Endothelin Receptors



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Catalog No. Product Name Application Product Information
A11291

Ambrisentan (BSF 208075)

EndothelinA receptor antagonist
Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).
A15007

Atrasentan HCl

Endothelin antagonist receptor
Atrasentan hydrochloride is an endothelin antagonist receptor (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
A11301

Avosentan (SPP301)

Endothelin antagonist
Avosentan (SPP301) is a potent and highly selective ETA receptor blocker.
A11091

Bosentan

ETAR/ETBR inhibitor
Bosentan is a competitive antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
A11492

Macitentan

Endothelin receptor antagonist
Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
A13216

RO462005

endothelin receptor agonist
RO462005 is an endothelin receptor selective agonist.
A11564

Sitaxsentan sodium (TBC-11251)

ETA receptor antagonist
Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively.
A11006

Zibotentan (ZD4054)

ETA-receptor Antagonist
Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).

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