Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC HPK1 Degrader
HPK1-IN-47 is a selective HPK1 ligand designed for the synthesis of PROTACs, specifically serving as a precursor for PROTAC HPK1 Degrader-2. It exhibits potential in targeting HPK1, which plays a significant role in various HPK1-mediated diseases, particularly cancer. This compound is valuable for research applications focused on elucidating the therapeutic potential of HPK1 degradation in cancer treatment. -
PROTAC HPK1 Degrader
PROTAC HPK1 Degrader-6 is a potent PROTAC compound designed to selectively target and degrade the HPK1 protein, exhibiting an IC50 of less than 50 nM. This compound facilitates the investigation of HPK1's role in leukemia and other related disorders. By employing the dual binding mechanism to HPK1 and the E3 ligase CRBN, it serves as a valuable tool for researchers exploring targeted protein degradation as a therapeutic strategy. -
PROTAC HPK1 Degrader
DD205-291 is an orally active PROTAC HPK1 degrader that exhibits a DC50 value of 5.3 nM. Its primary mechanism involves the targeted degradation of HPK1, leading to the inhibition of SLP-76 phosphorylation. This modulation subsequently results in the enhanced expression of key cytokines such as IL-2 and IFN-γ, making DD205-291 a valuable reagent for studies in immune signaling and related therapeutic applications. -
Ligands for Target Protein for PROTAC
PD0325901-O-C2-dioxolane is a derivative of the MEK inhibitor PD0325901, designed as a ligand for targeted protein degradation in conjunction with VHL or CRBN E3 ligases. This compound facilitates the synthesis of MEK1/2 degraders, enabling the selective degradation of MEK proteins in experimental studies. Its application in research provides critical insights into MEK-related signaling pathways and their role in various diseases, particularly in cancer biology. -
MEK1/2 PROTAC Degrader
MS910 is a potent and selective PROTAC degrader targeting MEK1 and MEK2 kinases. It demonstrates effective degradation of MEK1 and MEK2 in various cancer cell lines, with reported DC50 values of 118 nM for MEK1 and 55 nM for MEK2 in HT-29 cells, and 94 nM for MEK1 and 38 nM for MEK2 in SK-MEL-28 cells. MS910 is primarily utilized in cancer research to explore the therapeutic potential of targeted protein degradation. -
Mixed Lineage Kinase PROTAC Degrader
PROTAC MLKL Degrader-1 selectively targets and degrades MLKL, achieving a maximum efficacy (Dmax) greater than 90%. This compound incorporates modified CRBN ligands and linker components, functioning effectively in cellular models. PROTAC MLKL Degrader-1 effectively inhibits cell death in a TNF-α, Smac, and zVAD (TSZ) model of necroptosis, making it a valuable tool for investigating necroptosis pathways and their implications in various diseases. -
Ligand for Target Protein for PROTAC
PROTAC SOS1 ligand 1 is a high-affinity ligand for the SOS1 protein, facilitating targeted protein degradation through PROTAC technology. This compound is instrumental in the development of therapeutic strategies by enabling the selective modulation of SOS1, which plays a pivotal role in various oncogenic signaling pathways. Researchers can utilize this reagent in studies focused on cancer biology and drug discovery, particularly in exploring novel approaches to target and degrade specific proteins associated with tumor progression. -
PROTAC CYP1B1 Degrader
PROTAC CYP1B1 Degrader-1 is a targeted degrader designed to selectively eliminate cytochrome P450 1B1 (CYP1B1), utilizing a α-naphthoflavone chimera derivative. This compound exhibits IC50 values of 95.1 nM for CYP1B1 and 9838.6 nM for CYP1A2, demonstrating its specificity in degrading CYP1B1. It serves as a valuable tool for investigating the role of CYP1B1 in prostate cancer and may aid in overcoming CYP1B1-mediated drug resistance in therapeutic applications. -
PROTAC Linker
(2E,9Z)-Octadeca-2,9-dienoic acid serves as a PROTAC linker in chemical research applications. This polyunsaturated fatty acid plays a critical role in lipoxygenase-dependent metabolic processes, facilitating the study of enzyme-modulating pathways. Its unique structure enables the development of targeted protein degradation strategies in cellular systems. -
MALT1 PROTAC Degrader
PROTAC MALT1 Degrader-1 is a selective degrader targeting MALT1 through the use of the PROTAC (proteolysis targeting chimera) technology. This compound facilitates the ubiquitination and subsequent proteasomal degradation of MALT1, making it a valuable tool for studies focused on lymphoma and related malignancies. Its mechanism of action enables the investigation of MALT1's role in cellular processes and therapeutic strategies for lymphoma treatment. -
PROTAC Linkers
m-PEG-NHS ester (MW 5000) is a PEGylated linker that facilitates the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an N-hydroxysuccinimide (NHS) functional group, enabling efficient coupling to amine-containing substrates. Its hydrophilic nature enhances solubility and improves pharmacokinetic properties, making it an essential tool for researchers in targeted protein degradation and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-C5-COOH is an E3 ligase ligand-linker conjugate designed for the construction of PROTACs. It incorporates the VH032 VHL-based ligand, which is a selective and potent inhibitor of the VHL/HIF-1α interaction with a Kd of 185 nM. This compound is valuable for investigating models of anemia and ischemic diseases, providing a tool for targeted protein degradation research. -
STING Molecular Glue
NVS-STG2 is a molecular glue that targets the STING receptor by binding to the interstitial regions of adjacent STING dimers, thereby enhancing STING signaling. This compound promotes the activity of cGAMP, leading to the formation of larger and more stable oligomers, which amplifies the immune response. NVS-STG2 has demonstrated significant antitumor effects in preclinical animal models, making it a valuable tool for cancer immunotherapy research. -
STING PROTAC Degrader
PROTAC STING degrader-3 is a potent STING PROTAC degrader that operates through the ubiquitin-proteasome pathway, exhibiting a DC50 of 0.62 μM. This compound facilitates STING degradation, resulting in the inhibition of STING/TBK1/NF-κB signaling, thereby exerting notable anti-inflammatory effects. Additionally, PROTAC STING degrader-3 demonstrates renal protective properties and serves as a valuable tool for investigating acute kidney injury (AKI). -
PROTAC STING Degrader
PROTAC STING Degrader-2 is a targeted protein degrader that specifically induces the degradation of the Stimulator of Interferon Genes (STING) through a covalent interaction with STING and an E3 ubiquitin ligase. With a DC50 value of 0.53 μM, this compound facilitates the study of STING's biological functions, particularly in the context of autoinflammatory and autoimmune diseases. This reagent is instrumental for researchers exploring the therapeutic potential and role of STING in immune regulation. -
cGAS PROTAC Degrader
PROTAC cGAS degrader-1 is a selective degrader targeting cGAS through a proteolysis-targeting chimera (PROTAC) mechanism. It effectively induces proteasome-mediated degradation of cGAS, leading to the inhibition of the cGAS signaling pathway and a reduction in double-stranded DNA-induced cGAS activation in both human and mouse cell models. This compound is particularly relevant for research applications in inflammatory diseases such as ulcerative colitis. -
PROTAC
PTOTAC HSD17B13 degrader 1 is a PROTAC designed to selectively target and promote the degradation of 17β-Hydroxysteroid dehydrogenase 13 (HSD17B13). This compound consists of a specific ligand for HSD17B13, a linker based on tert-Butyl 5-bromoisoindoline-2-carboxylate, and a ligand for an E3 ubiquitin ligase, enabling effective ubiquitination and subsequent proteasomal degradation of the target protein. PTOTAC HSD17B13 degrader 1 is a valuable tool for studying HSD17B13 functions and has potential applications in therapeutic development and protein regulation research. -
PROTAC Linker
Ms-PEG8-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a Boc-protected amine that facilitates conjugation to target proteins, enhancing the efficient recruitment of E3 ligases. Ms-PEG8-Boc plays a critical role in research applications focused on targeted protein degradation, enabling the study of protein function and therapeutic development in various disease models. -
PROTAC Linkers
m-PEG2-Amino is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies by providing a flexible and hydrophilic backbone. Its application in the construction of PROTACs enables researchers to enhance the selectivity and efficacy of targeted therapies. -
PROTAC Linker
Succinamic acid functions primarily as a linker in the construction of PROTAC molecules. This compound has been characterized as a weak inhibitor of human LL-xylose reductase, exhibiting an IC50 value of 1.45 mM. Its structural properties make it instrumental in synthesizing compounds such as CQ-16, facilitating advancements in targeted protein degradation research. -
PROTAC Linker
Azido-PEG9-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, facilitating the conjugation of alkyne- or DBCO/BCN-containing molecules, respectively. Its versatility makes Azido-PEG9-Boc a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linkers
(+)-Biotin-PEG2-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent degradation. Its application is critical in the development of novel therapeutic strategies for various diseases, particularly in the field of targeted protein degradation research. -
PROTAC linker
N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a PEG-based linker designed for PROTAC synthesis. It features an azide functional group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds. This versatile linker is valuable for optimizing PROTAC constructs in chemical biology research. -
PROTAC Linker
Boc-NHCH2-Ph-pyrimidine-NH2 serves as a versatile linker for PROTAC (Proteolysis Targeting Chimeras) applications. By facilitating the conjugation of target proteins with E3 ligases, this compound enhances the selective degradation of proteins of interest. Its unique structure allows for improved target engagement and therapeutic potency, making it an essential tool for drug discovery and chemical biology research focused on targeted protein degradation. -
PROTAC Linker
N-Boc-N-bis(PEG3-azide) is a PEG-based PROTAC linker that facilitates the synthesis of targeted protein degraders. This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for researchers in the field of protein degradation and chemical biology. -
PROTAC Linkers
N-Me-N-bis-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby enhancing the targeted degradation of specific proteins in cellular studies. Its application is crucial in the development of innovative therapeutics that modulate protein levels to investigate biological pathways and disease mechanisms. -
PROTAC linker
Boc-N-Amido-PEG5-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ligases, enhancing targeted therapeutic strategies in chemical biology. Its application extends to various fields including drug discovery and the development of novel therapeutic agents aimed at specific molecular targets. -
PROTAC Linkers
Propargyl-PEG11-methane serves as a versatile PEG-based linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC design makes it a valuable reagent for targeted protein degradation studies and drug discovery research. -
PROTAC Linker
m-PEG4-propargyl is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. Featuring an alkyne group, this compound serves as a click chemistry reagent, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is instrumental in the development of targeted protein degradation strategies and can be utilized in various research applications focusing on protein modulation and therapeutic discovery. -
PROTAC Linker
N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the development of PROTAC (proteolysis-targeting chimeras) applications. This compound facilitates the conjugation of ligand-recruiting components to E3 ligase adapters, enabling targeted protein degradation mechanisms. Its flexible PEG structure enhances solubility and biocompatibility, making it suitable for various biochemical and pharmacological investigations in drug discovery and development. -
PROTAC Linker
Boc-Aminooxy-PEG1-C2-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of proteins within cellular systems. It is an essential tool for researchers investigating targeted protein modulation and ubiquitin-proteasome system dynamics. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the development of targeted protein degradation strategies by linking proteins of interest to E3 ligases, enhancing their ubiquitination and subsequent degradation. Its unique trifluoroethyl moiety provides distinct chemical properties that may improve solubility and linker stability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linkers
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based linker designed for the synthesis of PROTACs. This reagent features a DBCO group that allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its biotin component enhances labeling and purification processes, making it valuable in target protein degradation studies and other biochemical applications. -
PROTAC Linkers
Boc-NH-PEG10-CH2CH2COOH is a polyethylene glycol (PEG)-derived linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and pharmacokinetic properties of PROTACs, promoting efficient protein degradation and targeted therapeutic efficacy. Its carboxylic acid functionality facilitates conjugation to target ligands, making it a valuable tool in chemical biology and drug discovery research focused on novel therapeutics. -
PROTAC Linkers
Benzyl-PEG24-MS is a PEG-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the precise conjugation of target protein ligands and ubiquitin E3 ligase binding domains, enhancing the design of bifunctional molecules for targeted protein degradation. Its unique structure allows for increased solubility and improved biocompatibility, making it suitable for various applications in the study of targeted therapies and protein modulation. -
PROTAC Linkers
Amino-PEG23-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligand and E3 ligase components, enhancing the selective degradation of target proteins. Its unique structural properties make it suitable for various applications in target protein modulation and therapeutic development. -
PROTAC Linkers
TCO-PEG6-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This intermediary compound facilitates the conjugation of targeting ligands to E3 ligases, thereby enhancing the efficiency of targeted protein degradation. Its versatile applications in drug discovery make it a valuable tool for researchers investigating protein modulation and degradation pathways. -
PROTAC Linkers
6-Maleimidocaproic acid-PFP ester is a versatile PROTAC linker that features an alkyl chain structure. It facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs) by enabling the conjugation of target proteins to E3 ligases. This reagent is essential for applications in targeted protein degradation studies and can enhance the development of novel therapeutics in cancer research and other diseases. -
PROTAC Linker
3-Hydroxyazetidine-Cyclohexanol serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its chemical structure is designed to enhance the efficacy of targeted protein degradation, making it a valuable tool in drug discovery and development research. This compound is instrumental in the synthesis of ALK PROTACs, contributing to advancements in targeted therapies for various cancers. -
PROTAC Linker
Benzyl-PEG8-THP is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound promotes the targeted degradation of specific proteins through an E3 ubiquitin ligase-mediated pathway. Its application is essential in drug discovery and development for creating novel therapeutics that modulate protein levels in a highly selective manner. -
PROTAC Linker
Ald-Ph-amido-C2-PEG3-NH-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of targeted protein degradation systems by connecting target proteins to E3 ligases. It enhances selectivity and efficiency in protein degradation studies, making it a valuable tool for research in targeted therapeutics and cellular pathways. -
PROTAC linker
Hydroxy-Amino-bis(PEG2-propargyl) serves as a PEG-based PROTAC linker, facilitating the design of proteolysis-targeting chimeras (PROTACs). This versatile compound features an alkyne moiety, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application in research supports the development of targeted protein degradation strategies, enhancing the exploration of protein functions and therapeutic interventions. -
PROTAC Linkers
Thiol-C9-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of selected proteins within cellular systems. This compound is essential for researchers exploring targeted protein degradation and related therapeutic modalities in various biological contexts. -
PROTAC Linkers
CHO-CH2-PEG1-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the development of bifunctional molecules that promote targeted degradation of specific proteins, enabling innovative therapeutic strategies. Its hydrophilic nature enhances solubility, making it suitable for various biological applications in chemical biology and medicinal chemistry research. -
PROTAC Linker
Azide-PEG7-Tos is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its versatility in click chemistry expands the potential for targeted protein degradation studies, making it an essential tool for researchers in areas such as drug discovery and targeted therapy development. -
PROTAC Linkers
Bromo-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase recruiting components, enhancing the efficacy of targeted protein degradation. Its versatile chemical properties make it suitable for various applications in chemical biology research, particularly in the development of novel therapeutics focusing on selective protein modulation. -
PROTAC Linkers
Hydroxy-PEG12-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, thereby promoting targeted degradation pathways. Hydroxy-PEG12-Boc enhances cellular permeability and solubility of PROTACs, making it essential for studies in targeted protein degradation and cellular biotechnology research. -
PROTAC Linker
Azido-PEG3-phosphonic acid ethyl ester is a PEG-based linker designed for PROTAC synthesis, targeting the ubiquitin-proteasome system to facilitate protein degradation. This compound features an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that possess DBCO or BCN groups, making it a valuable tool for developing targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Azido-PEG8-C1-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds. Its versatility in click chemistry makes it an invaluable tool for researchers focused on targeted protein degradation and biochemical studies. -
PROTAC Linkers
Benzyl-PEG9-Ots is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by linking E3 ligase adapters to a specific protein of interest. Its application in PROTAC development enables advancements in cellular research and therapeutic strategies by modulating protein levels within biological systems.
