Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
HyNic-PEG2-DBCO is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its efficient click chemistry properties enable precise conjugation, making it valuable for studies in targeted protein degradation and therapeutic development. Applications of HyNic-PEG2-DBCO include the creation of custom PROTACs for probing biological pathways and evaluating protein interactions. -
PROTAC Linkers
N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with entities that have DBCO or BCN functionalities. This versatility makes it suitable for various applications in chemical biology and targeted protein degradation research. -
PROTAC Linkers
Ms-PEG2-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by improving the binding efficiency between the protein of interest and the E3 ligase. It is suitable for applications in chemical biology and drug discovery, enabling researchers to develop novel therapeutic strategies for treating various diseases through targeted protein degradation. -
PROTAC Linkers
Benzyl-PEG2-CH2COOH is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation by linking ligands to E3 ligases, thereby promoting the selective elimination of target proteins. It is an important tool for researchers exploring novel therapeutic strategies in cellular biology and drug development applications. -
PROTAC Linkers
Fmoc-N-PEG36-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of PROTAC molecules, enabling targeted degradation of proteins within cellular contexts. Its unique structure enhances solubility and stability, making it a valuable tool for researchers exploring targeted protein degradation in drug discovery and development. -
PROTAC Linkers
Tos-PEG6-C2-Boc is a PEG-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting moieties to E3 ligase ligands, enabling the selective degradation of specific proteins in cellular systems. Its application in PROTAC development supports advancements in targeted protein regulation and therapeutic discovery. -
PROTAC Linker
Fluorescein-PEG6-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of targeting moieties to E3 ligase ligands, promoting the targeted degradation of specific proteins. Its fluorescent properties enable visualization and tracking of the resulting PROTACs in biological assays and studies. Fluorescein-PEG6-NHS ester is suitable for applications in chemical biology, drug discovery, and protein degradation research. -
PROTAC Linkers
Fluorescein-PEG5-NHS ester is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a fluorescein moiety, enabling fluorescence-based detection and tracking of PROTACs in cellular assays. Its versatile structure facilitates the conjugation of ligands and the modulation of target protein degradation, supporting research in targeted protein degradation and drug discovery applications. -
PROTAC Linkers
Methyltetrazine-PEG8-NHS ester is a PEG-based linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound effectively connects a target protein and an E3 ligase for targeted degradation, enhancing the specific elimination of proteins in cellular systems. Its utility in PROTAC synthesis makes it an essential reagent for researchers exploring novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Lipoamide-PEG3-Mal is a polyethylene glycol (PEG)-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of the resulting conjugates, promoting efficient protein degradation through the ubiquitin-proteasome system. Lipoamide-PEG3-Mal is instrumental in advancing research in targeted protein degradation and drug discovery applications. -
PROTAC Linker
Mal-amido-PEG3-acid is a polyethylene glycol (PEG) based linker utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds. This conjugate facilitates targeted protein degradation by connecting target proteins with E3 ligases, contributing to the modulation of specific biological pathways. Its application is pivotal in drug discovery and therapeutic research aimed at exploring novel mechanisms of action for varied diseases. -
PROTAC Linkers
N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a PEG-based linker designed for use in the synthesis of PROTACs. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds, making it a versatile tool for targeted protein degradation research applications. -
PROTAC Linker
Biotin-PEG9-amine is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the modulation of targeted protein degradation by improving the solubility and biocompatibility of PROTAC constructs. Its biotin moiety enables affinity capture via streptavidin, enhancing the efficiency of target identification and validation in cellular studies. Biotin-PEG9-amine serves as a valuable tool in chemical biology and drug discovery research applications. -
PROTAC Linker
Cl-C6-PEG4-C3-COOH is a PROTAC linker designed for the synthesis of chloroalkane-based PROTACs, commonly referred to as HaloPROTACs. This compound facilitates the formation of targeted protein degradation systems by enabling specific interactions with target proteins. It is instrumental in studying protein dynamics and developing innovative therapeutic strategies that harness the ubiquitin-proteasome system for drug discovery and research applications. -
PROTAC Linkers
TCO-PEG4-biotin is a PEG-based PROTAC linker designed to facilitate the construction of PROTACs. This compound enhances the solubility and stability of the resulting bifunctional molecules, enabling targeted protein degradation. Its incorporation into PROTACs allows for selective modulation of target proteins, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linkers
TCO-PEG2-Sulfo-NHS ester is a PEGylated PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables efficient conjugation of targeting ligands to E3 ligases, enhancing cellular degradation of specific proteins. Its utility in drug discovery and development makes it a valuable tool for researchers investigating targeted protein degradation strategies. -
PROTAC Linkers
Fmoc-aminooxy-PFP ester is a versatile PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound features an aminooxy group that promotes target protein degradation through the recruitment of E3 ubiquitin ligases. It is instrumental in exploring targeted protein modulation and advancing drug discovery efforts. -
PROTAC Linker
endo-BCN-PEG3-acid is a PEG-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in enhancing target degradation by connecting ligands to E3 ligases. Its utility in protein modulation research positions it as a valuable tool for studies focusing on targeted protein degradation strategies in various diseases. -
PROTAC Linker
Boc-11-aminoundecanoic acid is an alkyl/ether-based PROTAC linker that facilitates the development of targeted protein degraders. This compound is essential for synthesizing bifunctional molecules that recruit E3 ligases for the selective degradation of proteins. It finds applications in protein engineering, drug discovery, and the study of protein function through targeted degradation. -
PROTAC Linkers
Benzyl-PEG5-amine functions as a PEG-based linker in the development of PROTACs (proteolysis-targeting chimeras). This reagent enhances solubility and offers flexibility in molecular design, facilitating targeted protein degradation. Its application is crucial in drug discovery and the exploration of targeted therapies for various diseases. -
PROTAC Linkers
TCO-PEG8-TFP ester is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing protein degradation processes. Its structural properties allow for improved solubility and cellular uptake, making it a valuable tool in targeted protein degradation research and drug discovery applications. -
PROTAC Linkers
Amino-PEG11-amine is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. This 11-unit polyethylene glycol (PEG) moiety facilitates the conjugation of two mono diethylstilbestrol (DES)-based ligands, offering a novel approach to enhance the selectivity and potency of estrogen receptor (ER) antagonists. It is particularly relevant for research focused on developing targeted therapies for breast cancer through improved endocrine resistance mechanisms. -
PROTAC Linkers
Boc-NH-PEG24-CH2CH2COOH is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound promotes the selective degradation of target proteins by linking E3 ligases with the protein of interest. Its application in chemical biology enables researchers to explore targeted protein degradation pathways and develop novel therapeutic strategies. -
PROTAC Linker
m-PEG6-amino-Mal is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a maleimide functional group that facilitates the conjugation of target proteins through a chemical linkage. Its ability to enhance cellular uptake and stability makes it an invaluable tool for research applications focusing on targeted protein degradation and therapeutic development. -
PROTAC Linkers
m-PEG12-Thiol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of stable linkages between target proteins and E3 ligases, promoting ubiquitination and subsequent protein degradation. It is particularly valuable in the development of targeted protein degradation strategies for research applications in cancer, neurodegenerative diseases, and other therapeutic areas. -
PROTAC Linkers
Ms-PEG4-MS is a PEG-based PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the connection between a target ligand and an E3 ligase recognition moiety, enhancing cellular degradation of specific proteins. Its application spans the development of therapeutic agents aimed at selectively modulating protein levels in various biological contexts. -
PROTAC Linker
Boc-NH-PEG4-MS is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of targeting moieties to E3 ligase ligands, enhancing the formation of bifunctional molecules that induce targeted protein degradation. Its unique structure allows for improved solubility and biocompatibility, making it a valuable tool in drug discovery and development for targeted therapies. -
PROTAC Linkers
Diketone-PEG4-Biotin is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the recruitment of E3 ligases, promoting targeted protein degradation. Its key applications include the development of innovative therapeutic agents that selectively degrade disease-related proteins, aiding research in drug discovery and therapeutic interventions. -
PROTAC Linker
Mal-PEG2-oxyamine is a polyethylene glycol (PEG)-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables effective conjugation between E3 ligases and target proteins, enhancing the recruitment and ubiquitination process. Its features make it a valuable tool in research applications focused on targeted protein degradation and therapeutic development. -
PROTAC Linker
Azido-PEG11-azide is a PEG-based PROTAC linker designed to facilitate the synthesis of protein degradation therapeutics. Featuring azide functional groups, it is a versatile click chemistry reagent capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, enabling effective modular assembly in drug development and chemical biology applications. -
PROTAC Linkers
Bis-aminooxy-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of targeting moieties to E3 ligases, enabling selective degradation of target proteins. Bis-aminooxy-PEG3 is particularly valuable in research applications aimed at studying protein function and therapeutic interventions through targeted protein degradation. -
PROTAC Linker
SPDP-C6-NHS ester is an alkyl/ether-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of specific target proteins to E3 ligases, enhancing the selective degradation of proteins in cellular studies. It plays a vital role in drug discovery and development by enabling targeted protein modulation and offers a valuable tool for investigating biological pathways. -
PROTAC Linker
HS-PEG3-CH2CH2NH2 is a PEGylated PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of efficient and selective PROTAC molecules by enhancing solubility and cellular uptake. It is essential for research applications focusing on targeted protein degradation and drug discovery in various therapeutic areas. -
PROTAC Linker
Glycyl-l-serine is a PROTAC linker that integrates glycine and serine to facilitate targeted protein degradation. This compound's unique structure supports the development of various PROTACs, enhancing their efficacy in selective protein removal. Glycyl-l-serine is particularly useful in the synthesis of advanced PROTAC molecules, including FPP29, making it an essential tool for researchers in the field of targeted protein degradation. -
PROTAC Linker
Propargyl-PEG2-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an alkyne functional group, it enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This compound facilitates targeted protein degradation studies, contributing to advancements in therapeutic research and drug development. -
PROTAC Linker
Propynyl-PEG1-Ac is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) applications. This compound features an alkyne group that facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is instrumental in the synthesis of advanced PROTACs, enabling the selective targeting and degradation of specific proteins, thereby advancing therapeutic research in drug discovery and development. -
PROTAC Linkers
N-(Acid-PEG2)-N-bis(PEG3-azide) serves as a PEG-based linker for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development. -
PROTAC Linker
Hydroxy-PEG5-C2-methyl ester is a polyethylene glycol (PEG)-derived PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and cellular permeability of PROTACs, thereby contributing to their efficacy in targeted protein degradation. Its application is pivotal in the synthesis of novel PROTACs for studying protein interactions and therapeutic development in various diseases. -
PROTAC Linkers
Azido-PEG8-CH2COO-PFP is a PEGylated PROTAC linker designed to facilitate the synthesis of targeted protein degraders. Functioning as a click chemistry reagent, it features an azide group that engages in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups. This compound is essential for researchers focused on developing novel therapeutic strategies through protein modulation. -
PROTAC Linkers
DBCO-PEG5-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary mechanism involves the DBCO group, which enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is essential for facilitating site-specific conjugation in PROTAC development, contributing to targeted protein degradation in cellular research and therapeutic applications. -
PROTAC Linker
Boc-C1-PEG3-C4-OH is a versatile PROTAC linker that incorporates an alkyl/ether composition, facilitating the development of a variety of PROTAC molecules. This compound effectively bridges two distinct ligands: one targeting an E3 ubiquitin ligase and the other directed towards the protein of interest. By harnessing the ubiquitin-proteasome system, PROTACs built with Boc-C1-PEG3-C4-OH demonstrate selective protein degradation capabilities, making them valuable tools for research in targeted protein modulation and therapeutic intervention. -
PROTAC Linker
Boc-Aminooxy-PEG4-NH2 is a PEG-derived linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of compounds that target specific proteins for degradation via the ubiquitin-proteasome system. Its efficient linkage properties enhance the effectiveness of PROTACs in various research applications, including targeted protein degradation and the study of protein interactions. -
PROTAC Linkers
m-PEG3-succinimidyl carbonate functions as a PEG-based linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It enables the formation of stable connections between target proteins and E3 ligases, facilitating targeted protein degradation. This compound is valuable in drug discovery and development, particularly in studies focused on modulating protein levels and function through innovative therapeutic strategies. -
PROTAC Linkers
m-PEG3-Aminooxy is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that can induce targeted protein degradation, thereby enabling selective modulation of protein levels within cells. m-PEG3-Aminooxy is valuable for researchers investigating protein-protein interactions, cellular signaling, and targeted therapeutics. -
PROTAC Linkers
Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the effective conjugation of target proteins with E3 ligases, facilitating targeted protein degradation. Its versatility makes it suitable for various applications in drug discovery and development, particularly in studies focused on controlling protein levels in cellular contexts. -
PROTAC Linker
Chloro-PEG2-Boc is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the efficient coupling of target-binding ligands to E3 ligase recruitment moieties, enhancing the development of novel therapeutic agents. Its unique structure promotes solubility and bioavailability, making it an essential tool for researchers investigating targeted protein degradation pathways. -
PROTAC Linker
Fmoc-PEG3-C2-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC molecules. Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, thereby enhancing targeted protein degradation. This compound is essential for researchers investigating protein modulation and degradation pathways, offering a versatile tool for the development of innovative therapeutic strategies. -
PROTAC Linker
Sulfo DBCO-PEG4-Maleimide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This reagent features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted protein degradation. Its unique properties make it valuable for applications in chemical biology and drug discovery. -
PROTAC Linker
Cyclohexane-1,4-diamine is a versatile PROTAC linker utilized in the synthesis of targeted protein degraders. It serves to facilitate the assembly of PROTACs, enhancing their effectiveness in promoting ubiquitin-mediated degradation of specific proteins. This compound is essential for researchers engaged in drug development, particularly in the fields of oncology and targeted therapy applications. -
PROTAC Linker
tert-Butyl hex-5-ynoate serves as a crucial linker in the synthesis of PROTACs, specifically for the development of targeted protein degraders such as the cGAS degrader-1. This compound facilitates the creation of bifunctional molecules that engage the ubiquitin-proteasome system, thereby promoting the degradation of specific target proteins. Its application in PROTAC technology underscores its importance in advancing research in targeted therapeutics and protein modulation.
