Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
1,4-Diisocyanatobutane is a versatile PROTAC linker that facilitates the development of proteolysis targeting chimeras (PROTACs). Its unique structure enables efficient conjugation to both ligand and E3 ligase moieties, enhancing targeted protein degradation. This compound is essential for researchers focusing on targeted therapy and drug development in the fields of cancer research and other diseases. -
PROTAC Linker
Benzyl 4-hydroxybutanoate is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the selective degradation of target proteins by promoting the formation of ternary complexes between E3 ligases and substrate proteins. Its application is significant in the field of drug discovery, particularly in the development of innovative therapeutics for various diseases by harnessing the cellular ubiquitin-proteasome system. -
PROTAC Linker
4-Piperidineacetic acid hydrochloride serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. This compound is instrumental in the synthesis of custom PROTACs, enabling researchers to probe biological pathways and investigate protein function with enhanced specificity. Its versatile structure supports various applications in drug discovery and therapeutic development, particularly in the field of targeted therapies. -
PROTAC Linker
Rel-(1R,4R)-4-Aminocyclohexane-1-carbonitrile hydrochloride serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial in connecting targeting and E3 ligase components, thereby promoting ubiquitination and degradation of specific proteins. Its application in research enhances the study of protein modulation and targeted therapy strategies. -
PROTAC Linker
Cl-C6-PEG3-C3-acid is a PROTAC linker designed for the efficient synthesis of PROTAC molecules. This compound facilitates the formation of targeted protein degradation approaches by connecting E3 ligases with target proteins. Its structure enhances solubility and flexibility, making it optimal for use in drug discovery and development aimed at manipulating intracellular protein levels. -
PROTAC Linker
tert-Butyl 5-iodopentanoate is a PROTAC linker designed to facilitate the construction of Proteolysis Targeting Chimeras (PROTACs). This compound enables the selective degradation of target proteins by linking E3 ubiquitin ligases to specific ligands, promoting targeted protein elimination. It serves as a crucial component in the development of therapeutic agents aimed at modulating protein levels in various research applications, including cancer and other diseases. -
PROTAC Linker
N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5 is a PEG-based PROTAC linker designed for synthesizing proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs by linking target proteins to E3 ligases, thereby promoting targeted degradation. Its unique structure allows for effective conjugation with various biomolecules, enabling advanced research into protein regulation and targeted therapeutics. -
PROTAC Linker
Propane-1,3-diyl bis(4-methylbenzenesulfonate) is a specialized PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enables the formation of a stable connection between a target protein and an E3 ligase, promoting targeted degradation via the ubiquitin-proteasome pathway. It is valuable in biochemical research for developing therapeutic strategies that modulate protein levels and functions. -
PROTAC Linker
tert-Butyl (2-(2-bromoethoxy)ethyl)(methyl)carbamate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound serves as a critical component in the synthesis of PROTACs, enabling targeted protein degradation. It allows researchers to explore novel therapeutic strategies by selectively eliminating specific proteins within cellular contexts. -
PROTAC Linker
tert-Butyl (4-aminobicyclo[2.2.2]octan-1-yl)carbamate serves as a valuable PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in enhancing the degradation of specific proteins, allowing for targeted therapeutic interventions in various biological pathways. Its application in research includes the synthesis of PROTACs for studying protein dynamics and therapeutic efficacy. -
PROTAC Linker
5-Hydroxypentanenitrile serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the development of targeted protein degradation strategies, enhancing the degradation of specific proteins within cellular systems. Its application is vital in various areas of drug discovery and therapeutic development, particularly in targeting disease-relevant proteins for selective degradation. -
PROTAC Linker
1,8-Diiodooctane is a PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). By providing a stable connection between an E3 ligase ligand and a target protein ligand, this compound enhances the selective degradation of specific proteins in cellular assays. It is particularly useful in the development of targeted protein degradation strategies in biochemical and pharmacological research. -
PROTAC Linker
Trans-4-(Aminomethyl)cyclohexanemethanol is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the synthesis of PROTACs by connecting target proteins to E3 ligases, thus promoting targeted protein degradation. It is valuable for researchers investigating selective protein modulation and degradation pathways. -
PROTAC Linker
Di-tert-butyl succinate is a PROTAC linker utilized in the development of proteolysis targeting chimeras (PROTACs). This compound enables the efficient synthesis of PROTACs by facilitating the conjugation of target ligands to E3 ligase ligands. Its application enhances the selective degradation of target proteins, making it valuable for chemical biology studies and therapeutic development. -
PROTAC Linker
3,3'-Thiodipropanoic acid is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the efficient conjugation of target proteins to E3 ligases, thereby promoting targeted protein degradation. Its unique structure enhances the stability and efficacy of PROTACs, making it valuable in drug development and pharmacological research aimed at modulating protein levels in various biological systems. -
PROTAC Linker
HO-PEG14-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of proteins or small molecules to enhance targeted protein degradation pathways. Its unique structure allows for increased solubility and flexibility, making it suitable for a variety of cellular and molecular biology applications, particularly in drug discovery and therapeutic development. -
PROTAC Linkers
Bis-aminooxy-PEG2 is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. This compound facilitates the formation of PROTACs, enabling targeted protein degradation. Its unique structure enhances solubility and provides flexibility, making it valuable for exploring novel therapeutic strategies in the field of targeted protein degradation research. -
PROTAC Linkers
t-Boc-Aminooxy-PEG5-azide is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This linker is valuable for researchers developing targeted protein degradation strategies in chemical biology and therapeutic applications. -
PROTAC Linker
N-Mal-N-bis(PEG2-acid) is a PEG-derived PROTAC linker designed for the construction of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the effective ubiquitination and degradation of target proteins, enhancing the study of protein homeostasis and regulation. It serves as a valuable tool in drug discovery and development, particularly in exploring targeted protein degradation pathways. -
PROTAC Linker
N-(Azido-PEG2)-N-Boc-PEG4-acid is a PEG-based linker designed for PROTAC synthesis, functioning effectively in targeted protein degradation applications. Featuring an azide functional group, this compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its robust reactivity makes it a valuable tool in chemical biology for the development of innovative therapeutics and advanced research applications. -
PROTAC Linkers
Pyrroline-5-carboxylate is a versatile PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It features an alkyl/ether backbone that enhances connectivity between target proteins and E3 ligases, facilitating selective protein degradation. This compound is essential for researchers investigating targeted protein modulation and degradation pathways in various biological systems. -
PROTAC Linkers
Tos-PEG5-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of an E3 ligase ligand to a target protein, promoting selective degradation via the ubiquitin-proteasome system. Its key biological activity lies in enhancing the effectiveness of targeted protein degradation strategies, making it valuable for research in cancer therapy and other diseases involving protein misregulation. -
PROTAC Linker
m-PEG4-Tos is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation compounds. It facilitates the efficient conjugation of various ligands, enhancing the selectivity and efficacy of PROTACs in modulating protein levels within cells. m-PEG4-Tos is instrumental in chemical biology research, particularly in studies focused on targeted protein manipulation and therapeutic development. -
PROTAC Linker
Hydroxy-PEG5-acid is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and bioavailability of PROTACs, facilitating the efficient recruitment of E3 ligases for targeted protein degradation. Its application is significant in drug discovery, particularly in the development of novel therapeutics that manipulate protein levels within cells. -
PROTAC Linker
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker that facilitates the development of targeted protein degradation strategies. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing substrates, including those with DBCO or BCN groups. Its versatility makes it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linkers
Fmoc-NH-PEG11-CH2CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates targeted protein degradation by connecting the E3 ligase to the protein of interest, enhancing the efficiency of PROTAC constructs in cellular assays. Its versatile structure allows for the development of novel bioconjugates and applications in drug discovery and cancer research. -
PROTAC Linker
Aminooxy-PEG3-C2-thiol is a PEG-derived linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound exhibits the ability to facilitate the conjugation of target proteins with E3 ligases, promoting the selective degradation of unwanted proteins through the ubiquitin-proteasome system. Its application in PROTAC development supports research in targeted protein degradation, with significant implications for therapeutic advancements in various diseases. -
PROTAC Linker
S-acetyl-PEG4-propargyl is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs by linking target proteins with E3 ligases, promoting targeted protein degradation. Its unique structure enhances solubility and stability, making it an essential tool for research in targeted protein modulation and drug discovery. -
PROTAC Linkers
HO-PEG17-OH is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of PROTACs by enabling the selective degradation of target proteins via the ubiquitin-proteasome system. Its unique structure enhances solubility and stability, making it suitable for a range of research applications in drug discovery and development aimed at modulating protein levels in various biological pathways. -
PROTAC Linkers
NH-bis(C1-PEG1-Boc) is a versatile alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the construction of bifunctional molecules that can selectively target and degrade specific proteins within cellular environments. Its application in PROTAC development enables researchers to explore targeted protein degradation mechanisms for therapeutic purposes. -
PROTAC Linker
Chloroacetamido-PEG4-C2-Boc is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a chloroacetamido group which enhances solubility and stability during the drug development process. It is primarily used in research applications focused on targeted protein degradation, enabling the selective degradation of specific proteins within cellular environments. -
PROTAC Linker
Hydroxy-PEG3-MS is a polyethylene glycol (PEG)-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the assembly of bifunctional molecules by linking a target protein ligand to an E3 ligase recruiter. Its hydrophilic nature enhances solubility and improves cellular permeability, making it suitable for diverse applications in targeted protein degradation research. -
PROTAC Linker
S-acetyl-PEG4-Boc is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the optimal interaction between target proteins and E3 ligases, enhancing the degradation of selected proteins under study. This linker is essential for researchers investigating targeted protein degradation and developing novel therapeutic approaches. -
PROTAC Linkers
Boc-N-PEG5-C2-NHS ester is a PEG-based PROTAC linker designed for applications in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation pathways. Its versatility makes it valuable for research in targeted protein degradation, thereby assisting in the exploration of novel therapeutic strategies. -
PROTAC Linker
DNP-PEG4-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a suitable spacer that enhances the solubility and bioavailability of the resulting PROTACs. It is essential for facilitating the selective degradation of target proteins, making it a valuable tool in drug discovery and development research. -
PROTAC Linkers
Folate-PEG2-amine is a polyethylene glycol (PEG)-derived linker specifically designed for the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the selective degradation of target proteins by linking E3 ligase recruiters to protein targets. Folate-PEG2-amine is particularly useful in cancer research and drug discovery, enabling the development of targeted therapies through enhanced protein management. -
PROTAC Linkers
Boc-NH-PEG2-NH-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). Its bifunctional structure facilitates the conjugation of target proteins and E3 ligases, thereby enhancing protein degradation. This reagent is essential for research applications focused on the development of PROTAC strategies in targeted protein degradation and therapeutic discovery. -
PROTAC Linkers
Bis-propargyl-PEG1 is a PEG-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group that allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules. It serves as a crucial component in the development of targeted protein degradation strategies, enhancing the versatility and effectiveness of PROTAC methodologies in chemical biology research. -
PROTAC Linkers
Azido-PEG2-C1-Boc is a versatile PEG-based linker designed for PROTAC synthesis, utilizing its azide functionality for click chemistry applications. This compound participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynes and can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its efficient conjugation capabilities make it a valuable tool for researchers focusing on targeted protein degradation and protein interaction studies. -
PROTAC Linker
Azido-PEG10-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, as well as DBCO or BCN groups, respectively. Azido-PEG10-acid is essential for researchers engaged in targeted protein degradation studies and the development of innovative therapeutic strategies. -
PROTAC Linker
Diethylene Glycol Monobenzyl Ether is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting the targeted degradation of specific proteins in cellular systems. Diethylene Glycol Monobenzyl Ether is a valuable tool in biochemical research focused on protein homeostasis, therapeutic development, and the study of protein-protein interactions. -
PROTAC Linker
NH2-PEG2-methyl acetate is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. This linker enhances the stability and solubility of the resulting compounds, enabling efficient recruitment of E3 ligases for targeted protein degradation. It is particularly valuable in drug discovery and development, helping researchers to explore new therapeutic strategies through the modulation of protein levels in various biological contexts. -
PROTAC Linkers
NH-bis-PEG4 is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient conjugation of target proteins to E3 ligases, promoting targeted protein degradation. NH-bis-PEG4 is essential in the development of novel therapeutics and can be employed in various research applications within the realms of targeted protein modulation and drug discovery. -
PROTAC Linker
Bromo-PEG7-azide is a polyethylene glycol (PEG)-based linker for PROTAC (Proteolysis Targeting Chimeras) synthesis, facilitating targeted protein degradation. This compound features an azide functional group, enabling its use in click chemistry, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for researchers in chemical biology and drug development applications. -
PROTAC Linkers
Mal-amido-PEG24-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of PROTACs by providing a flexible and hydrophilic spacer that enhances solubility and target engagement. Its unique structure allows for the efficient coupling of ligands to E3 ligase, enabling targeted protein degradation in various research applications, including drug discovery and therapeutic development. -
PROTAC Linker
Bis-propargyl-PEG5 is a PEG-based linker specifically designed for PROTAC synthesis, facilitating targeted protein degradation. This compound exhibits notable utility in constructing synthetic carbohydrate receptors (SCRs) with potential anti-Zika virus activity. As a versatile click chemistry reagent, Bis-propargyl-PEG5 contains an alkyne functional group, allowing for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, thus expanding its applications in chemical biology and drug development. -
PROTAC Linker
N-Azido-PEG4-N-Boc-N-PEG3-Boc is a PEG-based linker designed for PROTAC synthesis, facilitating targeted protein degradation. Featuring an azide functional group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, specifically with DBCO or BCN-containing molecules. This reagent is essential for researchers developing novel therapeutic modalities through targeted degradation pathways. -
PROTAC Linker
m-PEG9-phosphonic acid is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation of the target protein. Its utilization is crucial in developing targeted protein degradation strategies for cancer research and other therapeutic applications. -
PROTAC Linker
Aminooxy-PEG3-bromide is a PEG-based linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). Its oxime formation capability facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of specific proteins within cellular systems. This compound is valuable for researchers focusing on the development of PROTACs for therapeutic interventions in various diseases. -
PROTAC Linker
Biotin-PEG3-propargyl is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This reagent facilitates the selective targeting and degradation of proteins, making it a valuable tool in chemical biology and therapeutic research. Biotin-PEG3-propargyl's properties enhance the versatility of PROTAC design and enable advanced studies in protein regulation and cellular processes.
