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VH032-O-C2-NH-Boc

Ligands for E3 Ligase

VH032-O-C2-NH-Boc is a Boc-modified derivative of VH032, functioning as a ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL). This compound facilitates the recruitment of VHL proteins and is valuable in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. The Boc protective group can be removed under acidic conditions, allowing for efficient integration into PROTAC development and research applications focused on targeted protein degradation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2409007-41-4
Applications	Ligands for E3 Ligase
Formula	C₃₁H₄₅N₅O₇S
Molecular Weight	631.78
SMILES	O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCNC(OC(C)(C)C)=O)=O)=O)C[C@H](O)C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.