Fig. 1 · Structure
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Mal-amido-PEG4-acid
PROTAC Linker
Mal-amido-PEG4-acid is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the formation of PROTACs by connecting an E3 ligase ligand to a targeted protein ligand, enhancing the degradation of specific proteins within cells. Its application is critical in drug discovery and development, particularly for targeting hard-to-drug proteins in various therapeutic areas.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1263045-16-4 |
| Applications | PROTAC Linker |
| Formula | C18H28N2O9 |
| Molecular Weight | 416.42 |
| SMILES | O=C(O)CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.