JNK/c-Jun



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Catalog No. Product Name Application Product Information
A11281

AEG 3482

JNK inhibitor
AEG 3482 is a small-molecule inhibitor of Jun kinase (JNK)-dependent apoptosis.
A11296

AS 602801 (Bentamapimod)

JNK inhibitor
AS 602801 is a novel, orally active, Jun Kinase Inhibitor.
A13683

BI-78D3

JNK inhibitor
BI-78D3 is a competitive JNK (c-Jun N-terminal kinases) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38?? and no activity at mTOR and PI-3K. BI 78D3 inhibits JIP1(JNK interacting protein 1)-JNK binding (IC50 = 500 nM).
A11352

CC-401

JNK inhibitor
CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
A15037

CC-401 hydrochloride

JNK inhibitor
CC-401 hydrochloride is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
A13564

CC-930

JNK inhibitor
CC-930 is a selective c-Jun amino-terminal kinase (JNK) inhibitor and is currently under clinical development for fibrotic and infammatory indications.
A13565

CEP-1347

JNK inhibitor
CEP-1347 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. It rescues motor neurons undergoing apoptosis (EC50 = 20 nM).
A15061

DB07268

JNK1 inhibitor
DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.
A16059

DTP3

JNK inhibitor
DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-kB survival pathway.
A16036

IQ 3

JNK3 inhibitor
IQ 3 is a selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-kB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 ??M). Also inhibits TNF-α and IL-6 production in vitro.
A16062

IQ-1S

JNK3 inhibitor
IQ-1S is a Selective JNK3 inhibitor with IC50 value of 390, 360 and 87 nM for JNK1, 2 and 3 respectively.
A16041

JIP-1 (153-163)

JNK inhibitor
JIP-1 (153-163) is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.
A15136

JNK-IN-7

JNK Inhibitor
JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C.
A12749

JNK-IN-8

JNK Inhibitor
JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively
A10860

SP600125

JNK inhibitor
SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3.
A16039

SU 3327

JNK inhibitor
SU 3327 is a selective inhibitor of JNK (c-Jun N-terminal kinase)(IC50 = 0.7uM). SU 3327 is shown to inhibit the protein-protein interaction between JNK and JIP (IC50 = 239 nM).
A11969

TCS JNK 5a

JNK Inhibitor IX
TCS JNK 5a is a highly selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38?? respectively).
A16054

TCS JNK 6o

JNK inhibitor
TCS JNK 6o is a ATP-competitive and selective c-Jun N-terminal kinase (JNK) inhibitor.

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