Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
3,4-Dibromo-Mal-PEG8-Boc is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a dibromomalonate moiety that facilitates the formation of covalent bonds with target proteins, enabling targeted degradation. Its solubility properties and flexibility make it a valuable tool in the development of advanced therapeutic agents aimed at modulating protein levels in cellular research applications. -
PROTAC Linkers
Fmoc-NMe-PEG4-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, promoting targeted degradation pathways in live cells. Its unique structure allows for improved solubility and stability, making it ideal for various research applications in drug discovery and development, particularly for studies on protein homeostasis and targeted therapies. -
PROTAC Linkers
DBCO-NHCO-PEG2-Biotin is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a DBCO (dibenzylcyclooctyne) group that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its biotin component enhances the attachment of PROTACs to target proteins, facilitating studies on targeted protein degradation and cellular dynamics. DBCO-NHCO-PEG2-Biotin is essential for research applications involving targeted therapeutic strategies and the exploration of protein interactions. -
PROTAC Linkers
Azido-PEG6-C2-Boc is a PEG-based linker designed for the synthesis of PROTACs, functioning primarily through click chemistry mechanisms. This compound features an azide functional group that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN moieties. Azido-PEG6-C2-Boc is instrumental in the development of targeted protein degradation strategies in chemical biology and therapeutic research. -
PROTAC Linker
Fluorescein-PEG4-acid is a PEG-based linker designed for use in proteolysis-targeting chimeras (PROTACs). This compound facilitates the synthesis of PROTACs by providing properties that enhance cellular retention and targeting efficiency. Its fluorescent characteristics also support applications in imaging studies and monitoring cellular localization of the PROTACs in various biological contexts. -
PROTAC Linkers
m-PEG5-triethoxysilane is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted degradation pathways. Its primary application lies in developing novel therapeutic agents by enabling selective modulation of protein levels in various biological contexts. -
PROTAC Linker
Ethyl acetate-PEG1 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of stable and effective PROTACs, enabling targeted protein degradation in therapeutic applications. Its unique structure enhances solubility and flexibility, making it suitable for a variety of biological research settings focused on protein modulation and regulation. -
PROTAC Linkers
S-acetyl-PEG4-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This reagent enhances the solubility and stability of PROTACs, facilitating target protein degradation. Its application is critical in drug discovery and development, particularly in the field of targeted protein modulation for therapeutic interventions. -
PROTAC linker
Azido-PEG3-O-NHS ester serves as a versatile PEG-based linker for the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide functional group, facilitating efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, interacting with DBCO or BCN functionalized substrates, making it essential for applications in chemical biology and targeted protein degradation research. -
PROTAC Linker
m-PEG6-Tos is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the synthesis of PROTACs. This linker enhances solubility and improves pharmacokinetic properties, making it suitable for targeted protein degradation applications. It is commonly utilized in research focused on therapeutic protein modulation and drug discovery. -
PROTAC Linkers
Bromoacetamide-PEG3-propargyl is a PEG-based linker designed for use in the synthesis of PROTeolysis TArgeting Chimeras (PROTACs). This compound features an alkyne functional group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Bromoacetamide-PEG3-propargyl serves as a valuable component in the development of targeted protein degradation strategies, facilitating the construction of effective chimeric molecules for research in cellular biology and therapeutic development. -
PROTAC Linker
Bromo-PEG5-C2-acid is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (proteolysis targeting chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. Its application in the development of PROTACs makes it a valuable tool for researchers investigating protein regulation, degradation pathways, and the therapeutic potential of targeted protein modulation. -
PROTAC Linkers
Mal-PEG4-Boc is a bifunctional PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of ligands to E3 ligases, enabling targeted protein degradation in various cellular contexts. Its application extends to chemical biology research, enabling the study of protein function and the development of novel therapeutic strategies. -
PROTAC Linker
Hydroxy-PEG3-NHS is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands to E3 ubiquitin ligases, enabling the selective degradation of specific proteins. Hydroxy-PEG3-NHS is ideal for studies focused on targeted protein degradation, and it plays a crucial role in expanding the toolbox for drug development in therapeutic research. -
PROTAC Linker
Azide-PEG2-MS is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. Featuring an azide group, it is a versatile click chemistry reagent that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, Azide-PEG2-MS can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing molecules, facilitating the development of innovative protein-targeting therapies. This linker is ideal for researchers investigating protein degradation and its therapeutic potential. -
PROTAC Linkers
Azido-PEG4-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) through click chemistry. Featuring an azide group, it readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized molecules. This versatility makes Azido-PEG4-Boc an essential reagent for constructing targeted protein degradation strategies in chemical biology research. -
PROTAC linker
1,3-Bis-aminooxy propane dihydrochloride serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structural properties enhance the ability to selectively degrade target proteins through the ubiquitin-proteasome pathway. This compound is instrumental in chemical biology research for developing targeted protein degradation strategies. -
PROTAC Linker
Acid-PEG1-C2-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTACs, which are innovative therapeutics for targeted protein degradation. This compound features a carboxylic acid group that enhances solubility and provides a site for conjugation with targeting ligands. Its utility in PROTAC development supports research in drug discovery and the exploration of novel therapeutic interventions. -
PROTAC Linker
Tos-PEG4-acid is a PEG-based PROTAC linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC constructs, thereby improving their efficacy in targeted protein degradation research. It is an essential tool for studies aimed at exploring novel therapeutic strategies in oncology and other diseases. -
PROTAC Linker
m-PEG4-aldehyde is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the efficient conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation of the target protein. Its application in drug discovery and development makes it a valuable tool for researchers investigating targeted protein degradation strategies. -
PROTAC Linkers
Bis-PEG11-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs by providing a flexible and hydrophilic spacer that enhances solubility and stability. Its applications extend to targeted protein degradation studies and the development of novel therapeutic agents in chemical biology research. -
PROTAC Linker
Propargyl-PEG4-Boc is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing partners. Its application is pivotal in the development of targeted protein degradation strategies, facilitating the creation of bifunctional molecules for modulating protein levels in cellular studies. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. This compound is instrumental in the development of innovative research tools aimed at targeted protein degradation, enabling studies in cellular biology and therapeutic development. -
PROTAC Linkers
DBCO-PEG9-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring a DBCO moiety, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound enables precise and efficient conjugation strategies, making it valuable for applications in targeted protein degradation research. -
PROTAC Linker
m-PEG3-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. This linker enhances the solubility and pharmacokinetic properties of PROTAC molecules, making it valuable in drug discovery and development within the context of targeted therapies. -
PROTAC Linkers
HO-PEG20-OH is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. Its unique structure enhances solubility and flexibility, making it suitable for various biochemical applications in drug discovery and development. -
PROTAC Linkers
Propargyl-PEG3-methane is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an alkyne functional group, this compound facilitates the copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction, enabling efficient conjugation with azide-containing molecules. It is a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linker
Benzyl-PEG4-acid is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras. This compound enhances the solubility and stability of PROTACs, enabling effective targeting and degradation of specific proteins within cellular environments. It is primarily utilized in research applications involving targeted protein degradation and the exploration of protein interactions. -
PROTAC Linkers
TCO-PEG3-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase, promoting ubiquitination and subsequent degradation. Its versatile structure makes it a valuable tool in chemical biology for the development of targeted protein degradation strategies. -
PROTAC Linker
NH-bis(PEG3-Boc) is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. It enables efficient conjugation of target proteins and E3 ligases, facilitating selective degradation of unwanted proteins. This compound is particularly valuable in chemical biology and drug discovery research focusing on targeted protein degradation mechanisms. -
PROTAC Linkers
Propargyl-PEG2-beta-D-glucose is a PEG-based linker designed specifically for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs by providing a suitable chemical scaffold for target protein degradation studies. Its unique structure enhances the versatility and efficacy of PROTACs in biochemical research, enabling targeted therapeutic approaches in fields such as oncology and drug discovery. -
PROTAC Linkers
Azido-PEG9-S-methyl ethanethioate is a PEG-based linker designed for the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for chemical biology applications in targeted protein degradation research. -
PROTAC Linker
Tri-(PEG1-C2-acid) functions as a PEG-based PROTAC linker, facilitating the synthesis of PROTAC molecules for targeted protein degradation. This compound enhances solubility and biocompatibility, making it an essential component in drug development and chemical biology research focusing on ubiquitin-proteasome pathways. Its utility in constructing effective PROTACs can aid in studies aimed at modulating protein levels in various biological systems. -
PROTAC Linker
Boc-NH-PEG10-CH2CH2NH2 is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structure facilitates the effective conjugation of ligands and E3 ligase recruiters, enabling targeted protein degradation. This compound is instrumental in advancing research related to targeted therapies and compound development in cellular and molecular biology. -
PROTAC Linker
m-PEG2-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the development of PROTACs by providing a flexible and hydrophilic moiety that can enhance their solubility and bioavailability. Its application in chemical biology allows for targeted protein degradation studies, making it a valuable tool in drug discovery and therapeutic research. -
PROTAC Linkers
m-PEG7-4-nitrophenyl carbonate is a PEG-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates the conjugation of protein ligands to E3 ligase recruiters, enabling targeted protein degradation. It is ideal for applications in drug discovery and development, particularly in the study of protein modulation and the regulation of cellular pathways. -
PROTAC Linker
OTs-C6-OBn is an alkyl chain-based PROTAC linker designed for the synthesis of PROTAC conjugates targeting the SGK3 protein. This compound facilitates targeted protein degradation by linking E3 ligases to specific protein substrates, thereby enhancing the efficacy of PROTACs in biological research. It is suitable for applications in drug development and proteostasis modulation studies. -
PROTAC Linkers
DBCO-PEG6-amine is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This versatile reagent facilitates the construction of bifunctional molecules for targeted protein degradation studies, enhancing research in cellular regulation and therapeutic development. -
PROTAC Linkers
HO-PEG18-OH is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTACs by providing a flexible and biocompatible linker that enhances the efficiency of targeted protein degradation. Its key biological activity involves improving the solubility and stability of PROTAC constructs, making it valuable for research in targeted therapeutics. -
PROTAC Linkers
PEG8-Tos is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of high-performance PROTACs by enhancing solubility and stability, which are critical for effective protein degradation. Its use is essential in biochemical research focusing on targeted protein modulation and degradation studies, making it a valuable tool for drug discovery and development. -
PROTAC Linkers
Amino-PEG9-amine is a polyethylene glycol (PEG)-based linker designed for the development of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the conjugation of targeting moieties to E3 ligase ligands, enhancing the specificity and efficacy of PROTACs in targeting proteins for ubiquitination and subsequent degradation. Its applications are pivotal in the study of targeted protein degradation and the modulation of cellular pathways in various research fields, including cancer biology and drug discovery. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. This compound features an azide moiety that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzoazacyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating the development of versatile bioconjugates in chemical biology research. -
PROTAC Linker
NH2-PEG2-methyl acetate hydrochloride is a polyethylene glycol-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of targeting ligands to E3 ubiquitin ligases, enabling the selective degradation of specific proteins in cellular systems. Its unique chemical structure enhances solubility and flexibility, making it a valuable tool for researchers investigating protein regulation and degradation pathways. -
PROTAC Linker
Bromoacetamido-PEG3-NH-Boc is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted degradation pathways. Its applications are essential in chemical biology and drug discovery, allowing for the development of innovative therapeutic strategies through selective protein modulation. -
PROTAC Linkers
Mal-PEG6-mal is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficacy of PROTACs by facilitating the coupling of target proteins with E3 ligases to promote targeted degradation. Its applications span the development of novel therapeutics aimed at addressing difficult-to-treat diseases through targeted protein modulation. Mal-PEG6-mal is essential for researchers investigating innovative approaches in protein degradation technologies. -
PROTAC Linker
Methyltetrazine-PEG5-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. It is suitable for applications in drug discovery and development, enabling researchers to investigate protein function and therapeutic potential in various biological contexts. -
PROTAC Linkers
(+) -Biotin-ONP is a biotinylated linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeting and degradation of proteins through the recruitment of E3 ligases, thereby enhancing the effectiveness of protein modulation studies. It is an essential tool for researchers exploring targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC Linkers
Bromoacetamido-PEG5-DOTA is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bromacetamido moiety that facilitates covalent bonding with target proteins, thereby enhancing the efficacy of targeted protein degradation. Bromoacetamido-PEG5-DOTA is instrumental in the development of novel therapeutic strategies in oncology and other fields by allowing precise modulation of protein levels within cells. -
PROTAC Linkers
Boc-Aminoxy-PEG4-OH is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC molecules, facilitating the development of targeted protein degradation strategies. It is invaluable in research applications focusing on the design and optimization of PROTACs for therapeutic purposes. -
PROTAC Linkers
DBCO-PEG1-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring a DBCO moiety, this compound facilitates efficient click chemistry through strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing substrates. DBCO-PEG1-acid is integral for developing targeted degradation strategies in protein research, enabling precise modulation of protein levels for various biological applications.
