Fig. 1 · Structure
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E3 ligase Ligand 79
Ligand For E3 Ligase
E3 ligase Ligand 79 serves as a ligand for the CRBN E3 ligase, facilitating the development of targeted protein degradation strategies. This compound is crucial for the synthesis of PROTAC CDK2/4 Degrader-1, which allows for selective degradation of protein targets in various biological contexts. Researchers can utilize this ligand to study the mechanisms of E3 ligase-mediated degradation and its potential therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2152672-96-1 |
| Applications | Ligand For E3 Ligase |
| Formula | C13H14N4O2 |
| Molecular Weight | 258.28 |
| SMILES | O=C(C(C1=NN(C)C2=C1C=CC(N)=C2)CC3)NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.