
| Formula | C21H22ClF2N3O8S |
| Molecular Weight | 549.93 |
| SMILES | COCCOC(=O)N1CCN(C(C1)C(=O)NO)S(=O)(=O)C2=CC(=C(C(=C2)F)OC3=CC=C(C=C3)Cl)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.