Bosentan Hydrate

Catalog No.: A14944

ET-A and ET-B antagonist

Bosentan Hydrate

Bosentan Hydrate Chemical Structure

CAS NO. 157212-55-0

Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

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Biological Activity

Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.
In vitro (25°C) DMSO 92 mg/mL (161.51 mM)
Water Insoluble
Ethanol 2 mg/mL (3.51 mM)
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.56 mL 87.78 mL 175.55 mL
0.5 mM 3.51 mL 17.56 mL 35.11 mL
1 mM 1.76 mL 8.78 mL 17.56 mL
5 mM 0.35 mL 1.76 mL 3.51 mL

*The above data is based on the productmolecular weight 569.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14944
Actions Antagonist
CAS No. 157212-55-0
Formula C27H29N5O6S.H2O
M. Wt 569.63
Purity >98%
Synonyms Ro 47-0203

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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