Fig. 1 · Structure
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Azido-PEG3-phosphonic acid ethyl ester
PROTAC Linker
Azido-PEG3-phosphonic acid ethyl ester is a PEG-based linker designed for PROTAC synthesis, targeting the ubiquitin-proteasome system to facilitate protein degradation. This compound features an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that possess DBCO or BCN groups, making it a valuable tool for developing targeted protein degradation strategies in chemical biology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1337527-24-8 |
| Applications | PROTAC Linker |
| Formula | C12H26N3O6P |
| Molecular Weight | 339.33 |
| SMILES | O=P(OCC)(CCOCCOCCOCCN=[N+]=[N-])OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.