Fig. 1 · Structure
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PROTAC cGAS degrader-1
cGAS PROTAC Degrader
PROTAC cGAS degrader-1 is a selective degrader targeting cGAS through a proteolysis-targeting chimera (PROTAC) mechanism. It effectively induces proteasome-mediated degradation of cGAS, leading to the inhibition of the cGAS signaling pathway and a reduction in double-stranded DNA-induced cGAS activation in both human and mouse cell models. This compound is particularly relevant for research applications in inflammatory diseases such as ulcerative colitis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3118499-89-8 |
| Applications | cGAS PROTAC Degrader |
| Formula | C36H33Cl2N7O5 |
| Molecular Weight | 714.60 |
| SMILES | ClC1=CC(C2=NN(C=C2)C)=C3C(NC4=C3CN(CC4)C(CNC(CCCC#CC5=C(C6=CC=C5)CN(C6=O)C7CCC(NC7=O)=O)=O)=O)=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.