Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-566 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-566 is valuable for research focused on targeted protein degradation and the modulation of cellular pathways involving E3 ligases. -
Ligands for E3 Ligase
E3 Ligase Ligand 30 is a potent ligand for E3 ubiquitin ligases, facilitating the modulation of ubiquitination processes within cellular systems. Its primary mechanism involves binding to the E3 ligase, enhancing substrate recognition and specificity. This compound exhibits significant potential for studying protein degradation pathways and exploring targeted protein modulation in various research applications, including cancer biology and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-491 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound serves as a crucial component in the design of PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of proteins in cellular systems. Its application is significant in drug discovery and the study of ubiquitin-mediated proteolysis. -
Ligand for E3 Ligase
CRBN ligand-581 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the cereblon protein, facilitating targeted protein degradation through the formation of PROTACs (Proteolysis Targeting Chimeras). Its utility in research extends to the development of novel therapeutic strategies and the study of ubiquitin-mediated degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-235 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-235 is valuable for research in targeted protein degradation and elucidation of ubiquitin-proteasome system mechanisms. -
Ligand for E3 Ligase
CRBN ligand-320 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC that promotes the ubiquitination and subsequent degradation of the target protein. CRBN ligand-320 serves as a valuable tool for research in targeted protein degradation and cellular protein regulation. -
Ligand for E3 Ligase
CRBN ligand-286 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound enables the development of Proteolysis Targeting Chimeras (PROTACs) by linking to a target protein ligand through a suitable linker. CRBN ligand-286 is essential for studies focused on targeted protein degradation and ubiquitin-mediated proteolysis, providing valuable insights into cellular regulation and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-274 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling targeted protein degradation through the recruitment of CRBN to specific substrate proteins. It serves as a critical component in the design of PROTAC (proteolysis-targeting chimera) molecules, facilitating the ubiquitination and subsequent degradation of the target protein. This reagent is valuable for researchers investigating protein regulation and developing therapeutic strategies in oncology and other disease areas. -
Ligand for E3 Ligase
CRBN ligand-417 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, enabling targeted protein degradation through the PROTAC (Proteolysis Targeting Chimeras) approach. This compound is valuable in studying protein regulation and degradation mechanisms, making it a useful tool in cancer research and drug discovery applications. -
Ligand for E3 Ligase
CRBN ligand-608 is a highly selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of the CRBN protein. This compound can be effectively used in the synthesis of PROTACs (Proteolysis Targeting Chimeras) by linking it to target protein ligands through a suitable linker. Its application in protein degradation research provides a valuable tool for studying disease mechanisms and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-609 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker, enabling the development of Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-609 is valuable for research applications in the study of targeted therapeutics and protein homeostasis. -
Thalidomide Analog
Thalidomide-pinacolborane is a Thalidomide analogue that incorporates a boronic pinacol ester (Bpin group) and serves as an activator for E3 ligases. This compound plays a crucial role in ubiquitination, facilitating the targeted degradation of proteins through proteolytic pathways. Its applications in chemical biology include studies on protein regulation and modulation of cellular signaling processes, making it a valuable tool in research focused on proteostasis and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-262 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It serves as a crucial component in the development of Proteolysis Targeting Chimeras (PROTACs) when conjugated to target protein ligands through a linker. This compound is valuable for research applications focused on targeted protein degradation and modulation of cellular protein levels. -
Ligand for E3 Ligase
CRBN ligand-596 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-596 is valuable for research applications focused on targeted protein degradation and the study of ubiquitin-mediated processes. -
Ligand for E3 Ligase
CRBN ligand-722 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) applications, enabling the effective degradation of target proteins through ubiquitin-proteasome pathways. Its versatility makes it a valuable tool for studying protein turnover and targeted protein modulation in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-711 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-711 is valuable in research applications focusing on targeted protein degradation and therapeutic strategies involving the modulation of cellular protein levels. -
Ligand for E3 Ligase
CRBN ligand-525 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to target protein ligands through a suitable linker, enabling the formation of Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-525 is instrumental in studies focused on targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-263 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it with a target protein ligand through a suitable linker, thereby enabling targeted degradation of specific proteins. It serves as a valuable tool in biochemistry and cell biology research for studies focused on proteolysis and protein regulation. -
Ligand for E3 Ligase
CRBN ligand-288 is an E3 ubiquitin ligase ligand that selectively binds to cereblon (CRBN). This compound effectively recruits the CRBN protein, facilitating targeted protein degradation. It can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC for use in research applications focused on the modulation of protein levels and therapeutic intervention in various disease contexts. -
Ligand for E3 Ligase
CRBN ligand-503 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimeras). CRBN ligand-503 is valuable in research focused on targeted protein degradation, providing insights into ubiquitin-proteasome pathway modulation and therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-302 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation through the recruitment of CRBN. This compound can be conjugated to a target protein ligand via a linker to form a PROTAC, enabling selective degradation of specific proteins. Its applications extend to studies in drug discovery, cancer research, and functional proteomics. -
Ligand for E3 Ligase
CRBN ligand-251 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound serves as a crucial component for the development of PROTACs (proteolysis-targeting chimeras) by linking to target protein ligands through a suitable linker. Its application in chemical biology enables the modulation of protein degradation pathways, providing a valuable tool for studying protein function and therapeutic intervention in various diseases. -
Ligand for E3 Ligase
CRBN ligand-368 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), essential for targeted protein degradation. It facilitates the recruitment of the cereblon protein, enabling the construction of PROTACs (proteolysis-targeting chimeras) by linking to a target protein ligand. This compound is valuable for research in ubiquitin-proteasome system studies and in the development of therapeutic strategies leveraging targeted protein degradation. -
Ligand for E3 Ligase
CRBN ligand-531 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by connecting it to a target protein ligand through a suitable linker. Its application in drug discovery and development makes it a valuable tool for studying protein regulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-887 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be linked to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It serves as a valuable tool in chemical biology for the selective degradation of target proteins, contributing to research in targeted protein regulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-414 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein in targeted protein degradation applications. By linking CRBN ligand-414 to a target protein ligand through a suitable linker, it can be utilized to construct PROTAC molecules for the specific degradation of desired proteins. This compound is instrumental in the study of ubiquitin-proteasome pathways and has significant implications in therapeutic research and drug discovery. -
Ligand for E3 Ligase
CRBN ligand-719 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. This compound can be conjugated to target protein ligands through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). It is a valuable tool for researchers investigating protein regulation and degradation pathways in cellular biology. -
Ligand for E3 Ligase
CRBN ligand-553 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be utilized to conjugate with target protein ligands via a linker to create Proteolysis Targeting Chimeras (PROTACs). This compound is crucial for studying targeted protein degradation and has applications in drug development and cellular biology research. -
Ligand for E3 Ligase
CRBN ligand-670 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. It is valuable for research applications involving modulation of protein levels and investigation of CRBN's role in various cellular processes. -
Ligand for E3 Ligase
CRBN ligand-567 is a ligand designed to target the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to specific proteins. This compound is essential for the development of PROTACs (proteolysis-targeting chimeras), which harness the ubiquitin-proteasome system to promote the targeted degradation of proteins. Its unique properties make CRBN ligand-567 a valuable tool for researchers investigating protein regulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-601 is an E3 ubiquitin ligase cereblon (CRBN) ligand that functions by selectively recruiting the cereblon protein. This compound can be effectively conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). It serves as a valuable tool for research applications involving targeted protein degradation, providing insights into protein regulation and potential therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-593 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the CRBN protein and can be conjugated to a target protein ligand through a linker to create a PROTAC. Its unique mechanism allows for precise modulation of protein degradation pathways, making it valuable for research in targeted protein degradation and related therapeutic applications. -
Ligand for E3 Ligase
CRBN ligand-642 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). It is valuable for research applications focused on targeted protein degradation and uncovering cellular pathways associated with ubiquitination. -
Ligand for E3 Ligase
CRBN ligand-384 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound enables the synthesis of proteolysis-targeting chimeras (PROTACs) by linking with specific target protein ligands through a suitable linker. CRBN ligand-384 is significant in studying targeted protein degradation and biodegradation pathways, making it a valuable tool for researchers investigating cellular regulation and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-530 is a ligand for the cereblon (CRBN) E3 ubiquitin ligase that facilitates the recruitment of CRBN to target proteins. This compound is designed for the development of Proteolysis Targeting Chimeras (PROTACs), allowing targeted degradation of specific proteins through the ubiquitin-proteasome pathway. Its application is valuable in chemical biology and therapeutic research, particularly in studies involving targeted protein modulation. -
Ligand for E3 Ligase
CRBN ligand-476 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation provides a valuable tool for research in cellular regulation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-237 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be effectively utilized to link with a target protein ligand through a linker, enabling the formation of Proteolysis-Targeting Chimeras (PROTACs). This compound is valuable for research applications involving targeted protein degradation and the study of ubiquitin-mediated pathways. -
Ligands for E3 Ligase
Lenalidomide 4'-PEG1-amine dihydrochloride serves as a ligand for E3 ligase, specifically targeting the Cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN, enabling the development of proteolysis-targeting chimeras (PROTACs). Researchers can utilize this reagent to explore targeted protein degradation pathways and investigate potential therapeutic applications in various cancers and other diseases. -
Ligands for E3 Ligase
Lenalidomide 4'-PEG2-amine dihydrochloride is a Cereblon ligand that targets the CRBN protein, playing a crucial role in E3 ligase recruitment. This compound facilitates the development of PROTACs by linking to various target proteins through a suitable linker. It is valuable for research focused on regulated protein degradation pathways and the study of cellular processes influenced by E3 ligase activity. -
Ligands for E3 Ligase
(S,R,S)-AHPC-C2-PEG3-BCN is a ligand targeting E3 ligases, specifically the von Hippel-Lindau (VHL) E3 ligase. It plays a vital role in the synthesis of PROTACs (proteolysis-targeting chimeras), which mediate targeted degradation of proteins within cells. This compound is intended for research applications in protein degradation and cellular regulation studies. -
Ligands for E3 Ligase
Lenalidomide 4'-PEG3-amine dihydrochloride is a selective ligand for the E3 ubiquitin ligase Cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through the PROTAC (Proteolysis Targeting Chimeras) mechanism. Its application includes the development of innovative therapeutic strategies for various diseases by harnessing the ubiquitin-proteasome system for regulated protein turnover. -
CRBN Ligand
Pomalidomide-5-C6-NH2 hydrochloride is a cereblon (CRBN) ligand derived from Pomalidomide. This compound functions by facilitating the recruitment of CRBN proteins, making it an essential tool for the development of PROTAC (Proteolysis Targeting Chimeras) constructs. Its ability to form linkages with target proteins through a linker enhances its utility in targeted protein degradation research, paving the way for innovative therapeutic strategies in various diseases. -
Ligands for E3 Ligase
Pomalidomide 4'-alkylC6-azide is a cereblon (CRBN) ligand that facilitates selective protein targeting via the recruitment of the CRBN protein. It serves as a key component in the development of PROTACs (Proteolysis Targeting Chimeras), enabling targeted degradation of specific proteins. This reagent is essential for research in targeted protein degradation and the modulation of cellular pathways critical for disease mechanisms. -
CRBN Ligand
Pomalidomide-C6-COOH is a cereblon (CRBN) ligand derived from pomalidomide, designed for the specific recruitment of CRBN proteins. This compound serves as a vital building block for the development of PROTACs by enabling the conjugation of CRBN with various proteins via a linker. Its utility in targeted protein degradation makes it a valuable reagent for research applications in cellular signaling and therapeutic interventions. -
CRBN Ligand
Pomalidomide-5-C8-NH2 hydrochloride is a CRBN ligand derived from Pomalidomide. This compound facilitates the recruitment of the cereblon (CRBN) protein, enabling the design of targeted protein degradation strategies. It can be conjugated with a suitable linker to create PROTACs, which are valuable tools in therapeutic applications for modulating protein levels in various biological contexts. -
E3 Ligase Ligand-linker Conjugate
CRBN ligand-895-PEG2-N3 is a synthetic E3 ligase ligand-linker conjugate designed to facilitate the development of PROTACs. This compound plays a crucial role in the targeted degradation of proteins by linking to E3 ligases, enhancing the specificity and efficacy of degradation processes. It serves as a valuable tool for researchers investigating protein modulation and therapeutic applications in targeted protein degradation strategies. -
CRBN Ligand-Linker Conjugates
E3 Ligase Ligand-linker Conjugate 195 is a conjugate that targets cereblon (CRBN) through its ligand component. This compound facilitates the development of Proteolysis Targeting Chimeras (PROTACs) by providing a functional linker necessary for targeted protein degradation. It is suitable for research applications investigating novel therapeutic strategies in protein modulation and degradation pathways. -
Ligands for E3 Ligase
VH032-C6-NH-Boc is a Boc-modified ligand that targets the von Hippel-Lindau (VHL) E3 ligase, facilitating the recruitment of VHL proteins. Under acidic conditions, it readily deprotection occurs, allowing its direct utilization in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a crucial intermediate in developing PROTACs utilizing VHL ligands, thereby advancing research in targeted protein degradation. -
Ligands for E3 Ligase
(S,R,S)-AHPC-CO-C9-NH2 is a Von Hippel-Lindau (VHL) ligand that serves as a crucial building block for the synthesis of E3 ligase ligands utilized in the development of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the understanding of protein degradation pathways and enables targeted protein modulation, making it a valuable tool for researchers investigating targeted therapies in cancer and other diseases. -
E3 Ubiquitin Ligase Ligands and Linkers for PROTACs
E3 Ligase Ligand-linker Conjugate 139 is designed to bind to E3 ubiquitin ligases, serving as a critical component in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates ubiquitination and subsequent degradation of target proteins, making it a valuable tool for cancer research and therapeutic applications. Its unique properties enable efficient disruption of protein homeostasis, offering insights into cellular pathways and potential treatment strategies in oncology.
