Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
HOOCCH2O-PEG4-CH2COOH is a symmetric polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of Homo-PROTACs, enabling targeted protein degradation in cellular systems. Its unique structure enhances solubility and biocompatibility, making it a valuable tool in drug development and biochemical research focused on modulating protein levels. -
PROTAC Linker
PC-Biotin-PEG4-NHS carbonate is a PEG-based linker designed for use in the synthesis of PROTACs. This compound functions as a bifunctional reagent to facilitate the conjugation of biotin to target proteins. Its utility in PROTAC development enables researchers to enhance protein degradation pathways for the study of cellular processes and disease mechanisms. This linker is essential for applications in targeted protein degradation and therapeutic research. -
PROTAC Linkers
DNP-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting targeted protein degradation pathways. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules, as well as with those bearing DBCO or BCN groups. Its utility in click chemistry enables precise conjugation strategies essential for advancing research in therapeutic protein modulation. -
PROTAC Linkers
Fmoc-PEG12-NHS ester is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This NHS ester form facilitates the conjugation of the PROTAC moiety to target proteins, enabling targeted degradation pathways. It is ideal for applications in drug discovery and development, particularly for those exploring targeted protein degradation mechanisms. -
PROTAC Linkers
Decaethylene glycol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligands and protein target moieties, enabling the effective targeted degradation of specific proteins within cells. It supports research into protein regulation and therapeutic development in various biological contexts, contributing to advancements in drug discovery and regenerative medicine. -
PROTAC Linkers
m-PEG9-acid is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the development of targeted protein degradation strategies by enhancing solubility and specificity. This compound is essential for researchers focusing on targeted protein modulation and therapeutic applications in cancer and other diseases through the PROTAC approach. -
PROTAC Linker
Biotin-PEG4-amide-Alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functionality that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its unique properties facilitate targeted protein degradation research, making it a valuable tool for bioconjugation and drug discovery applications. -
PROTAC Linker
Mal-amido-PEG4-acid is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the formation of PROTACs by connecting an E3 ligase ligand to a targeted protein ligand, enhancing the degradation of specific proteins within cells. Its application is critical in drug discovery and development, particularly for targeting hard-to-drug proteins in various therapeutic areas. -
PROTAC Linker
Fmoc-NH-PEG5-C2-NH2 is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of bifunctional molecules that engage the ubiquitin-proteasome system for targeted protein degradation. Its structure enhances solubility and biocompatibility, making it suitable for a variety of research applications in drug discovery and targeted therapy studies. -
PROTAC Linker
9-Bromononanoic acid functions as a PROTAC linker, facilitating the synthesis of targeted protein degradation agents. This compound is particularly suitable for constructing PROTACs aimed at FGFR1, enabling the selective degradation of this oncogenic protein. Its utility in the development of innovative therapeutic strategies underscores its importance in chemical biology and drug discovery. -
PROTAC Linker
Boc-N-PEG1-C2-NHS ester is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its NHS ester moiety facilitates efficient conjugation to target proteins, thereby enabling the construction of compounds that promote targeted protein degradation. This reagent is essential for advancing research in therapeutic strategies that leverage the ubiquitin-proteasome system for improved selective degradation of proteins. -
PROTAC Linkers
Thiol-PEG8-acid is a PEG-based linker designed for use in proteolysis-targeting chimera (PROTAC) synthesis. Its thiol functional group facilitates conjugation with target proteins, while the polyethylene glycol (PEG) moiety enhances solubility and bioavailability. This compound is essential for researchers developing PROTACs aimed at selective degradation of specific proteins, advancing studies in targeted protein modulation and therapeutic applications. -
PROTAC Linker
UV Cleavable Biotin-PEG2-Azide is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its UV-cleavable properties make it particularly useful for studying protein interactions and degradation pathways in cellular contexts. -
PROTAC Linkers
Biotin-PEG8-NHS ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds with targeted proteins, enhancing the selective degradation of specific cellular targets. It is instrumental in research applications involving targeted protein degradation, providing a versatile tool for advancing drug discovery and therapeutic strategies. -
PROTAC Linker
Amino-PEG3-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). This compound features an amino group that facilitates conjugation with targeting ligands and an acidic carboxylic group that enhances solubility. Amino-PEG3-CH2COOH is instrumental in the development of targeted protein degradation strategies, making it valuable for research in cancer therapeutics and other diseases involving aberrant protein levels. -
PROTAC Linker
DBCO-PEG4-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs. It features a dibenzocyclooctyne (DBCO) moiety, enabling reaction via strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is essential for the development of targeted protein degradation strategies, facilitating precise modular assembly in therapeutic research applications. -
PROTAC Linker
NH-bis(PEG3-azide) is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules. Additionally, NH-bis(PEG3-azide) can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized partners, making it a versatile tool in chemical biology and drug discovery research applications. -
PROTAC Linker
Mal-amido-PEG6-NHS ester is a PEGylated linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of proteins in cellular systems. Its high solubility and stability make it an ideal choice for developing novel therapeutic agents in targeted protein degradation research. -
PROTAC Linker
THP-PEG1-alcohol is a polyethylene glycol (PEG) based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its unique structure facilitates efficient conjugation between target proteins and E3 ligases, enhancing the targeted degradation of specific cellular proteins. This reagent is essential for researchers exploring targeted protein degradation and developing novel therapeutic strategies in cancer and other diseases. -
PROTAC Linkers
m-PEG6-thiol is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the assembly of PROTACs by providing solubility and stability, enhancing target protein degradation. Its primary applications include drug discovery and development within targeted protein degradation research. -
PROTAC Linker
m-PEG8-Br is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins and E3 ligases, thereby enhancing the specificity and efficacy of targeted protein degradation. Its application is crucial in cancer research and drug discovery, enabling the development of novel therapeutics aimed at selectively degrading undesirable proteins in various biological contexts. -
PROTAC Linker
Bromo-PEG6-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of novel protein degraders by enabling the recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent degradation. Its utility in chemical biology and drug discovery makes it a valuable tool for researchers focused on targeted protein modulation and therapeutic interventions. -
PROTAC Linker
Mal-amido-PEG12-NHS ester is a PEGylated linker specifically designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of various ligands to E3 ubiquitin ligases, thereby enabling targeted degradation of specific proteins within cells. Key applications include studies of protein regulation and degradation mechanisms, as well as development of novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Boc-aminoxy-PEG4-acid is a polyethylene glycol (PEG) derivative designed as a linker for PROTAC (Proteolysis Targeting Chimera) systems. It facilitates the conjugation of E3 ligase ligands and target proteins, thereby enhancing the efficiency of targeted protein degradation. This versatile linker is crucial for researchers developing PROTAC-based therapeutics and studying the principles of targeted protein modulation. Its PEG structure contributes to increased solubility and improved pharmacokinetic properties in biological applications. -
PROTAC Linker
endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. Featuring a bicyclo[6.1.0]nonyne (BCN) group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its robust click chemistry properties make it suitable for applications in protein degradation research and therapeutic development. -
PROTAC Linkers
TCO-PEG8-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enabling targeted degradation of proteins thought unsuitable for classical small-molecule approaches. It is a valuable tool for researchers investigating protein regulation, cellular signaling pathways, and therapeutic interventions through targeted protein degradation. -
PROTAC Linker
Biotin-PEG3-Mal is a biotin-conjugated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the selective degradation of target proteins by linking E3 ubiquitin ligases to the target proteins of interest. With its biotin moiety, Biotin-PEG3-Mal enables efficient capture and purification of PROTAC compounds, making it a valuable tool for drug discovery and cellular investigations into protein regulation. -
PROTAC Linker
Propargyl-PEG9-amine is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne group, enabling selective conjugation through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Propargyl-PEG9-amine enhances the bioconjugation process, facilitating the development of targeted protein degradation tools for various biological research applications. -
PROTAC Linkers
m-PEG4-SH is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligase, enabling targeted protein degradation. m-PEG4-SH is crucial for researchers seeking to develop novel PROTACs for applications in drug discovery and cellular protein regulation studies. -
PROTAC Linker
Mal-PEG2-NH2 TFA is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a versatile approach for enhancing the solubility and pharmacokinetic properties of PROTACs, facilitating targeted protein degradation. Mal-PEG2-NH2 TFA is essential for researchers aiming to develop selective degraders for therapeutic applications in diverse biological systems. -
PROTAC Linker
Fmoc-amino-PEG5-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a fluoromethoxycarbonyl (Fmoc) protecting group, facilitating the incorporation of amino acids into the PROTAC design. Its PEG linker enhances solubility and promotes cellular uptake, making it valuable for research applications focused on targeted protein degradation and therapeutic development. -
PROTAC Linkers
Amino-PEG2-CH2CH2-SH hydrochloride is a polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the development of bifunctional molecules, enabling targeted protein degradation with precision. Its biocompatible structure enhances solubility and stability, making it suitable for a variety of applications in chemical biology and drug discovery, particularly in the creation of novel therapies for previously intractable targets. -
PROTAC Linker
Dde Biotin-PEG4-alkyne is a PEG-based PROTAC linker featuring an alkyne group, facilitating the synthesis of PROTACs. This compound serves as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in the design of bifunctional molecules allows for enhanced targeted degradation of proteins, making it a valuable tool in chemical biology and therapeutic research. -
PROTAC Linker
Amino-PEG5-Boc is a polyethylene glycol (PEG) linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective conjugation of target proteins with E3 ligases, enhancing the targeted degradation of specific proteins within cellular systems. The utilization of Amino-PEG5-Boc in research applications allows for improved study of protein homeostasis and therapeutic interventions in various diseases. -
PROTAC Linker
DBCO-PEG4-Desthiobiotin is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a DBCO moiety that facilitates efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is essential for developing targeted protein degradation tools, enabling researchers to investigate protein function and cellular pathways through controlled protein turnover. -
PROTAC Linkers
Boc-NH-PEG8-C2-Br is a PEGylated PROTAC linker designed to facilitate the development of targeted protein degradation strategies. This compound enhances the solubility and efficacy of PROTAC molecules while promoting the selective degradation of target proteins through the ubiquitin-proteasome pathway. Its application spans various research efforts aimed at elucidating cellular mechanisms and therapeutic approaches in oncology and other disease models. -
PROTAC Linker
Azide-PEG12-alcohol serves as a PEG-based linker for the development of PROTACs, facilitating targeted protein degradation through a well-defined chemistry. This compound contains an azide functionality, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, Azide-PEG12-alcohol can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified substrates, making it an invaluable tool for advancing chemical biology and therapeutic research. -
PROTAC Linker
8-Boc-2,8-Diazaspiro[4.5]decane is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound provides suitable spacer functionality, facilitating the conjugation of E3 ligase recruiters to target proteins, thereby enhancing selective degradation mechanisms. It is instrumental in advancing research applications in targeted protein degradation and drug discovery efforts. -
PROTAC Linker
tert-Butyl 4-(bromomethyl)benzylcarbamate serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation molecules. This compound is instrumental in constructing bifunctional molecules that recruit E3 ligases to specific substrates, promoting ubiquitination and subsequent proteasomal degradation. Its application is crucial for researchers investigating the modulation of protein levels for therapeutic purposes in various diseases. -
PROTAC Linker
Ethyl hydroxyacetate serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis targeting chimeras (PROTACs). This compound enhances cellular degradation of specific proteins by connecting E3 ligases to target proteins, thereby promoting targeted protein degradation pathways. Its role is critical in advancing research in targeted therapies and protein modulation studies. -
PROTAC Linker
tert-Butyl N-{2-azaspiro[3.5]nonan-7-yl}carbamate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound's structural properties allow for effective engagement with target proteins, promoting ubiquitylation and degradation. It is instrumental in research focused on targeted protein degradation and the design of novel therapeutic agents. -
PROTAC Linker
tert-Butyl (trans-4-(hydroxymethyl)cyclohexyl)carbamate serves as a versatile PROTAC linker that facilitates the design and synthesis of targeted protein degraders. This compound enhances the stability and activity of PROTACs by providing a robust covalent attachment point. Its unique structure contributes to improved cellular permeability and selectivity, making it a valuable tool in the development of innovative therapies for the modulation of protein targets in cancer and other diseases. This reagent is suitable for researchers working in drug discovery and development focusing on protein degradation pathways. -
PROTAC Linker
Sodium 5-hydroxypentanoate is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the effective recruitment of E3 ligases to target proteins, thereby promoting their degradation via the ubiquitin-proteasome system. This compound is essential for research in targeted protein degradation, enabling investigations into protein function and regulation. -
PROTAC Linker
2-(4-Bromobutyl)-1,3-dioxolane is a potent PROTAC linker, facilitating targeted protein degradation through the development of bifunctional molecules. This compound is essential in synthesizing PROTACs, which function by harnessing the cellular ubiquitin-proteasome system to selectively degrade specific protein targets. Its unique structure enhances the efficiency of protein recruitment and degradation, making it valuable for research in targeted therapies and drug discovery. -
PROTAC Linker
3-(1-(Tert-butoxycarbonyl)azetidin-3-yl)cyclobutane-1-carboxylic acid serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables targeted degradation of specific proteins, thereby advancing research in therapeutic strategies for diseases driven by dysfunctional proteins. Its structural properties support the efficient formation of ligand-linker conjugates, enhancing the development of innovative pharmacological agents. -
PROTAC Linker
1,3-Propanedithiol serves as a versatile PROTAC linker facilitating the synthesis of proteolysis-targeting chimera (PROTAC) molecules. This compound supports the development of targeted protein degradation strategies by providing a stable and flexible connection between the ligand and E3 ligase. Its unique properties enhance the efficiency and specificity of PROTAC formulations in various research applications related to cellular regulation, targeted therapy, and drug discovery. -
PROTAC Linker
1,4-Bis(2-bromoethoxy)benzene serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. Its structure promotes effective conjugation with warheads and E3 ligase recruiters, enabling efficient degradation of specific target proteins. This compound is essential for researchers aiming to explore novel therapeutic avenues in cancer and other diseases through targeted degradation strategies. -
PROTAC Linker
Hydroxy-PEG2-acid is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of PROTACs by connecting target proteins and E3 ligases, thereby promoting targeted degradation of specific proteins within cellular systems. Hydroxy-PEG2-acid is instrumental in advancing research in targeted protein degradation, offering potential therapeutic strategies in various diseases. -
PROTAC Linker
4-BocNH-Bicyclo[2.2.2]octane-COOH is a synthetic linker specifically designed for the development of PROTAC (proteolysis targeting chimeras) molecules. It facilitates the covalent attachment of target protein ligands with E3 ligase recognition elements, promoting targeted protein degradation. This compound is instrumental in chemical biology research, particularly in studies exploring targeted therapy and protein modulation. -
PROTAC Linker
Boc-10-Aminodecanoic acid is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs) and other conjugation applications. This compound features an alkane chain with a terminal carboxylic acid and Boc-protected amino groups, facilitating efficient formation of stable amide bonds when reacted with primary amines in the presence of coupling agents such as EDC or HATU. The Boc group can be deprotected under mild acidic conditions to yield the free amine, enabling further functionalization and applications in targeted protein degradation research.
