Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
tert-Butyl (4-aminobutyl)carbamate hydrochloride is a PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the design of bifunctional molecules that promote targeted degradation of proteins, enabling advanced studies in cellular signaling and protein homeostasis. Its use in the development of selective proteolysis tools enhances the potential for therapeutic interventions in a variety of diseases through targeted protein modulation. -
PROTAC Linker
tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate is a versatile PROTAC linker utilized for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligand-recruiting units to E3 ligase components, enabling targeted protein degradation. Its application in chemical biology research supports the development of novel therapeutic strategies by enhancing the specificity and efficacy of PROTAC formulations. -
PROTAC Linker
Trans-1,4-Bis(hydroxymethyl)cyclohexane serves as an effective linker for PROTAC (proteolysis targeting chimera) synthesis. Its structural characteristics facilitate the conjugation of ligands and E3 ligase Recruiters to target proteins, enhancing targeted protein degradation pathways. This compound is valuable in the development of PROTACs for research applications focusing on ubiquitin-proteasome system modulation and therapeutic intervention in various diseases. -
PROTAC Linker
6-Amino-1-hexyne serves as a versatile PROTAC linker, facilitating the development of targeted protein degraders. This compound enhances the stability and efficacy of PROTACs, promoting selective degradation of target proteins within cellular environments. Its application is essential in research focused on protein homeostasis and therapeutic interventions in various diseases. -
PROTAC Linker
1-(tert-Butoxycarbonyl)-3,3-difluoropiperidine-4-carboxylic acid is a specialized PROTAC linker designed for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the efficient conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. It is an essential building block for researchers engaged in studying protein regulation and degradation pathways in various biological contexts. -
PROTAC Linker
1-Boc-4-cyanopiperidine is a versatile PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound plays a critical role in enhancing target specificity and promoting efficient protein degradation through the ubiquitin-proteasome system. Its utility in chemical biology makes it an essential component for researchers developing targeted therapies. -
PROTAC Linker
[(5-Bromopentyl)oxy](tert-butyl)dimethylsilane serves as a powerful PROTAC linker, facilitating the development of PROTAC molecules for targeted protein degradation. Its structure enables efficient conjugation, enhancing the efficacy and biological activity of PROTACs in various cellular contexts. This compound is particularly valuable for researchers exploring therapeutic strategies that involve targeted modulation of protein levels. -
PROTAC Linker
tert-Butyl 4-(methylamino)butylcarbamate serves as a key PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is crucial for the development of targeted protein degradation strategies, enabling researchers to investigate protein function and therapeutic interventions in various cellular contexts. Its versatile structure supports the effective conjugation of target ligands and E3 ligase recruiters in PROTAC assembly, making it an important tool in chemical biology research. -
PROTAC Linker
7-Amino-1-heptanol is a versatile PROTAC linker utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the formation of innovative drug conjugates by linking target proteins to E3 ligases, thereby enhancing targeted degradation processes. Its application is essential in drug discovery and development, particularly in the area of targeted protein modulation. -
PROTAC Linker
(9H-Fluoren-9-yl)methyl (2-bromoethyl)carbamate is a specialized PROTAC linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound serves as a critical building block in the synthesis of PROTACs, enabling targeted protein degradation for therapeutic applications. Its unique structure enhances the efficacy of target protein recruitment, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
6-Chloro-1-hexyne functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs, enabling targeted protein degradation pathways for therapeutic applications. Researchers utilize 6-Chloro-1-hexyne to enhance the efficacy of drug candidates by improving selectivity toward unwanted proteins. -
PROTAC Linker
9-Aminononanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain with terminal carboxylic acid and amine groups, allowing for reactive coupling with various functional groups, including carboxylic acids and activated NHS esters. Its amino group can efficiently form stable amide bonds, making it a valuable tool for research applications focused on targeted protein degradation pathways. -
PROTAC Linker
1-(Piperidin-4-yl)azetidin-3-ol acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the conjugation of targeting ligands to E3 ligase, essential for targeted protein degradation research. Its utility in synthesizing innovative PROTACs makes it valuable for studies aimed at modulating protein levels within various biological contexts. -
PROTAC Linker
tert-Butyl pent-4-ynoate is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins, enabling researchers to explore protein function and regulation. It is particularly valuable in studies related to drug discovery, cancer research, and therapeutic development. -
PROTAC Linker
3-(Piperidin-4-yl)propan-1-ol serves as a versatile linker in the synthesis of PROTAC molecules, facilitating targeted protein degradation. This compound features a piperidine moiety that enhances its suitability for creating sophisticated bifunctional constructs. Its unique structural properties allow researchers to explore new avenues in targeted therapeutics, contributing to advancements in drug development and cellular regulation. -
PROTAC Linker
endo-BCN-PEG2-C2-NHS ester functions as a PEG-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This linker is designed to enhance target specificity and efficacy in targeted protein degradation research. Its properties make it suitable for studies focusing on cellular signaling, protein homeostasis, and therapeutic interventions in various diseases. -
PROTAC Linker
Brigatinib C functions as a PROTAC linker, facilitating the targeted degradation of proteins through the ubiquitin-proteasome system. It plays a crucial role in the design of proteolysis-targeting chimeras (PROTACs), enhancing their ability to selectively eliminate disease-related proteins. This compound is essential for researchers studying targeted protein degradation and may contribute to the development of innovative therapeutic strategies in various disease models. -
PROTAC Linker
Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based linker designed for use in PROTAC synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation through the recruitment mechanism inherent to PROTAC technology. It serves as a critical building block for researchers investigating targeted therapy strategies and efficient modulation of protein levels in cellular systems. -
PROTAC Linker
Br-PEG4-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for PROTAC (proteolysis targeting chimera) applications. This versatile linker facilitates the conjugation of targeting ligands to E3 ligase recruiters, enabling the selective degradation oftarget proteins. It is suitable for synthesizing various PROTAC molecules, allowing researchers to investigate protein function and develop therapeutic agents that leverage targeted protein degradation mechanisms. -
PROTAC Linker
Propargyl-PEG3-bromide is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. It plays a crucial role in constructing bivalent small molecules for targeted protein degradation studies, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
Boc-NH-PEG5-CH2CH2COOH is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the development of bifunctional molecules that can selectively target and degrade specific proteins, thereby enabling advanced studies in targeted protein degradation and therapeutic applications. Its incorporation in PROTAC design may enhance solubility and bioavailability of the resultant complexes, making it a valuable tool in chemical biology research. -
PROTAC Linker
N-Boc-C1-PEG3-C3-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by enabling the construction of bifunctional molecules that engage E3 ligases. Its versatility makes it suitable for applications in drug discovery and the development of novel therapeutic strategies. -
PROTAC Linker
Bromo-PEG4-bromide is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). Its bromo functionality facilitates the covalent attachment of target proteins, enhancing specificity and efficacy in targeted protein degradation. This compound is pivotal for research applications involving the development of novel therapeutics that utilize PROTAC technology. -
PROTAC Linker
BocNH-PEG5-CH2CH2Br is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound effectively facilitates the conjugation of target proteins to E3 ligases, promoting the ubiquitin-proteasome pathway for targeted protein degradation. Its structural features enhance solubility and optimal spatial orientation, making it suitable for research applications in drug development and protein modulation studies. -
PROTAC Linkers
Amino-PEG5-amine is a polyethylene glycol (PEG) based linker of five ethylene glycol units, designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by linking an E3 ligase to a ligand, thereby promoting targeted protein destruction. Its notable solubility properties enhance the efficiency of PROTAC development in chemical biology research and therapeutic applications. -
PROTAC Linker
TBDMS-PEG4-OH is a PEG4-based PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the synthesis of PROTACs by connecting a target ligand to an E3 ligase, enhancing targeted protein degradation. Its unique structure allows for increased solubility and flexibility, making it ideal for various applications in chemical biology and drug discovery research. -
PROTAC Linkers
6-Maleimidocaproic acid sulfo-NHS sodium is a sulfonated linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to ubiquitin ligases, promoting targeted degradation of specific proteins within cellular systems. Its unique structure enhances solubility and stability, making it suitable for various applications in drug discovery and development focused on protein modulation. -
PROTAC Linker
Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound enhances solubility and flexibility, thereby improving the efficacy of targeted protein degradation. It is suitable for various research applications, particularly in the study of targeted therapies and cellular protein regulation. -
PROTAC Linker
Sulfo DBCO-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimera (PROTAC) synthesis. This compound facilitates targeted degradation of proteins by connecting E3 ubiquitin ligases to specific proteins of interest. Its application in PROTAC development enhances selectivity and efficacy in degradation pathways, supporting research in targeted protein modulation and therapeutic interventions. -
PROTAC Linkers
Biotin-PEG2-aldehyde is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. It facilitates the development of bifunctional molecules that promote targeted protein degradation, making it a valuable tool in broadening therapeutic strategies. This compound enhances the bioavailability and solubility of PROTACs, supporting applications in drug discovery and development for targeted cancer therapy. -
PROTAC Linker
Octaethylene glycol is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs by providing necessary structural flexibility and solubility, enhancing their stability and efficacy. It is essential for researchers working on targeted protein degradation and drug discovery applications. -
PROTAC Linker
SPDP-PEG4-NHS ester is a PEG-based PROTAC linker designed for targeted protein degradation applications. By facilitating the conjugation of E3 ligase ligands and target proteins, this compound enhances the synthesis of PROTAC molecules, thus enabling the selective degradation of proteins of interest. Its utility in research includes the exploration of protein interactions and therapeutic development in various biological contexts. -
PROTAC Linker
Acid-PEG4-C2-Boc is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates targeted degradation of specific proteins by linking E3 ligases to protein targets, making it suitable for applications involving the inhibition of mTOR. Its chemical properties enhance solubility and stability, aiding in the development of innovative therapeutic strategies. -
PROTAC Linker
Amino-PEG10-Boc is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of covalent complexes between target proteins and E3 ligases, enhancing targeted protein degradation. Its unique structure and flexibility enable efficient assembly for various research applications, including drug discovery and the study of protein dynamics. -
PROTAC Linker
Triethylene glycol monobenzyl ether serves as a PEG-based PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, thereby improving their efficacy in targeted protein degradation. It is applicable in chemical biology research, particularly in the development of innovative therapeutic strategies for diseases driven by protein dysregulation. -
PROTAC Linker
endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker specifically designed for the synthesis of PROTACs. This compound features a BCN group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It plays a crucial role in the development of targeted protein degradation strategies and is suitable for applications in drug discovery and chemical biology research. -
PROTAC Linker
Benzaldehyde-PEG4-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting targeted protein degradation pathways. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds, facilitating diverse chemical coupling applications in chemical biology research. -
PROTAC Linker
Biotin-PEG3-C3-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring an amino (NH2) functional group, it facilitates the conjugation of biotin to target proteins, enhancing their degradation via the ubiquitin-proteasome system. This compound is instrumental for researchers investigating targeted protein degradation mechanisms and developing novel therapeutic strategies. -
PROTAC Linkers
NH-bis(C2-PEG2-NH-Boc) is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its dual amine functionality allows for effective conjugation to both target proteins and E3 ligases, facilitating targeted protein degradation. This reagent is essential for researchers aiming to develop novel PROTAC molecules for therapeutic applications in various disease models. -
PROTAC Linker
ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation by linking E3 ligases to specific cellular proteins, enhancing the selective elimination of undesirable proteins. Its role in PROTAC development positions it as a valuable tool in drug discovery and cancer research applications. -
PROTAC Linker
Azido-PEG4-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynyl-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with reagents containing DBCO or BCN groups. This versatility makes Azido-PEG4-azide a valuable tool for bioconjugation and targeted protein degradation studies. -
PROTAC Linkers
Propargyl-PEG2-NHS ester is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It functions as a click chemistry reagent due to its alkyne moiety, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties make it suitable for targeted protein degradation studies and the development of novel therapeutic strategies in chemical biology. -
PROTAC Linker
FmocNH-PEG3-CH2CH2NH2 hydrochloride is a polyethylene glycol (PEG)-based linker designed for proteolysis-targeting chimeras (PROTACs). It facilitates the conjugation of ligands to target proteins, enhancing the selective degradation of unwanted proteins in cellular models. This compound is essential for researchers investigating targeted protein degradation pathways and developing innovative therapeutic strategies. -
PROTAC Linkers
Hydroxy-PEG4-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of ligands to E3 ubiquitin ligases, promoting the targeted degradation of specific proteins. It is pivotal in the development of novel therapeutic strategies in oncology and other fields of biomedical research, enabling researchers to explore the potential of targeted protein modulation. -
PROTAC Linkers
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid primarily functions as a PEG-based linker for the synthesis of PROTACs. This compound features an azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds. The application of this reagent facilitates the development of targeted protein degradation systems in chemical research. -
PROTAC Linker
Methyl-PEG2-alcohol is a polyethylene glycol (PEG) based linker specifically designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). This compound facilitates the conjugation of a ligand to an E3 ubiquitin ligase, enabling targeted protein degradation. Its application in PROTAC development allows researchers to study protein function and degradation pathways, contributing to advancements in therapeutic discovery and drug development. -
PROTAC Linkers
Bis-PEG10-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of ligands to target proteins, enhancing the efficacy of targeted protein degradation. Bis-PEG10-acid is essential for researchers developing novel therapeutic strategies through the PROTAC technology platform. -
PROTAC Linkers
m-PEG24-NH2 is a polyethylene glycol (PEG) based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the coupling of E3 ligase recruiting moieties with target proteins, promoting targeted protein degradation. Its use is essential in the development of novel therapeutic strategies in cancer research and other disease modalities by enabling selective modulation of protein levels. -
PROTAC Linker
N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker featuring a terminal azide group. It serves as an effective click chemistry reagent, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN groups. This linker enables the synthesis of bifunctional PROTACs, providing valuable tools for targeted protein degradation studies and advancing drug discovery efforts. -
PROTAC Linkers
Thiol-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins for enhanced degradation through the ubiquitin-proteasome pathway. Its primary applications include the development of targeted protein degradation strategies and study of protein modulation in various biological systems.
