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- Shuai Zhang, .et al. AS602801 sensitizes glioma cells to temozolomide and vincristine by blocking gap junction communication between glioma cells and astrocytes, J Cell Mol Med, 2021, Apr;25(8):4062-4072 PMID: 33609076
- Kuramoto K, .et al. AS602801, an Anti-Cancer Stem Cell Drug Candidate, Suppresses Gap-junction Communication Between Lung Cancer Stem Cells and Astrocytes, Anticancer Res, 2018, Sep;38(9):5093-5099 PMID: 30194154
Biological Activity
AS 602801 is a novel, orally active, Jun Kinase Inhibitor.
| In vitro | DMSO | 21 mg/mL (45.89 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.86 mL | 109.29 mL | 218.58 mL |
| 0.5 mM | 4.37 mL | 21.86 mL | 43.72 mL |
| 1 mM | 2.19 mL | 10.93 mL | 21.86 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11296 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 848344-36-5 |
| Formula | C25H23N5O2S |
| M. Wt | 457.5 |
| Purity | >98% |
| Synonyms | AS-602801, AS602801 |
| SMILES | C1COCCN1CC2=CC=C(C=C2)COC3=NC=CC(=N3)C(C#N)C4=NC5=CC=CC=C5S4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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