Fig. 1 · Structure
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Pomalidomide 4'-PEG5-azide
Ligands for E3 Ligase
Pomalidomide 4'-PEG5-azide is a Pomalidomide-derived ligand specifically targeting the cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN, making it a valuable tool in the development of PROTACs by linking to proteins through a suitable linker. Its application in chemical biology research enhances understanding of protein degradation pathways and E3 ligase modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2624181-61-7 |
| Applications | Ligands for E3 Ligase |
| Formula | C25H34N6O9 |
| Molecular Weight | 562.57 |
| SMILES | [N-]=[N+]=NCCOCCOCCOCCOCCOCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.