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AMPK activator

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Catalog No. A11071

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
A-769662 5mg A11071-5

Regular Price: €38.00

Special Price: €34.20

A-769662 10mg A11071-10

Regular Price: €61.75

Special Price: €55.58

A-769662 50mg A11071-50

Regular Price: €247.00

Special Price: €222.30

A-769662 100mg A11071-100

Regular Price: €456.00

Special Price: €410.40

A-769662 10mM * 1mL in DMSO A11071-10mM-D

Regular Price: €66.50

Special Price: €59.85

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

A-769662 is a new activator of AMP-activated protein kinase (AMPK).


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Publications citing Adooq Products
A-769662 Citations (3)
  • Lieberthal W, .et al. AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo, Am J Physiol Renal Physiol, 2019, 2019 PMID: 30995114
  • Kikuchi H, .et al. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease, Kidney Int, 2018, Nov 13. pii: S0085-2538(18)30635-5 PMID: 30455054
  • Schneider H, .et al. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle, Hypertension, 2015, Jul;66(1):108-16 PMID: 26034200

Chemical Information

Catalog Num A11071
Actions Activator
M. Wt 360.4
Formula C20H12N2O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 844499-71-4
Synonyms A769662
SMILES C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O

Biological Activity

A-769662 is a new activator of AMP-activated protein kinase (AMPK).
AMPK (Cell-free assay) Fatty acid synthesis (Cell-free assay)
0.8 μM(EC50)3.2 μM


Solubility (25°C) * In vitro DMSO 72 mg/mL (199.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.75 mL 138.73 mL 277.47mL
0.5 mM 5.55 mL 27.75 mL 55.49 mL
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL

*The above data is based on the productmolecular weight 360.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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