Catalog No.
Product Name
Application
Product Information
Citations
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Target Protein Ligand-Linker Conjugates
K-Ras ligand-Linker Conjugate 3 is designed to selectively target K-Ras through its ligand, combined with a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This reagent is instrumental in the development of PROTAC-based degraders, particularly in the synthesis of PROTAC K-Ras Degrader-1, which demonstrates significant degradation efficacy of ≥70% in SW1573 cells. This compound is essential for research applications in targeted protein degradation and cancer therapeutics involving K-Ras. -
Target Protein Ligand-Linker Conjugate
USP7 Ligand-Linker Conjugates 1 is a targeted protein ligand-linker conjugate designed to bind to the deubiquitinating enzyme USP7. This compound incorporates a specific USP7 ligand and a PROTAC linker that facilitates the recruitment of E3 ligases for targeted protein degradation. It serves as a crucial component in the synthesis of PROTAC USP7 Degrader-1, enabling researchers to investigate the functional role of USP7 in cellular processes and its potential as a therapeutic target. -
Target Protein Ligand-Linker Conjugate
(Rac)-PROTAC PARP/EGFR ligand 1 is a target protein ligand-linker conjugate that features ligands for both PARP and EGFR, along with a PROTAC linker to facilitate the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This reagent is instrumental in the advancement of targeted protein degradation strategies in research, enabling the synthesis of DP-C-4, a CRBN-based dual PROTAC designed for the simultaneous degradation of EGFR and PARP. Its application in drug discovery highlights its utility in elucidating the roles of these critical proteins in cancer biology. -
Target Protein Ligand-Linker Conjugates
K-Ras ligand-Linker Conjugate 2 is designed to specifically target K-Ras by integrating a selective ligand with a PROTAC linker that facilitates the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This conjugate serves as a critical precursor for the synthesis of PROTAC K-Ras Degrader-1, demonstrating significant biological activity by achieving ≥70% degradation efficiency in SW1573 cancer cells. It is a valuable tool for research focused on protein degradation and therapeutic strategies for K-Ras-driven cancers. -
Target Protein Ligand-Linker Conjugates
BMS-1166-N-piperidine-CO-N-piperazine serves as a targeted ligand-linker conjugate for the PD-1/PD-L1 immune checkpoint pathway. This compound is designed to facilitate the synthesis of a PROTAC PD-1/PD-L1 degrader, exhibiting potent inhibition of the PD-1/PD-L1 interaction with an IC50 value of 39.2 nM. Its applications are particularly relevant in cancer research, where modulating immune checkpoint pathways is critical for therapeutic intervention and study of immune evasion mechanisms. -
Target Protein Ligand-Linker Conjugates
K-Ras ligand-Linker Conjugate 1 is designed to target the K-Ras protein through a specific ligand, while also incorporating a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This reagent is essential for the synthesis of PROTAC K-Ras Degrader-1, a potent degrader that demonstrates greater than 70% degradation efficacy in SW1573 cells. It serves as a valuable tool for researchers investigating K-Ras-related pathways and exploring targeted protein degradation strategies. -
Target Protein Ligand-Linker Conjugates
K-Ras ligand-Linker Conjugate 4 functions as a targeted protein ligand-linker conjugate designed for K-Ras. This compound incorporates a ligand to effectively recruit K-Ras and a PROTAC linker that interacts with E3 ligases such as VHL, CRBN, MDM2, and IAP. It serves as a synthetic precursor for PROTAC K-Ras Degrader-1, demonstrating significant biological activity with at least 70% degradation efficacy in SW1573 cells. This conjugate is essential for research into targeted protein degradation and the modulation of K-Ras-related pathways. -
Target Protein Ligand-Linker Conjugates
DDR1 ligand 1-piperidine is a target protein ligand and linker conjugate designed for use in the development of PROTACs targeting DDR1. This compound facilitates the synthesis of DDR1 degrader-1, enabling research into targeted protein degradation and modulation of DDR1-related signaling pathways. Its application is crucial for studies exploring the therapeutic potential of DDR1 inhibition in various disease models. -
Target Protein Ligand-Linker Conjugates
FAK ligand-2-C6-amine is a target protein ligand-linker conjugate that incorporates a focal adhesion kinase (FAK) ligand with a PROTAC linker. This compound effectively recruits E3 ligases, facilitating the targeted degradation of specific proteins. FAK ligand-2-C6-amine is valuable in research applications focused on protein regulation and cellular signaling pathways, and it can be utilized in the synthesis of BSJ-04-146, a compound of interest in cancer research. -
Conjugate
Ahx-DM1 is a versatile conjugate designed for the targeted delivery of therapeutic, diagnostic, or labeling agents. By facilitating effective conjugation with proteins or peptides, this compound enhances the specificity and efficacy of treatments in chemical research. Its applications extend to areas such as drug development and imaging, making it an essential tool for advancing biomedical studies and experimental therapies. -
Target Protein Ligand-Linker Conjugate
Remodelin-C6-COOH is a synthesized ligand-linker conjugate designed for conjugation with target proteins. This compound facilitates the synthesis of NP1192, a potent NAT10 PROTAC degrader known for its anti-tumor activity. Remodelin-C6-COOH serves as an essential tool in the development of targeted protein degradation strategies for cancer research. -
Target Protein Ligand-Linker Conjugates
SMARCA2/4 Ligand-Linker Conjugate 2 is a specialized ligand-linker conjugate designed for targeting SMARCA2 and SMARCA4 proteins. This compound facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs), specifically enabling the development of AU-15330. It is a valuable tool in chemical biology for studying protein degradation pathways and investigating the functional roles of SMARCA family proteins in various cellular processes. -
Target Protein Ligand-Linker Conjugate
JQ-1 (carboxylic acid)-NH-C8-COOH is a synthetic linker designed for conjugation with target proteins. This compound facilitates the synthesis of JQ1-S(GlcNAc)Cq, a bifunctional degrader that exhibits significant anti-tumor activity through its Sugar-Coated PROTAC mechanism. It serves as a valuable tool in chemical research focused on targeted protein degradation and cancer biology applications. -
Target Protein Ligand-Linker Conjugate
AZD9496-O-C3-O-C3-O-C-acid is a targeted protein ligand-linker conjugate that includes a ligand specific for estrogen receptor alpha (ERα) and a PROTAC linker designed to recruit E3 ligases. This compound facilitates the development of PROTAC AZ'6421, enabling researchers to investigate targeted protein degradation pathways. It is applicable in studies focusing on hormone receptor modulation and protein regulation in cellular contexts. -
PROTAC E3 Ligases and Linkers
Adamantane-Butyl alcohol serves as a crucial linker for PROTACs targeting E3 ligases, specifically in the degradation of the CDK8-cyclin C complex. This compound facilitates targeted protein degradation, thereby enhancing the modulation of cellular processes and offering a strategic approach in research applications such as cancer biology and therapeutic development. Its selective and persistent nature makes it an integral component in the design of novel protein degraders. -
Target Protein Ligand-Linker Conjugates
BRAF ligand-Linker Conjugate 1 is a compound designed to target the BRAF protein through a ligand-linker approach. It serves as a crucial precursor for the synthesis of PROTAC CST905, facilitating targeted protein degradation. This reagent is applicable in studies focused on BRAF-related signaling pathways and therapeutic interventions for diseases associated with BRAF mutations. -
Target Protein Ligand-Linker Conjugate
TEAD ligand-Linker Conjugate 1 is a synthetic ligand-linker conjugate designed for the development of PROTACs, specifically for creating PROTAC TEAD degrader-2, which demonstrates potent degradation of the TEAD1 protein. This compound is pivotal for anti-cancer research, facilitating targeted protein degradation to study TEAD1’s role in cancer progression and therapeutic responses. Its application in PROTAC technology presents opportunities for innovative approaches in cancer treatment and molecular biology research. -
Conjugate
Ahx-DM1 TFA is a conjugate designed for the covalent attachment of proteins or peptides to therapeutic, diagnostic, or labeling agents. This compound facilitates the targeted delivery of payloads in biological applications, enhancing the efficacy of treatments. Its structural properties enable effective conjugation, making it suitable for research in drug development and protein engineering. -
Target Protein Ligand-Linker Conjugates Chemical
BRD4 ligand-Linker Conjugate 1 is a ligand-linker conjugate specifically designed for targeting the BRD4 protein. This compound plays a crucial role in the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating targeted protein degradation. Its application is instrumental in studying BRD4-related signaling pathways and advancing drug discovery efforts in cancer and other diseases associated with epigenetic dysregulation. -
E3 Ligase Ligand-Linker Conjugates
DCAF11 ligand-Linker Conjugate 1 is a conjugate designed to facilitate targeted protein degradation through the DCAF11 E3 ubiquitin ligase. This compound serves as a key component for synthesizing PROTAC LGF308, enabling the selective degradation of specific proteins within cellular systems. Its utility in research applications includes the exploration of protein degradation pathways and investigating therapeutic targets in cancer and other diseases. -
Ligand-Linker Conjugate
N-Descyclopropanecarbaldehyde Olaparib suberic acid is a ligand-linker conjugate designed for the synthesis of DDO3602. This compound functions as a crucial intermediate, facilitating the development of targeted therapeutics that leverage olaparib’s mechanism of action. Its versatility makes it relevant for applications in drug discovery and conjugation chemistry in the context of cancer research. -
BRM2 Degrader
PROTAC SMARCA2 degrader-1 is a targeted degrader designed to selectively degrade BRM2 (SMARCA2) with a DC50 value of less than 0.1 μM. This compound functions as an E3 ubiquitin ligase binding linker, facilitating the targeted degradation of specific proteins. Its application in cancer research makes it a valuable tool for elucidating the role of BRM2 in tumor biology and developing potential therapeutic strategies. -
PROTAC GPX4 Degrader
PROTAC GPX4 degrader-5 is a selective degrader targeting GPX4, with a DC50 of 28 nM. This compound effectively induces ferroptosis and enhances reactive oxygen species (ROS) levels while exhibiting low toxicity to normal cells. PROTAC GPX4 degrader-5 demonstrates significant anti-proliferative effects in various tumor cell lines, making it a valuable tool for cancer research. -
SKP2 Molecular Glue Degrader
XMU-MP-8 is a potent molecular glue degrader that targets the oncoprotein SKP2. It binds to the F-box domain of SKP2 and the N-terminal TPR domain of the E3 ligase STUB1, facilitating the formation of a stable SKP2-SKPer1-STUB1 ternary complex. This interaction leads to SKP2 ubiquitination and subsequent proteasomal degradation, selectively eliminating SKP2-expressing cancer cells. XMU-MP-8 demonstrates significant tumor suppression and favorable safety profiles in vivo, making it a valuable tool for cancer research, particularly in studies related to non-small cell lung adenocarcinoma (NSCLC) and prostatic adenocarcinoma. -
TRIM21 Molecular Glue
HGC652 is a molecular glue degrader that specifically targets TRIM21, facilitating the disruption of nuclear membrane integrity through a TRIM21-dependent mechanism. By binding with high affinity to the PRY-SPRY domain of TRIM21, HGC652 promotes the interaction between TRIM21 and NUP98, enhancing E3 ligase activity. This results in the polyubiquitination and subsequent proteasomal degradation of nucleoporins such as NUP155 and GLE1, leading to altered nuclear morphology, enhanced genomic instability, and ultimately, cancer cell death. HGC652 serves as a valuable tool for investigating nuclear envelope dynamics and the role of TRIM21 in cancer research. -
Molecular Glue
CC-647 is a molecular glue modulator that targets the Cereblon (CRBN) E3 ubiquitin ligase. It enhances the interaction between CRBN and ZBTB16, along with its oncogenic fusion protein RARα-ZBTB16, with a DC50 of 103 nM. CC-647 is particularly valuable for the investigation of ZBTB16-RARα-associated acute promyelocytic leukemia (APL) and offers potential insights into therapeutic strategies for this malignancy. -
E3 Ligase Ligand
E3 Ligase Ligand 36 is a potent E3 ligase ligand that serves as a key substrate for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates targeted protein degradation and has been utilized in the development of PROTAC BRM/BRG1 degrader-1. This compound provides valuable tools for research in protein regulation and therapeutic applications in various diseases. -
Molecular Glues
MG Degrader 3 is a molecular glue that targets the CRBN protein, inducing targeted protein degradation. It exhibits potent anti-proliferative activity in multiple myeloma cell line MM.1S, with an IC50 of 8.7 nM. This compound is valuable for studies investigating protein degradation mechanisms and therapeutic approaches in cancer research. -
E3 Ligase Ligand-Linker Conjugate
Ethanolamine-Thalidomide-4-OH is an E3 ligase ligand-linker conjugate designed to facilitate targeted protein degradation via the proteolysis targeting chimera (PROTAC) approach. This compound combines a cereblon (CRBN) ligand with a linker, enabling the synthesis of various PROTACs, such as PROTAC BTK Degrader-13. It serves as a crucial tool for researchers investigating selective protein degradation mechanisms and developing novel therapeutic strategies. -
PROTAC Linker
Azido-PEG2-C2-amine is a PEG-based linker designed for use in PROTAC synthesis. This compound features an azide moiety that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, facilitating conjugation with alkyne-bearing molecules. Additionally, Azido-PEG2-C2-amine serves as a non-cleavable linker for the development of antibody-drug conjugates (ADCs), making it a versatile tool in chemical biology and drug discovery applications. -
ADC/PROTAC Linker
DBCO-PEG5-NHS ester is a cleavable linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This PEG/alkyl/ether-based reagent facilitates the formation of stable covalent bonds through strain-promoted alkyne-azide cycloaddition (SPAAC), targeting azide-functionalized molecules. Its defined structure enhances the efficacy and specificity of therapeutic compounds, making it a valuable tool for researchers in the development of targeted therapies. -
PROTAC Linkers
Bromo-PEG2-C2-azide is a versatile PROTAC linker featuring a bromo group and an azide moiety, designed for the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This compound functions effectively in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Bromo-PEG2-C2-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it a valuable tool for targeted protein degradation and bioconjugation strategies in chemical biology research. -
PROTAC Linker
Azido-PEG4-C2-acid is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. It serves as a non-cleavable linker in the synthesis of antibody-drug conjugates (ADCs) and is integral to the development of compounds such as vRucaparib-TP4. This compound features an azide group that enables the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, and it also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile reagent for chemical biology research. -
ADC/PROTAC Linker
Bis-PEG9-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs (proteolysis-targeting chimeras). This cleavable linker facilitates the attachment of drugs to antibodies, enhancing selective delivery and activity. Its application in PROTAC synthesis allows for targeted protein degradation, making it a valuable tool in drug discovery and development. -
PROTAC Linker
N3-PEG3-CH2CH2COOH is a PEG-based PROTAC linker that facilitates selective protein degradation by enabling the synthesis of specific PROTACs, including BI-3663 and BI-4216. This compound contains an azide group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-containing molecules. N3-PEG3-CH2CH2COOH is also applicable as a non-cleavable ADC linker in the development of antibody-drug conjugates, making it a versatile reagent for chemical biology research. -
ADC/PROTAC Linker
N-Boc-PEG1-bromide is a versatile cleavable linker targeting ADCs and PROTACs. This PEG/alkyl/ether-based reagent facilitates the synthesis of antibody-drug conjugates (ADCs) and enhances the design of proteolysis-targeting chimeras (PROTACs). Its unique properties allow for effective conjugation and release mechanisms, making it suitable for various applications in chemical biology and drug development research. -
ADC/PROTAC Linker
Bis-PEG5-NHS ester is a polyethylene glycol (PEG) based linker that targets protein degradation for the development of PROTACs (proteolysis targeting chimeras) and serves as a cleavable linker in antibody-drug conjugates (ADCs). This compound facilitates the conjugation of bioactive molecules with antibodies, enhancing the targeted delivery of therapeutic agents. Its versatile application in synthesizing both PROTACs and ADCs makes it valuable for advancing research in targeted therapies and drug delivery systems. -
PROTAC Linker
Amino-PEG4-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This linker facilitates the assembly of heterobifunctional molecules and enables targeted degradation of proteins within cellular systems. Additionally, Amino-PEG4-alcohol serves as a non-cleavable 4-unit PEG linker for the development of antibody-drug conjugates (ADCs), enhancing the delivery of therapeutic agents. It is suitable for applications in chemical biology and drug development research. -
ADC/PROTAC Linker
Azido-PEG7-amine is a non-cleavable 7-unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs (Proteolysis Targeting Chimeras). This versatile linker features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Azido-PEG7-amine serves as an important tool for the development of advanced bioconjugates in chemical research. -
PROTAC Linker
Boc-NH-PEG4-CH2CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras), facilitating targeted degradation of specific proteins. Additionally, this compound serves as a cleavable linker for antibody-drug conjugates (ADCs), enhancing the delivery of therapeutic agents to specific cellular targets. Its versatile applications make it a valuable tool in chemical biology and drug development research. -
ADC/PROTAC Linker
N-Boc-PEG4-bromide is a PEG-based linker that functions as a cleavable agent in antibody-drug conjugates (ADCs) and PROTACs. This compound facilitates the synthesis of PROTACs by providing a flexible and hydrophilic connector, enhancing solubility and biological activity. Its functional bromide group allows for effective conjugation to various biomolecules, making it a valuable tool in drug development research. -
PROTAC Linkers
Azido-PEG5-alcohol functions as a non-cleavable linker in the synthesis of antibody-drug conjugates (ADCs) and as a versatile PEG-based linker for PROTAC (proteolysis-targeting chimeras) development. It is characterized by its azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne, DBCO, or BCN-functionalized molecules. This reagent is instrumental in creating stable linkages for targeted protein degradation and therapeutic antibody conjugation, enhancing the efficacy of research applications in drug development. -
PROTAC Linkers
Azido-PEG6-amine is a PEG-based PROTAC linker featuring an azide functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-bearing and DBCO or BCN-containing molecules. This compound plays a crucial role in the synthesis of PROTACs, facilitating targeted protein degradation. Additionally, it serves as a non-cleavable linker in the development of antibody-drug conjugates (ADCs), providing significant versatility for researchers engaged in drug development and therapeutic applications. -
PROTAC Linker
Bis-PEG3-NHS ester is a non-cleavable linker that features a three-unit polyethylene glycol (PEG) structure, designed for use in the construction of PROTACs (proteolysis-targeting chimeras). This reagent facilitates the effective conjugation of antibodies to various agents, enhancing their therapeutic potential. Its unique properties make it suitable for applications in targeted drug delivery and protein degradation studies. -
Azide Compound
DBCO-PEG2-NHS ester is a click chemistry reagent with an azide group, designed to facilitate bioconjugation through reactions with primary amines, such as lysine side chains or aminosilane-coated surfaces. This PEG-based compound features an NHS ester, which enables the formation of stable covalent bonds under neutral to slightly basic conditions. The hydrophilic polyethylene glycol (PEG) spacer enhances solubility and adds flexibility, reducing steric hindrance during ligation. DBCO-PEG2-NHS ester is ideal for applications in copper-free Click Chemistry and other bioconjugation studies. -
ADC/PROTAC Linker
N-Boc-PEG2-bromide is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. Its PEG-based structure facilitates enhanced solubility and flexibility, contributing to improved therapeutic efficacy. This reagent is essential for researchers focused on developing targeted drug delivery systems and studying protein degradation pathways. -
PROTAC/ADC Linker
NH2-PEG2-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This non-cleavable linker comprises two PEG units, facilitating efficient conjugation while ensuring stability in biological systems. Its application is crucial in the development of targeted therapeutics, enabling precise modulation of protein degradation and enhancing the efficacy of ADCs in research and therapeutic contexts. -
ADC/PROTAC Linker
m-PEG5-CH2COOH is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs) and PEG-based PROTACs. It facilitates the synthesis of ADCs by enabling stable connectivity between the antibody and the cytotoxic drug. Additionally, m-PEG5-CH2COOH serves as an effective linker for the development of PROTACs, thereby supporting targeted protein degradation research. Its chemical properties enhance the overall efficacy and stability of conjugated compounds in biological applications. -
ADC/PROTAC Linker
DBCO-PEG4-DBCO is a PEG-based linker primarily designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound features a dibenzocyclooctyne (DBCO) group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its versatile reactivity enables the development of targeted therapeutics, enhancing specificity and efficacy in research applications focused on protein degradation and targeted delivery systems. -
ADC/PROTAC Linker
m-PEG2-Amine is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis and antibody-drug conjugate (ADC) development. This cleavable linker facilitates the integration of therapeutic agents with antibodies, enhancing cellular uptake and stability. m-PEG2-Amine is essential for researchers focusing on targeted protein degradation and ADC formulations in therapeutic development.
