Catalog No.
Product Name
Application
Product Information
Citations
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Ligands for E3 Ligase
Pomalidomide-C11-NH2 is a Pomalidomide derivative that functions as a ligand for the E3 ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN protein, enabling targeted protein degradation applications through PROTAC technology. Its utility in the development of targeted therapeutics offers significant potential for advancing cancer research and treatment strategies. -
CRBN Ligand
Pomalidomide-5-C5-NH2 hydrochloride is a cereblon (CRBN) ligand derived from Pomalidomide, designed to facilitate the recruitment of the CRBN protein. This compound serves as a crucial component for the development of PROTACs that promote targeted protein degradation. Its unique structural modifications enhance its ability to engage with CRBN, enabling innovative research into therapeutic applications in cancer and other diseases. -
CRBN Degrader-Linker Conjugate
CDLI-5 is a cereblon (CRBN) degrader-linker conjugate designed for the synthesis of cereblon degrader antibody conjugates (cDACs). This compound enables targeted protein degradation through the recruitment of E3 ligases to specific substrates, facilitating effective modulation of protein levels. CDLI-5 serves as a valuable tool in research applications focused on targeted therapies and the development of novel anticancer strategies. -
Ligands for E3 Ligase
VH032-C2-NH-Boc is a Boc-modified ligand targeting the von Hippel-Lindau (VHL) E3 ligase, facilitating the recruitment of VHL proteins. Upon exposure to acidic conditions, it readily removes the protecting group, enabling its application in the direct synthesis of PROTAC molecules. This compound serves as an essential intermediate in developing PROTACs that utilize VHL ligands, offering valuable utility in targeted protein degradation research. -
BRD4 PROTAC
Lenalidomide-CO-C7-NH2 is a CRBN-dependent intermediate designed as a BRD4-targeting PROTAC degrader. This compound facilitates the selective degradation of the oncoprotein BRD4, leading to decreased cancer cell proliferation, cell cycle arrest, and enhanced apoptosis. It demonstrates noteworthy anti-tumor efficacy in xenograft models, making Lenalidomide-CO-C7-NH2 a valuable tool for investigating mechanisms in acute myeloid leukemia research. -
Ligands for E3 Ligase
VH032-C3-Boc is a Boc-modified derivative of VH032, functioning as a ligand for the E3 ligase von Hippel-Lindau (VHL). Under acidic conditions, VH032-C3-Boc enables the removal of the protective group, facilitating direct utilization in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as an essential intermediate for developing VHL-based PROTACs, contributing to advancements in targeted protein degradation research. -
Ligands for E3 Ligase
β-Naphthoflavone-CH2-OH is a selective ligand for the arylhydrocarbon receptor (AhR) E3 ligase. This compound serves as a critical component in the design of targeted protein degradation strategies, such as PROTACs and SNIPERs, by linking to specific protein ligands to facilitate the recruitment of the AhR E3 ligase complex. Its ability to induce ubiquitination-mediated degradation of oncoproteins makes it a valuable tool in cancer research and drug discovery. -
E3 Ligase Ligand-Linker Conjugate
CRBN ligand-8-O-C6-NH2 is an E3 ligase ligand-linker conjugate that targets the cereblon (CRBN) E3 ubiquitin ligase, facilitating targeted protein degradation. This compound serves as a critical component in the synthesis of PROTAC ERα Degrader-11, thus aiding in the study of estrogen receptor-alpha (ERα) modulation and its associated cellular pathways. Researchers can utilize CRBN ligand-8-O-C6-NH2 for advancing the development of targeted therapeutic strategies in cancer and other diseases influenced by ERα signaling. -
Ligands for E3 Ligase
VH 032 amide-PEG6-amine hydrochloride is a functionalized ligand for the von Hippel-Lindau (VHL) E3 ligase, specifically designed for PROTAC (Proteolysis Targeting Chimera) development. This compound features an E3 ligase ligand conjugated to a PEG6 moiety, facilitating the incorporation of terminal amines for coupling with target protein ligands. VH 032 amide-PEG6-amine hydrochloride is essential for advancing research in targeted protein degradation and drug development strategies. -
Ligands for E3 Ligase
VH032-C4-NH-Boc is a Boc-modified variant of the VH032 compound that serves as a ligand for the von Hippel-Lindau (VHL) protein, facilitating the recruitment of VHL in E3 ligase applications. Upon exposure to acidic conditions, the Boc protecting group is removed, enabling its use in the synthesis of PROTAC molecules. This compound is a critical intermediate for developing PROTAC strategies that leverage VHL ligands for targeted protein degradation research. -
Ligands for E3 Ligase
VH032-PEG2-NH-BOC is a Boc-modified VH032 compound that functions as a ligand for E3 ligase von Hippel-Lindau (VHL). This reagent facilitates the recruitment of VHL proteins and can be deprotected under acidic conditions, enabling its direct application in PROTAC molecule synthesis. VH032-PEG2-NH-BOC serves as a crucial intermediate for generating PROTACs utilizing VHL ligands, thereby advancing research in targeted protein degradation and therapeutic applications. -
E3 Ligand-Linker Conjugate
CRBN Ligand-Linker Conjugate 2 is an E3 ligand-linker conjugate designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted degradation of specific proteins by harnessing the ubiquitin-proteasome system. It has been utilized in the development of FIP22, a highly selective IRAK4 PROTAC degrader, which demonstrates potential therapeutic activity against atopic dermatitis. Researchers can leverage this conjugate for advancements in targeted protein degradation strategies. -
Ligands for E3 Ligase
VH032-O-C2-NH-Boc is a Boc-modified derivative of VH032, functioning as a ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL). This compound facilitates the recruitment of VHL proteins and is valuable in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. The Boc protective group can be removed under acidic conditions, allowing for efficient integration into PROTAC development and research applications focused on targeted protein degradation. -
lenalidomide-derived azide
Lenalidomide 4'-PEG1-azide is a lenalidomide-derived azide designed for use in click chemistry applications. This compound features an azide moiety that engages in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, facilitating efficient bioconjugation. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing partners, making it valuable for various chemical biology studies and the development of novel therapeutics. -
Ligands for E3 Ligase
Lenalidomide 4'-PEG2-azide is a Lenalidomide-derived ligand that targets Cereblon, facilitating the recruitment of CRBN protein. This compound can be utilized to create PROTACs by linking it to various proteins, thereby enabling targeted protein degradation and advancing research in drug development and cellular regulation. Its use is relevant in the study of E3 ligase-mediated pathways and therapeutic strategies in oncology and immunology. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-NH-C4-Boc is a conjugate that targets the E3 ligase Cereblon through an innovative linker. This compound facilitates the synthesis of PROTAC CARM1/IKZF3 degrader-1, enabling targeted protein degradation studies. Its primary application lies in the development of novel therapeutics and novel molecular probes in cellular research. -
E3 Ubiquitin Ligase Ligands and Linkers for PROTACs
6-Aminocaproic acid-(S,R,S)-AHPC-Me is a ligand and linker designed for E3 ubiquitin ligase in proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the development of targeted protein degradation approaches, making it valuable in tumor research and related applications. Its utilization in synthesizing PVD-06 highlights its importance in advancing therapeutic strategies against cancer. -
Ligands for E3 Ligase
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized ligand targeting the von-Hippel-Lindau (VHL) protein, facilitating the development of PROTACs. This compound promotes selective protein degradation by engaging E3 ligases, making it a valuable tool for studying protein turnover and cellular regulation. Its application in chemical biology can aid in understanding the mechanisms of targeted protein degradation and potential therapeutic interventions. -
PROTAC Linker
Ms-PEG8-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a Boc-protected amine that facilitates conjugation to target proteins, enhancing the efficient recruitment of E3 ligases. Ms-PEG8-Boc plays a critical role in research applications focused on targeted protein degradation, enabling the study of protein function and therapeutic development in various disease models. -
PROTAC Linkers
m-PEG2-Amino is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies by providing a flexible and hydrophilic backbone. Its application in the construction of PROTACs enables researchers to enhance the selectivity and efficacy of targeted therapies. -
PROTAC Linker
Succinamic acid functions primarily as a linker in the construction of PROTAC molecules. This compound has been characterized as a weak inhibitor of human LL-xylose reductase, exhibiting an IC50 value of 1.45 mM. Its structural properties make it instrumental in synthesizing compounds such as CQ-16, facilitating advancements in targeted protein degradation research. -
PROTAC Linker
Azido-PEG9-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, facilitating the conjugation of alkyne- or DBCO/BCN-containing molecules, respectively. Its versatility makes Azido-PEG9-Boc a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linkers
(+)-Biotin-PEG2-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent degradation. Its application is critical in the development of novel therapeutic strategies for various diseases, particularly in the field of targeted protein degradation research. -
PROTAC linker
N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a PEG-based linker designed for PROTAC synthesis. It features an azide functional group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds. This versatile linker is valuable for optimizing PROTAC constructs in chemical biology research. -
PROTAC Linker
Boc-NHCH2-Ph-pyrimidine-NH2 serves as a versatile linker for PROTAC (Proteolysis Targeting Chimeras) applications. By facilitating the conjugation of target proteins with E3 ligases, this compound enhances the selective degradation of proteins of interest. Its unique structure allows for improved target engagement and therapeutic potency, making it an essential tool for drug discovery and chemical biology research focused on targeted protein degradation. -
PROTAC Linker
N-Boc-N-bis(PEG3-azide) is a PEG-based PROTAC linker that facilitates the synthesis of targeted protein degraders. This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for researchers in the field of protein degradation and chemical biology. -
PROTAC Linkers
N-Me-N-bis-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby enhancing the targeted degradation of specific proteins in cellular studies. Its application is crucial in the development of innovative therapeutics that modulate protein levels to investigate biological pathways and disease mechanisms. -
PROTAC linker
Boc-N-Amido-PEG5-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ligases, enhancing targeted therapeutic strategies in chemical biology. Its application extends to various fields including drug discovery and the development of novel therapeutic agents aimed at specific molecular targets. -
PROTAC Linkers
Propargyl-PEG11-methane serves as a versatile PEG-based linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC design makes it a valuable reagent for targeted protein degradation studies and drug discovery research. -
PROTAC Linker
m-PEG4-propargyl is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. Featuring an alkyne group, this compound serves as a click chemistry reagent, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is instrumental in the development of targeted protein degradation strategies and can be utilized in various research applications focusing on protein modulation and therapeutic discovery. -
PROTAC Linker
N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the development of PROTAC (proteolysis-targeting chimeras) applications. This compound facilitates the conjugation of ligand-recruiting components to E3 ligase adapters, enabling targeted protein degradation mechanisms. Its flexible PEG structure enhances solubility and biocompatibility, making it suitable for various biochemical and pharmacological investigations in drug discovery and development. -
PROTAC Linker
Boc-Aminooxy-PEG1-C2-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of proteins within cellular systems. It is an essential tool for researchers investigating targeted protein modulation and ubiquitin-proteasome system dynamics. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the development of targeted protein degradation strategies by linking proteins of interest to E3 ligases, enhancing their ubiquitination and subsequent degradation. Its unique trifluoroethyl moiety provides distinct chemical properties that may improve solubility and linker stability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linkers
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based linker designed for the synthesis of PROTACs. This reagent features a DBCO group that allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its biotin component enhances labeling and purification processes, making it valuable in target protein degradation studies and other biochemical applications. -
PROTAC Linkers
Boc-NH-PEG10-CH2CH2COOH is a polyethylene glycol (PEG)-derived linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and pharmacokinetic properties of PROTACs, promoting efficient protein degradation and targeted therapeutic efficacy. Its carboxylic acid functionality facilitates conjugation to target ligands, making it a valuable tool in chemical biology and drug discovery research focused on novel therapeutics. -
PROTAC Linkers
Benzyl-PEG24-MS is a PEG-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the precise conjugation of target protein ligands and ubiquitin E3 ligase binding domains, enhancing the design of bifunctional molecules for targeted protein degradation. Its unique structure allows for increased solubility and improved biocompatibility, making it suitable for various applications in the study of targeted therapies and protein modulation. -
PROTAC Linkers
Amino-PEG23-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligand and E3 ligase components, enhancing the selective degradation of target proteins. Its unique structural properties make it suitable for various applications in target protein modulation and therapeutic development. -
PROTAC Linkers
TCO-PEG6-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This intermediary compound facilitates the conjugation of targeting ligands to E3 ligases, thereby enhancing the efficiency of targeted protein degradation. Its versatile applications in drug discovery make it a valuable tool for researchers investigating protein modulation and degradation pathways. -
PROTAC Linkers
6-Maleimidocaproic acid-PFP ester is a versatile PROTAC linker that features an alkyl chain structure. It facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs) by enabling the conjugation of target proteins to E3 ligases. This reagent is essential for applications in targeted protein degradation studies and can enhance the development of novel therapeutics in cancer research and other diseases. -
PROTAC Linker
3-Hydroxyazetidine-Cyclohexanol serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its chemical structure is designed to enhance the efficacy of targeted protein degradation, making it a valuable tool in drug discovery and development research. This compound is instrumental in the synthesis of ALK PROTACs, contributing to advancements in targeted therapies for various cancers. -
PROTAC Linker
Benzyl-PEG8-THP is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound promotes the targeted degradation of specific proteins through an E3 ubiquitin ligase-mediated pathway. Its application is essential in drug discovery and development for creating novel therapeutics that modulate protein levels in a highly selective manner. -
PROTAC Linker
Ald-Ph-amido-C2-PEG3-NH-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of targeted protein degradation systems by connecting target proteins to E3 ligases. It enhances selectivity and efficiency in protein degradation studies, making it a valuable tool for research in targeted therapeutics and cellular pathways. -
PROTAC linker
Hydroxy-Amino-bis(PEG2-propargyl) serves as a PEG-based PROTAC linker, facilitating the design of proteolysis-targeting chimeras (PROTACs). This versatile compound features an alkyne moiety, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application in research supports the development of targeted protein degradation strategies, enhancing the exploration of protein functions and therapeutic interventions. -
PROTAC Linkers
Thiol-C9-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of selected proteins within cellular systems. This compound is essential for researchers exploring targeted protein degradation and related therapeutic modalities in various biological contexts. -
PROTAC Linkers
CHO-CH2-PEG1-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the development of bifunctional molecules that promote targeted degradation of specific proteins, enabling innovative therapeutic strategies. Its hydrophilic nature enhances solubility, making it suitable for various biological applications in chemical biology and medicinal chemistry research. -
PROTAC Linker
Azide-PEG7-Tos is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its versatility in click chemistry expands the potential for targeted protein degradation studies, making it an essential tool for researchers in areas such as drug discovery and targeted therapy development. -
PROTAC Linkers
Bromo-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase recruiting components, enhancing the efficacy of targeted protein degradation. Its versatile chemical properties make it suitable for various applications in chemical biology research, particularly in the development of novel therapeutics focusing on selective protein modulation. -
PROTAC Linkers
Hydroxy-PEG12-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, thereby promoting targeted degradation pathways. Hydroxy-PEG12-Boc enhances cellular permeability and solubility of PROTACs, making it essential for studies in targeted protein degradation and cellular biotechnology research. -
PROTAC Linker
Azido-PEG3-phosphonic acid ethyl ester is a PEG-based linker designed for PROTAC synthesis, targeting the ubiquitin-proteasome system to facilitate protein degradation. This compound features an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that possess DBCO or BCN groups, making it a valuable tool for developing targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Azido-PEG8-C1-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds. Its versatility in click chemistry makes it an invaluable tool for researchers focused on targeted protein degradation and biochemical studies.
