Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-796 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed for use in PROTAC (PROteolysis TArgeting Chimeras) technology, allowing for the targeted degradation of proteins by linking to specific target protein ligands through a suitable linker. Its role in modulating protein degradation pathways makes it a valuable tool for research in targeted therapeutics and cellular signaling studies. -
Ligand for E3 Ligase
CRBN ligand-589 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). Its applications in chemical biology include the modulation of protein degradation pathways and the investigation of targeted protein therapy mechanisms. -
Ligand for E3 Ligase
CRBN ligand-229 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be successfully linked to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). Research applications of CRBN ligand-229 include targeted protein degradation and the study of ubiquitin-mediated proteostasis pathways. -
Ligand for E3 Ligase
CRBN ligand-858 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand through an appropriate linker. Its applications extend to advancing research in targeted protein degradation and exploring novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-644 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein to target substrates. It can be conjugated to target protein ligands through a linker to generate a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. This reagent is valuable for research in protein dynamics and therapeutic development through modulation of the ubiquitin-proteasome system. -
Ligand for E3 Ligase
CRBN ligand-718 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in cellular assays. This compound serves as a valuable tool for the development of proteolysis-targeting chimeras (PROTACs) by linking to a target protein ligand via a linker. Its applications include studying protein degradation pathways and creating innovative therapeutic strategies in targeted protein degradation research. -
Ligand for E3 Ligase
CRBN ligand-295 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of proteolysis-targeting chimeras (PROTACs). It is ideal for research applications in drug discovery and development, particularly in the study of protein homeostasis and cellular regulation. -
Ligand for E3 Ligase
CRBN ligand-290 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a building block for the development of PROTACs (Proteolysis Targeting Chimeras) by enabling the conjugation of CRBN with a target protein ligand through a suitable linker. Its application is significant in studies involving targeted protein degradation, offering insights into therapeutic interventions and functional protein regulation in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-629 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to specific target proteins. This compound can be employed in the design of PROTACs (PROteolysis-TArgeting Chimeras) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation makes it a valuable tool for researchers investigating novel therapeutic approaches in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-637 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling the selective degradation of specific proteins. Its use in research may aid in elucidating mechanisms of protein regulation and disease pathways. -
Ligand for E3 Ligase
CRBN ligand-386 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to adapt and selectively induce protein degradation makes it a valuable tool in chemical biology and therapeutic research, particularly in studying targeted protein degradation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-689 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the engagement of CRBN with target proteins. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking to a target protein ligand through a suitable linker. Its design is aimed at enhancing targeted protein degradation, making it a valuable tool for research in cellular signaling and therapeutic applications. -
Ligands for E3 Ligase
CRBN ligand-112 is a selective ligand for the CRBN-type E3 ubiquitin ligase, serving as a critical component in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the ubiquitination and subsequent degradation of target proteins, offering a powerful tool for investigating cellular protein turnover and modulation. Its application in research spans various fields, including cancer therapy and targeted protein degradation studies. -
Ligand for E3 Ligase
CRBN ligand-482 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein in cellular processes. It serves as a crucial component for the development of PROTACs (proteolysis-targeting chimeras) by creating a linkage between a target protein ligand and cereblon. This compound is valuable for research applications focused on targeted protein degradation and the modulation of protein levels within cells. -
Ligands for E3 Ligase
CRBN ligand-74 is a potent ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). It serves as a valuable tool in targeted protein degradation research, enabling the selective degradation of intracellular proteins. This compound is instrumental in studying various biological processes and therapeutic applications related to protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-568 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be equipped with a linker to create a PROTAC (proteolysis-targeting chimeras), enabling targeted protein degradation. CRBN ligand-568 is beneficial for studying protein regulation and ubiquitination processes in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-375 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with target-specific ligands through a linker to construct proteolysis-targeting chimeras (PROTACs). It is useful in studies aimed at modulating protein degradation pathways and investigating the role of CRBN in cellular processes. -
Ligands for E3 Ligase
CRBN ligand-16 is a ligand for the E3 ubiquitin ligase CRBN, enabling targeted protein degradation through the formation of PROTAC molecules. This compound facilitates the ubiquitination and subsequent proteasomal degradation of specific proteins, offering valuable applications in drug development and disease research. Its utility in creating bifunctional degradation agents makes it a crucial tool for studies involving protein modulation and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-427 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein to target proteins. This compound can be conjugated to a target protein ligand via a linker, enabling the formation of a PROTAC, a powerful tool for targeted protein degradation studies. Its application in protein modulation makes it valuable for various research avenues in therapeutic discovery and cellular biology. -
Ligands for E3 Ligase
CRBN ligand-84 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the ubiquitination process through targeted protein degradation. This compound is integral in the design and synthesis of PROTAC molecules, enabling the selective elimination of unwanted proteins in cellular studies. Its utility in research applications extends to investigating protein turnover and degradation pathways, supporting drug discovery efforts in targeted therapies. -
Ligand for E3 Ligase
CRBN ligand-574 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of the cereblon protein. This compound can be utilized to create PROTACs by linking it to a target protein ligand through a suitable linker. Researchers can employ CRBN ligand-574 in studies aimed at exploring targeted protein degradation pathways and therapeutic development in various disease models. -
Ligand for E3 Ligase
CRBN ligand-352 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to target protein ligands through a suitable linker, enabling the development of PROTACs (proteolysis-targeting chimeras). Its application in targeted protein degradation research provides a valuable tool for studying protein function and modulation in cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-662 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera). Its utility in targeted protein degradation research makes it a valuable tool for studying cellular protein regulation and potential therapeutic applications. -
Ligand for E3 Ligase
CRBN ligand-627 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling selective degradation of target proteins. It serves as a valuable tool in chemical biology and therapeutic research, particularly in the development of targeted protein degradation strategies. -
Ligand for E3 Ligase
CRBN ligand-440 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein within cellular systems. Its design allows for conjugation with target protein ligands through a linker, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is valuable for studying protein degradation pathways and exploring novel therapeutic strategies in targeted protein degradation research. -
Ligand for E3 Ligase
CRBN ligand-543 targets the E3 ubiquitin ligase cereblon (CRBN) and is utilized for its ability to recruit the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a Proteolysis Targeting Chimera (PROTAC), facilitating targeted protein degradation. Research applications include the investigation of protein modulation and therapeutic strategies in various diseases. -
Ligand for E3 Ligase
CRBN ligand-717 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera), thereby enabling targeted protein degradation. It is valuable in research applications focused on protein regulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-345 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). This compound is utilized to facilitate the recruitment of the CRBN protein, thereby enabling targeted protein degradation through the formation of PROTACs when linked to a target protein ligand via a suitable linker. Its application is significant in investigating the dynamics of protein turnover and elucidating cellular processes involving ubiquitination. -
Ligand for E3 Ligase
CRBN ligand-231 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to create a PROTAC (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-231 is instrumental in research applications focused on targeted protein degradation and the study of ubiquitin-proteasome pathway mechanisms. -
Ligand for E3 Ligase
CRBN ligand-461 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). It facilitates the recruitment of the CRBN protein and can be utilized to form a PROTAC by linking to a target protein ligand through a suitable linker. This compound is instrumental in studies involving targeted protein degradation and has potential applications in drug discovery and development. -
Ligand for E3 Ligase
CRBN ligand-303 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. Its ability to be conjugated with a target protein ligand through a linker allows for the development of PROTACs, enabling targeted protein degradation. This compound is instrumental in studying protein regulation and exploring therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-563 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it with target protein ligands via a suitable linker. Its applications include targeted protein degradation studies and exploring novel therapeutic strategies in various diseases. -
Ligand for E3 Ligase
CRBN ligand-587 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, allowing for the targeted degradation of these proteins through the PROTAC (Proteolysis Targeting Chimeras) pathway. CRBN ligand-587 is instrumental in research applications focusing on protein modulation and targeted protein degradation strategies. -
Ligand for E3 Ligase
CRBN ligand-201 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to link with target protein ligands through a suitable linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application is primarily in the fields of targeted protein degradation and drug discovery, offering insights into cellular regulation and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-635 is an E3 ubiquitin ligase ligand specifically designed to interact with cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling targeted protein degradation by forming a PROTAC when conjugated with a target protein ligand through a linker. The biological activity of CRBN ligand-635 makes it valuable for research applications focused on protein homeostasis and novel therapeutic strategies in cellular and molecular biology. -
Ligand for E3 Ligase
CRBN ligand-713 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-713 serves as a valuable tool in chemical biology for studying protein regulation and potential therapeutic applications in targeted degradation strategies. -
Ligand for E3 Ligase
CRBN ligand-373 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein to target proteins. This compound is designed to be covalently linked to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation research offers valuable insights into cellular processes and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-633 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of proteolysis-targeting chimeras (PROTACs) when linked to specific target protein ligands through a suitable linker. This compound is instrumental in modulating protein degradation pathways for research in drug development and targeted cancer therapies. -
Ligand for E3 Ligase
CRBN ligand-580 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimeras), enabling targeted protein degradation. Its applications include insights into protein regulation mechanisms and drug discovery processes. -
Ligand for E3 Ligase
CRBN ligand-296 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through PROTAC (Proteolysis Targeting Chimeras) technology. This compound is valuable for research applications focused on ubiquitin-mediated proteolysis and the development of novel therapeutic strategies for various diseases. -
Ligand for E3 Ligase
CRBN ligand-393 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. It can be effectively linked to target protein ligands through a suitable linker to create a PROTAC, enabling targeted protein degradation. This compound is valuable for research applications focused on therapeutic interventions in cellular processes mediated by protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-555 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the synthesis of a PROTAC (proteolysis-targeting chimera). CRBN ligand-555 serves as a valuable tool in studies of targeted protein degradation and has applications in the development of novel therapeutic strategies for various diseases. -
Ligands for E3 Ligase
(S,S,S)-AHPC-Me is a ligand for E3 ligases, playing a crucial role in targeted protein degradation pathways. This compound facilitates the synthesis of PROTACs, specifically the (4S)-PROTAC SOS1 degrader-1 diTFA. Its efficacy in modulating E3 ligase activity makes it valuable for research applications in cellular signaling and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-528 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It serves as a molecular tool to recruit the CRBN protein, facilitating targeted protein degradation when conjugated to a target protein ligand through a suitable linker. This compound is essential for research applications focused on understanding ubiquitin-mediated proteolysis and developing PROTAC (Proteolysis Targeting Chimera) strategies for therapeutic intervention. -
Ligand for E3 Ligase
CRBN ligand-413 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein and can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. Its applications are significant in studying targeted protein degradation and the modulation of protein levels within cellular contexts. -
Ligand for E3 Ligase
CRBN ligand-264 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling targeted recruitment of the CRBN protein. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker, facilitating selective degradation of proteins in cellular environments. Its application in research may enhance studies related to protein regulation and therapeutic interventions targeting protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-271 is a targeted ligand for the E3 ubiquitin ligase cereblon (CRBN). It functions by recruiting the cereblon protein, enabling the formation of PROTACs (proteolysis-targeting chimeras) when linked to a specific target protein ligand through a suitable linker. This compound is valuable for studies involving targeted protein degradation and cellular regulation, assisting researchers in exploring novel therapeutic approaches in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-659 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a suitable linker, enabling the development of PROTACs (proteolysis-targeting chimeras). Its utility in research lies in targeted protein degradation and the modulation of cellular pathways, making it a valuable tool for studying protein function and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-634 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, making it a vital component in the design of proteolysis-targeting chimeras (PROTACs). This reagent is suitable for studies aimed at investigating targeted protein degradation and its therapeutic potential in various diseases. -
Ligand for E3 Ligase
CRBN ligand-234 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-234 serves as a valuable tool in studies of targeted protein degradation and the therapeutic potential of PROTACs in various biological contexts.
