Fig. 1 · Structure
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tert-Butyl 5-bromoisoindoline-2-carboxylate
PROTAC Linker
tert-Butyl 5-bromoisoindoline-2-carboxylate serves as a PROTAC linker, facilitating targeted protein degradation mechanisms. This compound is instrumental in synthesizing various PROTACs, including the HSD17B13 degrader 1, which enables the modulation of protein levels within biological systems. Its structural properties make it a valuable tool in research applications focused on targeted therapy development and protein regulation studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 201940-08-1 |
| Applications | PROTAC Linker |
| Formula | C13H16BrNO2 |
| Molecular Weight | 298.18 |
| Synonyms | Tert-butyl 5-bromo-1,3-dihydro-2H-isoindole-2- carboxylate |
| SMILES | CC(C)(OC(N1CC2=CC=C(Br)C=C2C1)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.