Fig. 1 · Structure
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Boc-N-PEG1-C2-NHS ester
PROTAC Linker
Boc-N-PEG1-C2-NHS ester is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its NHS ester moiety facilitates efficient conjugation to target proteins, thereby enabling the construction of compounds that promote targeted protein degradation. This reagent is essential for advancing research in therapeutic strategies that leverage the ubiquitin-proteasome system for improved selective degradation of proteins.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1260092-55-4 |
| Applications | PROTAC Linker |
| Formula | C14H22N2O7 |
| Molecular Weight | 330.33 |
| SMILES | O=C(ON1C(CCC1=O)=O)CCOCCNC(OC(C)(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.