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PTOTAC HSD17B13 degrader 1

PROTAC

PTOTAC HSD17B13 degrader 1 is a PROTAC designed to selectively target and promote the degradation of 17β-Hydroxysteroid dehydrogenase 13 (HSD17B13). This compound consists of a specific ligand for HSD17B13, a linker based on tert-Butyl 5-bromoisoindoline-2-carboxylate, and a ligand for an E3 ubiquitin ligase, enabling effective ubiquitination and subsequent proteasomal degradation of the target protein. PTOTAC HSD17B13 degrader 1 is a valuable tool for studying HSD17B13 functions and has potential applications in therapeutic development and protein regulation research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3046195-01-8
Applications	PROTAC
Formula	C₄₅H₄₅ClF₃N₇O₅
Molecular Weight	856.33
SMILES	O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C(CCCN4CC5=CC(C6=CC7=NN([C@@H]8CC[C@H](CC8)CNC(C9=C(C(F)=C(C(F)=C9)O)F)=O)C=C7C=C6)=CC=C5C4)C=C3N1C.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.