AMPK

Inhibitory Selectivity
Catalog No.Inhibitor Name AMPK
A13720Dorsomorphin 2HCl
**
A14312WZ4003
****
A11970Dorsomorphin
**
A16281HTH-01-015
***
A11071A 769662
*
A15815ETC-1002

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A16284

YLF-466D

AMPK activator
YLF-466D is an allosteric AMPK activator.
A15896

GSK621

AMPK activator
GSK621 is a potent and selective AMPK agonist.
A15815 SALE

ETC-1002

ACL inhibitor and AMPK activator
ETC-1002 is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule; activator of hepatic AMP-activated protein kinase (AMPK); also has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).
A10717 SALE

Phenformin hydrochloride

-
Phenformin hydrochloride is a hydrochloride salt of phenformin from the biguanide drug class that displays anti-diabetic activity.
A14312

WZ4003

NUAK kinase inhibitor
WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2
A13720 SALE

Dorsomorphin 2HCl

BMP inhibitor
Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.
A11970 SALE

BML-275 (Dorsomorphin)

AMPK inhibitor
BML-275 is a cell-permeable pyrazolopyrimidine compound shown to be an AMP-activated protein kinase (AMPK) and fatty acid synthase inhibitor.
A10028 SALE

Acadesine (Aicar,NSC 105823)

AMPK activator

Acadesine is a selective activator of AMPK in both hepatocytes and adipocytes.

A16281

HTH-01-015

NUAK1 inhibitor
HTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members.
A16282

Imeglimin

oxidative phosphorylation blocker
Imeglimin is an oxidative phosphorylation blocker that acts to inhibit hepatic gluconeogenesis, increase muscle glucose uptake, and restore normal insulin secretion.
A16283

Imeglimin hydrochloride

oxidative phosphorylation blocker
Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and pancreatic ??-cells to uniquely target the key defects of type 2 diabetes.
A11071 SALE

A-769662

AMPK activator
A-769662 is a new activator of AMP-activated protein kinase (AMPK).

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