Dorsomorphin 2HCl

Catalog No.: A13720

BMP inhibitor

Dorsomorphin 2HCl Chemical Structure

CAS NO. 1219168-18-9

Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.

Availability: In stock

Package Price Qty
10 mg
$75.00
25 mg
$150.00
50 mg
$250.00
10mM * 1mL in DMSO
$55.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.
Targets
AMPK (Cell-free assay)
109 nM(Ki)
In vitro (25°C) DMSO <1 mg/mL (<1 mM)
Water 94 mg/mL (198.97 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.17 mL 105.84 mL 211.68 mL
0.5 mM 4.23 mL 21.17 mL 42.34 mL
1 mM 2.12 mL 10.58 mL 21.17 mL
5 mM 0.42 mL 2.12 mL 4.23 mL

*The above data is based on the productmolecular weight 472.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13720
Actions Inhibitor
M. Wt 472.41
Formula C24H27Cl2N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1219168-18-9
Synonyms Compound C, BML-275, BML275, BML 275
SMILES C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

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