renin-angiotensin-aldosterone system (RAAS)

Inhibitory Selectivity
Catalog No.Inhibitor Name AT1 receptorAT2 receptorACEReninRAAS
A11123Aliskiren Hemifumarate
***
A10175Candesartan
****
A10351Enalaprilat Dihydrate
***
***
****
A10477Irbesartan
***
A13201PD123319
*
A10710Perindopril Erbumine
***
A10176Candesartan Cilexetil
****
A10778Ramipril
**
A11738Captopril
*
A16420Azilsartan Medoxomil
**
A13747Eprosartan Mesylate
****
A11775Azilsartan
**
A10905Telmisartan
A10123Benazepril HCl
A10350Enalapril Maleate
A11615Olmesartan Medoxomil
A11747Cilazapril Monohydrate
A11876Lisinopril
A11745Moexipril HCl
A11749Temocapril
A11736Quinapril HCl
A14206LCZ696
A11748Fosinopril Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A11121 SALE

Eprosartan

AT1 receptor antagonist
Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure.
A16420

Azilsartan Medoxomil

angiotensin II receptor type 1 antagonist
Azilsartan medoxomil is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
A10778

Ramipril

ACE inhibitor
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
A14154

BIBS39

angiotensin II receptor antagonist
BIBS39 is a nonpeptide angiotensin II (AII) receptor antagonists that displaced [125I] AII from its specific binding sites with a K(i) value of 29 +/- 7 nM for the AII subtype I (AT1) receptor and a K(i) value of 480 +/- 110 nM for the AII subtype 2 (AT2) receptor.
A10891 SALE

Tasosartan

Angiotensin II receptor antagonist
Tasosartan is an angiotensin II receptor antagonist.
A13747 SALE

Eprosartan mesylate

-
Eprosartan (mesylate) is a competitive AT1 receptor antagonist with IC50 values ranging from 1.4 – 3.9 nM and an elimination half-life of five to seven hours.
A10905 SALE

Telmisartan

AT1 Antagonist
Telmisartan is an angiotensin II receptor antagonist that inhibits the angiotensin II AT1 receptor.
A12769

Zofenopril calcium

ACE inhibitor
Zofenopril calcium is an angiotensin-converting enzyme ACE inhibitor.
A11867

Imidapril (Tanatril)

-
Imidapril (Tanatril) is an inhibitor of angiotensin converting enzyme (ACE).
A11876 SALE

Lisinopril (Zestril)

-
Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
A10670

Olmesartan (RNH6270, CS-088)

-
Olmesartan is an angiotensin II receptor antagonist indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
A11615

Olmesartan medoxomil

-
Olmesartan medoxomil is an angiotensin II receptor antagonist used to treat high blood pressure. Olmesartan works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle. By blocking the binding rather than the synthesis of angiotensin II, olmesartan inhibits the negative regulatory feedback on renin secretion.
A11775 SALE

Azilsartan (TAK-536)

AT1 Receptor Blocker
Azilsartan (TAK-536) is an angiotensin II receptor antagonist used in the treatment of hypertension.
A11738 SALE

Captopril

-
Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure.
A11317

Moxonidine

-
Moxonidine is a new-generation centrally-acting antihypertensive drug. It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure. In addition, it demonstrates favourable effects on parameters of the insulin resistance syndrome, apparently independent of blood pressure reduction.
A11748 SALE

Fosinopril sodium

ACE inhibitor
Fosinopril is an angiotensin converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of chronic heart failure.
A10710 SALE

Perindopril Erbumine (Aceon)

-
Perindopril Butylamine Salt is an angiotensin-converting enzyme (ACE) inhibitor.
A13521

Captopril disulfide

LTA4 hydrolase inhibitor
Captopril Disulfide is a reversible and competitive inhibitor of LTA4 hydrolase (IC50=11 M). Captopril has been shown to be an of angiotensin converting enzyme-1 (ACE1), but not ACE2(IC50 = 22 nM).
A14859 SALE

Angiotensin I (human, mouse, rat)

-
Angiotensin I is formed by the action of renin on angiotensinogen.
A14862

Angiotensin (1-7)

-
Angiotensin (1-7) is an endogenous peptide fragment that can be produced from Ang I or Ang II via endo- or carboxy-peptidases respectively.
A14863 SALE

Angiotensin II

-
Angiotensin II (Ang II) is an octapeptide hormone that plays a central role in cardiovascular homeostasis.
A14864

Angiotensin III (human, mouse)

-
Angiotensin III is a hexapeptide formed as a result of a cleavage at the N-terminus of Angiotensin II, a key factor in the Renin-Angiotensin-Aldosterone (RAAS) system by angiotensinases located in red blood cells and the vascular beds of most tissues.
A14873 SALE

Angiotensin 1/2 (1-9)

-
Angiotensin 1/2 (1-9) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS) containing the amino acids 1-9 that are converted from Angiotensin I/II peptide.
A14883

Acetyl Angiotensinogen (1-14), porcine

-
Acetyl Angiotensinogen (1-14),porcine, The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor.
A14886

Angiotensin 1/2 (1-5)

-
Angiotensin 1/2 (1-5) is a peptide that contains the amino acids 1-5 and is converted from Angiotensin I/II.
A14887

Angiotensin 1/2 (1-6)

-
Angiotensin 1/2 (1-6) is a peptide that contains the amino acids 1-6 and is converted from Angiotensin I/II peptide.
A14888

Angiotensin 1/2 + A (2 - 8)

-
Angiotensin 1/2 + A (2 - 8), potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II.
A15281

VTP-27999 2,2,2-trifluoroacetate

Renin inhibitor
VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
A15314

Spinorphin

Enkephalin-degrading and ACE inhibitor
Spinorphin is an endogenous factor that exhibits inhibitory effects on enkephalin-degrading enzymes.
A15451

EXP-3174

AT1 receptor antagonist
EXP-3174 is a potent and selective noncompetitive AT1 receptor antagonist with IC50 value of 37 nM.
A14206 SALE

LCZ696 (Valsartan)

angiotensin receptor-neprilysin inhibitor
LCZ696 is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure.
A13201 SALE

PD 123319 ditrifluoroacetate

angiotensin AT2 receptor antagonist
PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
A10351

Enalaprilat dihydrate

RAAS inhibitor
Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor and was developed partly to overcome these limitations of captopril.
A10175 SALE

Candesartan (Atacand)

RAAS antagonist
Candesartan is an angiotensin receptor blocker (also called an angiotensin-II receptor antagonist or an AIIRA).
A10123

Benazepril HCl

RAAS inhibitor

Benazepril hydrochloride is a non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

A11184 SALE

Clinofibrate

HMG-CoA Reductase inhibitor

Clinofibrate is a lipid clearing agent that appears to modify lipid metabolism, diminishing the steroid induced accumulation of lipids within osteocytes. It also can effectively reduce the plasma fibrinogen level.

A11122

Rosuvastatin

HMG-CoA reductase inhibitor
Rosuvastatin is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease.
A10477 SALE

Irbesartan (Avapro)

AT1 antagonist
Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
A11616 SALE

Aliskiren (CGP 60536)

Renin inhibitor
Aliskiren is an orally active, synthetic nonpeptide renin inhibitor.
A10176 SALE

Candesartan cilexetil (Atacand)

-
Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
A11736 SALE

Quinapril hydrochloride

-
Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I.
A11745 SALE

Moexipril hydrochloride

-
Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) which is used for the treatment of hypertension and congestive heart failure.
A11747

Cilazapril monohydrate

ACE inhibitor
Cilazapril is a pyridazine angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure.
A11749

Temocapril

ACE inhibitor
Temocapril is an ACE inhibitor.
A10350 SALE

Enalapril maleate

ACE inhibitor
Enalapril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension and some types of chronic heart failure.
A11123

Aliskiren hemifumarate

renin inhibitor
Aliskiren hemifumarate is a hemifumarate salt form of Aliskiren, which is a direct renin inhibitor approved for the treatment of essential hypertension.

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