Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
HS-PEG6-CH2CH2-Boc is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective conjugation of target proteins to E3 ligases, enabling selective degradation of intracellular proteins. Its utility in chemical biology makes it valuable for researchers focusing on targeted protein degradation and therapeutic interventions in various disease models. -
PROTAC Linker
(S,R,S)-AHPC-PEG4-tosyl is a PROTAC linker designed for targeted protein degradation applications. Featuring an E3 ligase ligand and a PEG4 spacer, this compound enhances solubility and hydrophilicity, facilitating improved delivery in biological systems. The tosyl group enables reactivity with amines and other nucleophiles, making it a versatile tool in drug research and discovery. -
PROTAC Linker
4-Chloro-1-butyne serves as a potent PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs, allowing for targeted degradation of specific proteins in cellular systems. It is particularly useful in studies focused on protein interactions and modulation of cellular pathways. -
PROTAC Linker
4,4'-(Propane-1,3-diylbis(oxy))dianiline serves as an effective PROTAC linker, facilitating the development of PROTAC (proteolysis-targeting chimeras) compounds. By linking a target protein to an E3 ubiquitin ligase, this compound enhances the targeted degradation of specific proteins, making it invaluable for research in cellular regulation and therapeutic development. Its usage is pivotal in studies aimed at understanding protein homeostasis and targeted drug design. -
PROTAC Linker
Tert-Butyl 3-(3-iodopropyl)azetidine-1-carboxylate is an effective PROTAC linker designed for synthesizing Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the degradation of specific proteins by promoting the recruitment of E3 ligases, providing a powerful tool for targeted protein modulation in biological research. It is applicable in studies focused on targeted protein degradation and can aid in the exploration of therapeutic strategies in various disease contexts. -
PROTAC Linker
Methyl 8-oxooctanoate is a versatile PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). It plays a crucial role in the development of novel therapeutic agents by linking target proteins to E3 ligases, thus promoting ubiquitination and degradation. This compound is essential for researchers investigating targeted protein degradation and its implications in various diseases. -
PROTAC Linker
5-Iodopentan-1-ol is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in creating potent and selective modulators of protein function by enabling the targeted degradation of specific proteins. It is essential for researchers focused on developing innovative therapeutic strategies in the fields of drug discovery and protein engineering. -
PROTAC Linker
4-Chlorobutyronitrile is a reactive PROTAC linker utilized in the synthesis of proteolysis-targeting chimera (PROTAC) molecules. It facilitates the assembly of bifunctional small molecules designed to selectively degrade target proteins through the ubiquitin-proteasome system. This compound is valuable in the development of targeted protein degradation strategies for various therapeutic applications, including cancer research and neurological disorders. -
PROTAC Linker
Piperidin-4-amine-C5-O-C1 is a PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). It serves as a critical component in the development of bifunctional molecules designed to selectively degrade target proteins via the ubiquitin-proteasome system. This compound enables researchers to explore innovative therapeutic strategies in targeted protein degradation, advancing the field of molecular biology and drug discovery. -
PROTAC Linker
3-(Azetidin-3-yl)propan-1-ol serves as a critical PROTAC linker, facilitating the creation of proteolysis-targeting chimeras (PROTACs). This compound contributes to the selective degradation of target proteins via the ubiquitin-proteasome system. It is utilized in various research applications focused on targeted protein degradation, advancing the understanding of protein function and therapeutic intervention in diseases. -
PROTAC Linker
H2N-PEG4-Hydrazide is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing target degradation through the ubiquitin-proteasome system. H2N-PEG4-Hydrazide is essential for researchers exploring targeted protein degradation approaches in drug discovery and development. -
PROTAC Linker
3-(Methylamino)propanoic acid serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. Its structure is optimized for conjugation, enhancing the efficacy of bioconjugates in research applications focused on protein modulation and cellular control mechanisms. This compound is instrumental in advancing drug discovery efforts aimed at novel therapeutic strategies. -
PROTAC Linker
(S,R,S)-AHPC-PEG4-NHS ester is a PROTAC linker featuring an E3 ligase ligand connected by a PEG4 spacer, enhancing PROTAC drug discovery and development. Its NHS ester functionality allows for efficient coupling with amine-containing molecules, facilitating the formation of targeted protein degradation complexes. The PEG4 spacer further improves the solubility of the conjugated compounds, making this linker a valuable tool in chemical biology research and therapeutic applications. -
PROTAC Linker
14-((tert-Butoxycarbonyl)amino)tetradecanoic acid serves as a versatile PROTAC linker, facilitating the construction of targeted protein degraders. This compound enables the formation of bifunctional molecules that can selectively recruit E3 ligases to target proteins for ubiquitination and subsequent degradation. Its application is pivotal in the development of innovative therapeutics aimed at modulating protein levels and investigating cellular pathways. -
PROTAC Linker
4,4'-(Hexane-1,6-diylbis(oxy))dibenzonitrile serves as a PROTAC linker in the assembly of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of protein ligands, enhancing selective protein degradation in targeted therapeutic applications. Its structural properties make it suitable for the development of innovative treatments in cancer and other diseases. -
PROTAC Linker
Bn-PEG8-OBn is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This versatile linker facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of proteins of interest. Its application is significant in small molecule drug discovery and biological research, particularly in the development of targeted therapies. -
PROTAC Linker
tert-Butyl 2-(piperidin-4-yl)acetate hydrochloride is a versatile PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases to target proteins, enabling targeted degradation pathways. Its role in PROTAC development makes it essential for research applications in targeted protein modulation and therapeutic interventions. -
PROTAC Linker
OH-PEG3-Cl is a bifunctional linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This reagent facilitates the conjugation of target proteins to an E3 ligase, enabling the degradation of specific proteins through the ubiquitin-proteasome system. Its application is crucial in chemical biology for the development of targeted protein degradation strategies that can be used in therapeutic research and drug discovery. -
PROTAC Linker
Ethyl 7-oxoheptanoate serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in enhancing the degradation of specific target proteins through the recruitment of E3 ligases. Its application extends to research in targeted protein degradation, making it valuable for studies in cancer biology and other disease mechanisms. -
PROTAC Linker
1-Bromo-4-(4-bromobutyl)benzene acts as an effective PROTAC linker, facilitating the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enables the selective degradation of target proteins by bridging an E3 ligase and a protein of interest, thereby enhancing the efficiency of targeted protein degradation studies. Its utility in the development of novel therapeutic strategies makes it valuable for research in drug discovery and protein regulation. -
PROTAC Linker
3-Cyanocyclobutane-1-carboxylic acid serves as a synthetic linker for PROTAC (proteolysis-targeting chimera) development. This compound facilitates the formation of stable PROTACs, enabling targeted protein degradation by linking a target protein ligand to an E3 ligase ligand. Its unique structural properties make it valuable for research applications in protein modulation and therapeutics. -
PROTAC Linker
Ethyl hex-5-ynoate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial for researchers aiming to create novel protein degraders that target specific proteins for degradation in cellular systems. Its versatility and effectiveness make it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)piperazine-1-carboxylate is a specialized linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the targeted degradation of specific proteins by bridging E3 ubiquitin ligases with the target protein, enhancing the recruitment and subsequent ubiquitination. It is valuable in research applications focused on protein regulation and therapeutic discovery, particularly in cancer and neurodegenerative diseases. -
PROTAC Linkers
HO-PEG8-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of ligand molecules, enhancing the stability and solubility of PROTACs. HO-PEG8-CH2COOH is essential in chemical biology studies aimed at targeted protein degradation and provides a versatile tool for researchers developing novel therapeutic agents. -
PROTAC Linker
2-Propargyl-(trans)-4-cyclohexanediamine functions as a versatile PROTAC linker, enabling the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ubiquitin ligases, thereby enhancing the modulation of biological pathways. It is an essential tool in drug discovery and protein regulation research applications. -
PROTAC Linker
3-Hydroxy-2,2,4,4-tetramethylcyclobutan-1-one oxime serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation strategies. It enables the efficient combination of target proteins with E3 ligases, enhancing the design of PROTAC molecules. This compound is pivotal in biochemical research focused on modulating protein levels and exploring therapeutic potentials in various diseases. -
SMARCA2 PROTAC degrader
YD54 is a PROTAC designed to induce degradation of the SMARCA2 protein, exhibiting a DC50 of 3.5 nM. This compound utilizes a targeted approach to promote the ubiquitination and proteasomal degradation of SMARCA2, making it a valuable tool for studying SMARCA2-dependent biological processes. YD54 is suitable for applications in cancer research and cellular signaling investigations, where modulation of SWI/SNF complex activity is critical. -
STAT3 PROTAC Degrader
PROTAC STAT3 degrader-3 (S3D1) targets the STAT3 protein through a PROTAC-mediated degradation mechanism. This compound exhibits potent anticancer activity by facilitating the ubiquitination and subsequent proteasomal degradation of STAT3, a key oncogenic transcription factor. It is primarily applied in research focused on cancer biology, particularly in studies investigating the therapeutic potential of targeting the STAT3 signaling pathway. -
SMARCA2 Degrader
PROTAC SMARCA2 degrader-8 is a selective degrader targeting the SMARCA2 protein, exhibiting a DC50 of 28 nM in A375 cells. This compound facilitates the ubiquitination and subsequent proteasomal degradation of SMARCA2, thereby effectively reducing its cellular levels. It is particularly useful for studies investigating the role of SMARCA2 in various cancer types and for elucidating its mechanisms of action in cellular processes. -
BRD4 PROTAC
MS83 is a novel PROTAC that employs a KEAP1 ligand to target and degrade BRD4, along with its homologs BRD3 and BRD2. By harnessing the ubiquitin-proteasome system, MS83 facilitates targeted protein degradation, providing a powerful tool for dissecting the functional roles of BRD4 in cellular processes. This compound is particularly relevant for research on cancer and epigenetic regulation, offering insights into therapeutic strategies that leverage targeted protein degradation. -
BRD9 Degrader PROTAC
PROTAC BRD9 Degrader-5 is a proteolysis-targeting chimera (PROTAC) that facilitates the targeted degradation of the bromodomain-containing protein BRD9. This compound employs the cellular ubiquitin-proteasome pathway to promote the selective elimination of BRD9, leading to the modulation of biological pathways associated with cancer and other diseases. It serves as a valuable tool for researchers investigating the role of BRD9 in various cellular processes and therapeutic interventions. -
SMARCA2 Degrader degrader
SMARCA2 degrader-20 is a potent PROTAC that targets the SMARCA2 protein for degradation, exhibiting a DC50 of less than 100 nM in A549 cells. This degrader is valuable for studying the functional consequences of SMARCA2 depletion in cancer biology and epigenetic regulation. Its high efficacy facilitates research into targeted protein degradation strategies and their therapeutic potential in oncology. -
PROTAC Linker
tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in targeted protein degradation, enhancing the efficacy of therapeutic agents by promoting the ubiquitin-proteasome system. Its unique structure allows for selective degradation of specific proteins, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
20-Bromoicosanoic acid is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the recruitment of E3 ligases to specific target proteins, promoting targeted protein degradation. Its unique structure allows for effective conjugation with various moieties, making it a valuable tool for researchers investigating targeted therapeutics and protein modulation. -
PROTAC Linker
2-(1-benzylpiperidin-4-yl)ethan-1-amine is a versatile PROTAC linker that plays a critical role in the design and synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds between E3 ligases and target proteins, enabling targeted degradation of specific proteins within cellular systems. Its application is essential in innovative drug discovery and the study of protein homeostasis and regulation. -
PROTAC Linker
tert-Butyl 6-iodohexanoate serves as a PROTAC linker, facilitating targeted protein degradation through the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the synthesis of innovative therapeutics designed to selectively degrade unwanted proteins in various biological contexts, thereby advancing drug discovery and development efforts. Its chemical structure enhances conjugation and stability, making it a valuable tool in chemical biology research. -
PROTAC Linker
trans-4-Aminocyclohexanol hydrochloride is a versatile PROTAC linker that facilitates the development of Proteolysis Targeting Chimeras (PROTACs). This compound is instrumental in enabling targeted protein degradation, thereby providing valuable insights into protein function and regulation. Its application in synthetic biology enhances the efficiency of drug discovery and therapeutic development processes. -
PROTAC Linker
2-tert-Butyl 6-methyl 2-azaspiro[3.3]heptane-2,6-dicarboxylate serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in enhancing the selective degradation of target proteins via the ubiquitin-proteasome system. Its structural attributes support efficient conjugation to both ligands and E3 ligases, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
4-Ethoxycarbonylmethylphenylboronic acid pinacol ester serves as a versatile linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs). By facilitating the assembly of target proteins and E3 ligases, this compound enhances the selective degradation of specific proteins within cellular environments. Its application is crucial in drug discovery and development, particularly for targeting disease-related proteins in cancer and other disorders. -
PROTAC Linker
22-Methoxy-22-oxodocosanoic acid is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by engaging the E3 ubiquitin ligase pathway. It is instrumental in constructing novel therapeutic agents for the modulation of protein levels in various biological research applications. -
PROTAC Linker
Boc-pyrrolidine-cyclopentanamine is a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for the construction of bifunctional molecules that selectively induce the degradation of target proteins via the ubiquitin-proteasome pathway. Its structural features enable optimal interaction with E3 ligases, making it suitable for various research applications in targeted protein degradation studies. -
PROTAC Linker
Methyl 3-cyanopropanoate serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins through the recruitment of E3 ligases, proving essential for targeted protein modulation studies. Its chemical structure supports efficient synthesis and functional application in cellular research, making it valuable for studies in targeted therapy and protein homeostasis. -
PROTAC Linker
N-(3-Hydroxypropyl)carbamic acid benzyl ester serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the recruitment of E3 ligases to specific proteins of interest, thus promoting their ubiquitination and subsequent degradation. Its application is crucial in research focused on targeted protein degradation, providing a strategic approach to modulating protein levels for therapeutic investigation. -
PROTAC Linker
tert-Butyl 4-(4-cyanophenyl)piperazine-1-carboxylate serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound is essential in directing protein degradation pathways, enabling targeted modulation of protein levels within biological systems. Its application is valuable in drug discovery and development, especially for the study of protein interactions and cellular processes. -
PROTAC Linker
1,16-Dibromohexadecane is a versatile PROTAC linker that facilitates the design and synthesis of Protein Targeting Chimeras (PROTACs). Its structural properties allow for effective conjugation to target proteins, enhancing the degradation of unwanted proteins in cellular systems. This compound is essential for researchers focused on targeted protein degradation and drug discovery applications. -
PROTAC Linker
3-Benzyloxy-propionic acid methyl ester serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in creating bifunctional molecules that can selectively induce the degradation of target proteins via the ubiquitin-proteasome system. Its applications span various fields, including drug discovery and cellular signaling research, enabling advancements in targeted protein modulation. -
PROTAC Linker
11-Methoxy-11-oxoundecanoic acid serves as a PROTAC linker, facilitating the development of targeted protein degradation compounds. This reagent is utilized in the synthesis of PROTACs to selectively degrade specific proteins within cellular systems. Its unique structure enhances the binding efficiency and stability of PROTAC constructs, making it an essential tool for research in targeted therapeutics and protein modulation. -
PROTAC Linker
SCO-PEG3-NHS is a polyethylene glycol (PEG) linker featuring a terminal imine (NH) group, specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This linker facilitates the formation of stable PROTAC molecules, enhancing their effectiveness by promoting targeted protein degradation. SCO-PEG3-NHS is suitable for a variety of research applications, including drug discovery and the study of cellular protein regulation and turnover. -
PROTAC Linker
2-Boc-2-Azaspiro[3.3]heptane-6-methanesulfonate is a linker compound designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the degradation of specific proteins through the ubiquitin-proteasome pathway. Its application is significant in the advancement of targeted protein degradation research and therapeutic development. -
PROTAC Linker
tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate hydrochloride is a versatile PROTAC linker utilized in the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking E3 ubiquitin ligases to substrates, enabling targeted protein modulation. Its application is essential for advancing research in targeted therapy, particularly in the fields of cancer and other diseases characterized by dysfunctional protein expression.
