Fig. 1 · Structure
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Thiol-PEG8-acid
PROTAC Linkers
Thiol-PEG8-acid is a PEG-based linker designed for use in proteolysis-targeting chimera (PROTAC) synthesis. Its thiol functional group facilitates conjugation with target proteins, while the polyethylene glycol (PEG) moiety enhances solubility and bioavailability. This compound is essential for researchers developing PROTACs aimed at selective degradation of specific proteins, advancing studies in targeted protein modulation and therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 866889-02-3 |
| Applications | PROTAC Linkers |
| Formula | C19H38O10S |
| Molecular Weight | 458.56 |
| SMILES | O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCS |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.