Documents & Downloads

PROTAC HPK1 Degrader-6

PROTAC HPK1 Degrader

PROTAC HPK1 Degrader-6 is a potent PROTAC compound designed to selectively target and degrade the HPK1 protein, exhibiting an IC50 of less than 50 nM. This compound facilitates the investigation of HPK1's role in leukemia and other related disorders. By employing the dual binding mechanism to HPK1 and the E3 ligase CRBN, it serves as a valuable tool for researchers exploring targeted protein degradation as a therapeutic strategy.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3099168-12-1
Applications	PROTAC HPK1 Degrader
Formula	C₄₁H₄₃N₉O₃
Molecular Weight	709.84
SMILES	O=C(N1)N(C2=CC=C(C3CCN(C4CN(C5=CC=C(NC6=NC=C7C=CC(C8=CN=C9OCCNC9=C8C)=CC7=N6)C=C5)C4)CC3)C=C2C)CCC1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.