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Catalog No.: A11071

AMPK activator


A-769662 Chemical Structure

CAS NO. 844499-71-4

A-769662 is a new activator of AMP-activated protein kinase (AMPK).

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Daniel Missailidis, .et al. Dysregulated Provision of Oxidisable Substrates to the Mitochondria in ME/CFS Lymphoblasts, Int J Mol Sci., 2021, Feb; 22(4): 2046 PMID: 33669532
  • Lieberthal W, .et al. AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo, Am J Physiol Renal Physiol, 2019, 2019 PMID: 30995114
  • Kikuchi H, .et al. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease, Kidney Int, 2018, Nov 13. pii: S0085-2538(18)30635-5 PMID: 30455054
  • Schneider H, .et al. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle, Hypertension, 2015, Jul;66(1):108-16 PMID: 26034200

Biological Activity

A-769662 is a new activator of AMP-activated protein kinase (AMPK).
AMPK (Cell-free assay) Fatty acid synthesis (Cell-free assay)
0.8 μM(EC50)3.2 μM
In vitro (25°C) DMSO 65 mg/mL (180.36 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.75 mL 138.73 mL 277.47 mL
0.5 mM 5.55 mL 27.75 mL 55.49 mL
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL

*The above data is based on the productmolecular weight 360.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11071
Actions Activator
CAS No. 844499-71-4
Formula C20H12N2O3S
M. Wt 360.4
Purity >98%
Synonyms A769662
SMILES C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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