PF-06409577

Catalog No.: A16801
AMPK activator
PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.
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Product Name Price Stock Qty
PF-06409577 5mg
Special Price $48.00 Regular Price $60.00
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PF-06409577 10mg
Special Price $80.00 Regular Price $100.00
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PF-06409577 50mg
Special Price $360.00 Regular Price $450.00
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Biological Activity
Discription PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.
Targets
Target Value
Product Information
Catalog Num A16801
Formula C19H16ClNO3
Molecular Weight 341.79
CAS Number 1467057-23-3
SMILES O=C(C1=CNC2=C1C=C(C3=CC=C(C4(O)CCC4)C=C3)C(Cl)=C2)O
Synonyms PF06409577, PF 06409577
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 63 mg/mL (184.32 mM)
Water Insoluble
Ethanol 63 mg/mL (184.32 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.26 mL 146.29 mL 292.58 mL
0.5 mM 5.85 mL 29.26 mL 58.52 mL
1 mM 2.93 mL 14.63 mL 29.26 mL
5 mM 0.59 mL 2.93 mL 5.85 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

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This equation is commonly abbreviated as: C1V1 = C2V2

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