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IQ 3 is a selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-kB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.
| In vitro | DMSO | 9 mg/mL (26.36 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.3 mL | 146.49 mL | 292.98 mL |
| 0.5 mM | 5.86 mL | 29.3 mL | 58.6 mL |
| 1 mM | 2.93 mL | 14.65 mL | 29.3 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.86 mL |
*The above data is based on the productmolecular weight 341.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16036 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 312538-03-7 |
| Formula | C20H11N3O3 |
| M. Wt | 341.32 |
| Purity | >98% |
| Synonyms | IQ3, IQ-3 |
| SMILES | C1=CC=C2C(=C1)C3=NC4=CC=CC=C4N=C3C2=NOC(=O)C5=CC=CO5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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