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PGMI-004A

Name: PGMI-004A
Brand: Adooq Bioscience
SKU: A20561
Availability: InStock

Cat. No. A20561 CAS 1313738-90-7

PGAM1 inhibitor

PGMI-004A is a potent phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC50 of 13.1 μM.

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Biological Activity

Cellular Effect

Cell Line	Activity	Value	Description	Reference
A549	EC50	38.7 μM	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 36215859]
KG-1a	EC50	17.1 μM	Antiproliferative activity against human KG-1a cells assessed as decrease in cell viability incubated for 72 hrs by trypan blue exclusion assay	[PMID: 36215859]
MCF7	IC50	> 40 μM	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 29530347]
NCI-H1299	EC50	25.6 μM	Antiproliferative activity against human NCI-H1299 cells assessed as decrease in cell viability incubated for 72 hrs by trypan blue exclusion assay	[PMID: 36215859]
PANC-1	IC50	32 μM	Antiproliferative activity against human PANC1 cells after 72 hrs by MTT assay	[PMID: 29530347]
PC-9	EC50	17.81 μM	Antiproliferative activity against human PC-9 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 36215859]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1313738-90-7
Applications	PGAM1 inhibitor
Formula	C₂₁H₁₂F₃NO₆S
Molecular Weight	463.38
SMILES	O=S(C(C=C1C2=O)=C(O)C(O)=C1C(C3=C2C=CC=C3)=O)(NC4=CC=C(C(F)(F)F)C=C4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.