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DD205-291

PROTAC HPK1 Degrader

DD205-291 is an orally active PROTAC HPK1 degrader that exhibits a DC50 value of 5.3 nM. Its primary mechanism involves the targeted degradation of HPK1, leading to the inhibition of SLP-76 phosphorylation. This modulation subsequently results in the enhanced expression of key cytokines such as IL-2 and IFN-γ, making DD205-291 a valuable reagent for studies in immune signaling and related therapeutic applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3047066-15-6
Applications	PROTAC HPK1 Degrader
Formula	C₃₈H₃₈ClF₃N₁₀O₃
Molecular Weight	775.22
SMILES	O=C(N1)N(C2=C(C=CC(C(N3CCC(CC3)CC4CCN(CC4)C5=CC=C(C=N5)C6=NC7=C(NC=C7C8=CN(N=C8)CC(F)(F)F)N=C6)=O)=C2)Cl)CCC1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.