ALV2

Name: ALV2
Brand: Adooq Bioscience
SKU: A80451
Rating: 5 (288 reviews)

Catalog No.: A80451

Helios Degrader

ALV2 is a potent and selective Helios degrader that functions as a molecular glue. It exhibits an IC50 of 0.57 μM for binding to cereblon (CRBN). By targeting Helios, a zinc-finger transcription factor, ALV2 plays a crucial role in regulating the stability of Treg cell phenotype within the inflammatory tumor microenvironment, making it valuable for research in immunology and cancer therapy.

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Grouped product items
Size	Price	Stock
5mg	$370.00	In stock
10mg	$670.00	In stock
25mg	$1,385.00	In stock
50mg	$2,090.00	In stock
100mg	$3,120.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	ALV2 is a potent and selective Helios degrader that functions as a molecular glue. It exhibits an IC50 of 0.57 μM for binding to cereblon (CRBN). By targeting Helios, a zinc-finger transcription factor, ALV2 plays a crucial role in regulating the stability of Treg cell phenotype within the inflammatory tumor microenvironment, making it valuable for research in immunology and cancer therapy.

Product Information

Catalog Num	A80451
Formula	C26H26ClN5O5
Molecular Weight	523.97
CAS Number	2438124-95-7
SMILES	O=C(NC(C)(C1=CC=CC(NC2=CC(N(C(CC3)C(NC3=O)=O)C2=O)=O)=C1)C)NC4=CC=C(C)C(Cl)=C4

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