Catalog No.
Product Name
Application
Product Information
Citations
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BB-22 Metabolite
BB-223-carboxyindole metabolite is a metabolite of the synthetic cannabinoid BB-22. As an analog of cannabinoids, it primarily interacts with the endocannabinoid system. This compound is significant for researchers studying cannabinoid metabolism and its physiological effects, providing insights into cannabinoid receptor interactions and their potential therapeutic applications. -
Cannabinoid Receptor
5-Fluoro PB-22 8-hydroxyisoquinoline isomer primarily targets cannabinoid receptors, exerting effects relevant to cannabinoid signaling pathways. This compound exhibits biological activity that may be useful in studies investigating the endocannabinoid system and its role in various physiological processes. Research applications include the exploration of cannabinoid receptor modulation, potential therapeutic effects, and the investigation of synthetic cannabinoid mechanisms of action. -
CB1 Positive Allosteric Modulator (PAM)
GAT229 is a positive allosteric modulator of the CB1 receptor, demonstrating significant potential in the reduction of intraocular pressure (IOP). Research indicates that GAT229 effectively enhances CB1 receptor-mediated IOP-lowering effects in high IOP mouse models. A solution of 0.2% GAT229 or administration at a dosage of 10 mg/kg results in notable IOP reduction, making it a valuable tool for studies focused on glaucoma and related conditions associated with elevated intraocular pressure. -
Phytocannabinoid Metabolite
6',7'-Epoxy cannabigerol is a phytocannabinoid metabolite that functions primarily as an active compound influencing cannabinoid receptor activity. This compound demonstrates potential biological activity associated with modulating neurotransmitter release and exhibiting anti-inflammatory properties. It is of particular interest in research applications focused on the therapeutic effects of cannabinoids and their mechanisms in various biological systems. -
Phytocannabinoid Derivative
11-Nor-9(R)-carboxy-hexahydrocannabinol is a phytocannabinoid derivative that interacts with the endocannabinoid system, specifically targeting cannabinoid receptors. This compound exhibits biological activity similar to other known cannabinoids, making it relevant for research into pain management, inflammation, and neuroprotection. It serves as a valuable tool for studies focused on the pharmacological effects of cannabinoids and their potential therapeutic applications. -
Cannabinoid Derivative
5-Fluoro PB-22 7-hydroxyquinoline isomer is a synthetic derivative of cannabinoids that selectively targets cannabinoid receptors. This compound exhibits notable biological activity by modulating receptor signaling pathways, making it valuable for research on cannabinoid receptor pharmacology. Its applications include studying the effects of cannabinoids on neuronal signaling and the exploration of therapeutic possibilities within the endocannabinoid system. -
Cannabinoid
MDMB-FUBINACA metabolite M1 is a synthetic cannabinoid that acts primarily on cannabinoid receptors. This metabolite exhibits significant affinity for CB1 and CB2 receptors, contributing to its biological activity in modulating cannabinoid signaling pathways. It serves as a valuable tool in research focused on the pharmacological effects of cannabinoids and the study of cannabinoid receptor interactions. -
Phytocannabinoid Derivative
Δ4(8)-iso-THC is a phytocannabinoid derivative that shares structural similarities with established cannabinoids. It interacts with cannabinoid receptors, exhibiting potential neuroprotective and anti-inflammatory properties. Research applications include studying the endocannabinoid system and exploring therapeutic avenues for neurological disorders and pain management. -
Cannabinoid Receptor Control
5Br-INACA is a synthetic cannabinoid precursor targeting cannabinoid receptors. It plays a crucial role in the production of cannabinoids for research applications involving the endocannabinoid system. Its use facilitates the exploration of cannabinoid receptor modulation and the investigation of related biological pathways. 5Br-INACA is valuable for studies aimed at understanding the pharmacological effects of cannabinoids in various biological contexts. -
Hexahydrocannabinol Metabolites
8(R)-Hydroxy-9(S)-Hexahydrocannabinol is a key metabolite of hexahydrocannabinol (HHC), interacting with cannabinoid receptors in the endocannabinoid system. This compound is of significant interest in pharmacological research for its potential therapeutic effects and metabolism of cannabinoids. It serves as a valuable tool in studying the pharmacokinetics and biological activity of HHC metabolites in various biological contexts. -
Phytocannabinoid Derivative
Dehydrocannabifuran is a phytocannabinoid derivative that interacts with cannabinoid receptors, primarily targeting the CB1 and CB2 receptors. This compound exhibits anti-inflammatory and analgesic properties, making it a valuable tool for research in pain management and inflammatory conditions. Its unique chemical structure and biological activities facilitate studies on cannabinoid mechanisms and therapeutic potential. -
Phytocannabinoid Derivative
11-Hydroxy-9(R)-hexahydrocannabinol is a phytocannabinoid derivative with notable affinity for cannabinoid receptors. This compound is primarily studied for its potential analgesic and anti-inflammatory properties, making it valuable in research focused on pain management and neuroprotection. Its metabolic pathways and interactions can provide insights into the therapeutic potential of cannabinoids in various biological systems. -
Phytocannabinoid
10α-Hydroxy-Δ8-THC is a phytocannabinoid that acts primarily on cannabinoid receptors. This compound demonstrates a range of biological activities, including potential analgesic and anti-inflammatory effects. It serves as a valuable tool for research in the fields of pharmacology and neuroscience, particularly in studies related to the therapeutic applications of cannabinoids. -
Phytocannabinoid Metabolite
11-Hydroxy-9(S)-hexahydrocannabinol is a phytocannabinoid metabolite known for its interaction with the endocannabinoid system. This compound exhibits significant biological activity, particularly in modulating cannabinoid receptors, which may influence various physiological processes such as pain perception, mood regulation, and appetite. It is primarily utilized in research related to cannabinoid pharmacology, therapeutic applications of cannabis, and the study of metabolic pathways of cannabinoids. -
CB1/CB2 Receptor Agonist
SAD448 is an agonist of the CB1 and CB2 receptors. It has demonstrated the ability to lower intraocular pressure (IOP), making it a valuable compound for research in ocular health and cannabinoid-mediated signaling pathways. This compound is relevant for studies investigating the therapeutic potential of cannabinoid receptor modulation in various conditions, including glaucoma and other diseases affecting intraocular pressure. -
A3AR Agonist
MRS5698 is a selective agonist of the A3 adenosine receptor (A3AR), effectively activating Gi protein signaling pathways. With Kis of approximately 3 nM for both human and mouse A3AR, this compound is valuable for investigating mechanisms related to pain and psoriasis. Its specificity may facilitate research into therapeutic applications targeting inflammatory and pain-related disorders. -
Adenosine A3 Receptor Modulator
VUF8507 is an allosteric modulator of the adenosine A3 receptor, demonstrating a binding affinity with a Ki of 204 nM. This compound enhances A3 receptor activity and has potential applications in the study of inflammatory diseases and neuroprotection. Researchers may utilize VUF8507 to gain insights into the modulation of adenosine signaling pathways and their implications in various biological processes. -
Adenosine Receptor Agonist
2-Chloro-3-deazaadenosine is an adenosine receptor agonist that demonstrates specific interactions with A1, A2A, A2B, and A3 receptors, exhibiting inhibitory constants (Kis) of 0.3, 0.08, 25.5, and 1.9 μM, respectively. This compound is valuable in the study of adenosine signaling pathways and its diverse biological effects, making it suitable for research applications involving receptor pharmacology and cell signaling. -
A2A Adenosine Receptor Antagonist
MSX-2 is a potent antagonist of the A2A adenosine receptor, exhibiting a Ki of 5 nM in human tissues. This compound plays a significant role in the modulation of physiological processes associated with Parkinson's disease. MSX-2 can be utilized in research aimed at understanding the therapeutic effects of A2A receptor inhibition in neurological disorders. -
Adenosine Receptor Inhibitor
CVT-2759 is a potent inhibitor of the A1 adenosine receptor, exhibiting IC50 values of 0.18 μM and 9.5 μM to antagonize [3H]CPX binding in the absence and presence of 1 mM GTP, respectively. This compound is essential for assessing the modulation of AV nodal conduction, facilitating a reduction in ventricular rate without inducing AV block, bradycardia, atrial arrhythmias, or vasodilation. It serves as a valuable reagent for research on cardiovascular physiology and pharmacological modulation of adenosine receptor pathways. -
A1 Adenosine Receptor Antagonist
(Rac)-WRC-0571 is a potent and selective antagonist of A1 adenosine receptors, characterized by its non-xanthine structure and oral bioavailability. It effectively inhibits the binding of [3H]-N6-cyclohexyladenosine (CHA) to guinea pig A1 receptors, demonstrating a Ki value of 1.1 nM. This compound is valuable for research into adenosine receptor signaling and its implications in various physiological and pathological processes. -
Adenosine A3 Receptor Antagonist
KF26777 (free base) is a highly selective antagonist of the adenosine A3 receptor, exhibiting a Ki value of 0.2 nM. It demonstrates significant selectivity over adenosine A1, A2A, and A2B receptors, with factors of 9000-fold, 2350-fold, and 3100-fold, respectively. This compound effectively inhibits [125I]AB-MECA binding to adenosine A3 receptors and holds potential for research into brain ischemia and inflammatory diseases, such as asthma. -
A3AR Ligand
I-AB-MECA is a selective ligand for the A3 adenosine receptor (A3AR), functioning as an important tool in receptor binding studies. This radioligand is utilized in various biological research applications, including pharmacological profiling and understanding adenosine receptor signaling pathways. It aids in elucidating the role of A3AR in various physiological and pathological processes. -
A1AR Agonist
(±)-5'-Chloro-5'-deoxy-ENBA is an A1 adenosine receptor (A1AR) agonist that induces hypothermia in murine models. This compound is instrumental in studying the physiological effects and therapeutic potential of A1AR modulation. It serves as a valuable tool for researchers investigating adenosine signaling pathways and their implications in various biological processes. -
Adenosine Receptor Antagonist
Xanthine amine congener trihydrochloride is a potent antagonist of adenosine A1 and A2 receptors, exhibiting IC50 values of 1.8 nM and 114 nM, respectively. This compound is utilized in research applications focusing on the modulation of adenosine receptors and elucidating their roles in various physiological and pathological processes. Additionally, Xanthine amine congener has been characterized as a convulsant agent in murine models, aiding in the study of seizure mechanisms. -
A1AR Antagonist
L-97-1 is a selective antagonist of the A1 adenosine receptor (A1AR). This water-soluble small molecule exhibits high affinity for human A1AR, effectively blocking receptor activation. By competitively inhibiting A1AR, L-97-1 alleviates adenosine-induced bronchoconstriction and inflammation, making it a valuable tool in asthma research and the study of airway hyperreactivity. Its action can contribute to a better understanding of therapeutic approaches for respiratory conditions associated with adenosine signaling. -
Adenosine Receptor Agonist
LUF5831 is a selective adenosine A1 receptor agonist with a binding affinity of Ki = 18 nM. It exhibits pharmacological activity by modulating adenosine signaling pathways, making it valuable for research applications investigating neurological processes and cardiovascular functions. Its unique properties facilitate studies on adenosine receptor-mediated effects in various biological systems. -
Adenosine Receptor Antagonist
Dansyl-NECA is a dansyl-labeled antagonist of adenosine receptors, functioning primarily through the inhibition of adenosine signaling pathways. This compound serves as a valuable tool in studying the biological effects of adenosine receptor modulation, providing insights into cellular mechanisms involved in neuroprotection, inflammation, and cancer research. Its fluorescence properties enhance detection and visualization in biochemical assays. -
A2AAR Antagonist
A2AAR antagonist 1 is a selective antagonist of the adenosine A2A receptor (A2AAR) with a Ki value of 20 nM. This compound exhibits high ligand efficiency and is suitable for research into neurodegenerative diseases, offering potential insights into therapeutic strategies targeting A2AAR-related pathways. Its pharmacological properties make it a valuable tool for elucidating receptor functions and investigating the role of adenosine signaling in various biological contexts. -
A1 AdoR Partial Agonist
CVT-2759 analog is a partial agonist of the A1 adenosine receptor, exhibiting a Ki value of 167 nM. This compound is valuable for research into cardiac arrhythmias, providing insights into the modulation of adenosine receptor signaling and its implications in cardiac health. Its specificity for the A1 receptor makes it a suitable tool for studying the physiological effects of adenosine in cardiac tissue. -
A2A Antagonist
LUF5981 is a potent antagonist of the adenosine A2A receptor, exhibiting a pIC50 value of 6.7. This compound has shown efficacy in modulating adenosine receptor activity, making it a valuable tool for research in areas such as neuroprotection, immunology, and cancer therapy. Its application in preclinical studies can aid in the exploration of A2A-mediated pathways and their role in various biological processes. -
A2B AdoR Antagonist
CVT-5440 is a selective antagonist of the A2B adenosine receptor, exhibiting high affinity with a Ki value of 50 nM. It demonstrates significant selectivity over other adenosine receptor subtypes, including A1, A2A, and A3, with selectivity ratios greater than 200. This compound is suitable for research applications focusing on asthma and related respiratory conditions, where modulation of adenosine signaling is of interest. -
Adenosine A3 Receptor Antagonist
MRS1067 is a competitive antagonist of the adenosine A3 receptor, effectively inhibiting the suppression of adenylate cyclase induced by adenosine A3 receptor agonists and influencing G protein activation. This compound is valuable in research applications focused on inflammation and cancer, providing insights into the role of adenosine A3 receptor signaling in various physiological and pathological processes. -
A2B Adenosine Receptor Antagonist
PSB-1115 potassium salt is a selective antagonist of the A2B adenosine receptor, demonstrating significant inhibitory effects on the receptor's activity. This compound is particularly notable for its ability to block the contraction inhibition of acetylcholine induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). It serves as a valuable tool for research into adenosine signaling pathways and the modulation of inflammation-related responses. -
Adenosine Receptor Binding Enhancer
PD81723 is an adenosine receptor binding enhancer that significantly boosts the inhibition of exogenous adenosine in a dose-dependent manner within hippocampal brain sections. This compound is vital for research exploring adenosine receptor modulation and its implications in neurological processes. Its ability to facilitate adenosine receptor interactions makes it an invaluable tool for studies focusing on cognitive function and related disorders. -
ADORA1 Modulator
ADORA1 modulator-1 is a selective modulator of the adenosine A1 receptor (ADORA1), known for its role in cellular signaling pathways. It demonstrates significant influence on neuroprotective and cardioprotective activities, making it valuable for the exploration of metabolic disorders and neurological diseases. This compound serves as a critical tool for researchers investigating the manipulation of adenosine receptor signaling in various biological contexts. -
A3AR Antagonist
A3AR Antagonist 5 is a selective antagonist of the human adenosine A3 receptor, demonstrating an affinity of pC 4.542 μM. This compound is valuable for research applications focused on investigating the role of A3 receptors in various physiological processes and pathological states. Its specificity may facilitate studies on adenosine-mediated signaling pathways and their implications in inflammation, cancer, and neuroprotection. -
A2AR Ligand
MNI-444 is a blood-brain barrier-permeable ligand for the adenosine A2A receptor (A2AR). This compound serves as a valuable tool in the investigation of non-dopaminergic pathways relevant to Parkinson's disease research. Its ability to selectively interact with A2AR positions it as a promising candidate for studying therapeutic strategies targeting neurodegenerative disorders. -
Adenosine A3 Antagonist
VUF8504 is a potent and selective antagonist of the adenosine A3 receptor, exhibiting a Ki value of 0.017 nM. This compound is primarily utilized in research focused on the modulation of adenosine signaling pathways, particularly in studies investigating the role of the A3 receptor in inflammation, neuroprotection, and cancer. Its high specificity makes VUF8504 a valuable tool for elucidating the biological functions of the A3 receptor in various physiological and pathological contexts. -
AdeR Agonist
N-(7H-Purin-6-yl)acetamide is a selective adenosine receptor (AdeR) agonist, exhibiting Ki values of 0.515 μM for the human adenosine receptor and 2.85 μM for the rat adenosine receptor. This compound has significant implications for research into adenosine receptor signaling pathways, pain mechanisms, inflammatory responses, and renal physiology. Its specificity for AdeR makes it a valuable tool for studying the role of adenosine in various biological processes. -
A2A Receptor Agonist
GW 328267 is an A2A receptor agonist that plays a pivotal role in modulating inflammatory responses. Its activation of the A2A receptor has potential applications in the study of asthma, chronic obstructive pulmonary disease (COPD), and upper respiratory inflammatory diseases. This compound serves as a valuable tool for researchers investigating the therapeutic implications of A2A receptor pathways in inflammatory conditions. -
Adenosine Receptor Antagonist
XCC is a 1,3,8-substituted xanthine derivative that functions as an adenosine receptor antagonist, exhibiting a Ki of 1.905 μM. This compound is valuable for studying adenosine receptor signaling pathways and their implications in various physiological processes and disease states. Research applications include pharmacological studies related to neuroprotection, inflammation, and cancer. -
Fluorinated Detergent
FLAC6 is a potent fluorinated detergent designed for the solubilization of membrane proteins, including the native adenosine receptor A2AR and two transporters, AcrB and BmrA. This reagent effectively preserves the structural and functional integrity of various membrane proteins, making it valuable for applications in structural biology and biophysical characterization. FLAC6 facilitates the study of GPCRs and transporters, enabling advancements in drug discovery and biochemical research. -
A2A Adenosine Receptor Agonist
2-Hexynyl-5′-N-ethylcarboxamidoadenosine is a selective agonist of the A2A adenosine receptor. It enhances intracellular cAMP levels and suppresses TNFα-induced MMP-3 release, indicating its anti-inflammatory potential. Furthermore, 2-Hexynyl-5′-N-ethylcarboxamidoadenosine promotes Aβ42 production in SH-SY5Y cells, making it a valuable tool for research on neurodegenerative diseases and receptor signaling pathways. -
Adenosine A2A Antagonist
ST4206 is a potent adenosine A2A receptor antagonist, exhibiting inhibitory constants (Kis) of 12 nM for the A2A receptor and 197 nM for the A1 receptor. This compound demonstrates significant biological activity, making it a valuable tool in the study of neurodegenerative disorders. ST4206 holds potential for advancing research in Parkinson's disease, providing insights into adenosine-mediated signaling pathways. -
Adenosine Receptor Antagonist
A2B receptor antagonist 1 is a selective antagonist of the A2B adenosine receptor. This compound demonstrates significant inhibition of adenosine-mediated signaling pathways, making it valuable in the investigation of adenosine receptor functions and their roles in various physiological and pathological conditions. A2B receptor antagonist 1 is applicable in research areas such as immunology, cancer biology, and neurobiology. -
Adenosine Receptor Antagonist
Sch412348 is a highly potent competitive antagonist of the human adenosine A2A receptor, exhibiting a Ki value of 0.6 nM and demonstrating over 1000-fold selectivity against other adenosine receptor subtypes. This selectivity makes Sch412348 a valuable tool for studying adenosine signaling pathways. It is particularly relevant in research focusing on neurological disorders, cardiovascular conditions, and cancer, where modulation of adenosine receptors may provide therapeutic insights. -
Adenosine Receptor Inhibitor
KF21213 is a selective adenosine A2A receptor inhibitor, demonstrating a high affinity with a Ki value of 3.0 nM. This compound is essential for research involving central nervous system (CNS) functions and disorders, providing valuable insights into adenosine receptor signaling pathways. Its precision in targeting A2A receptors makes it a suitable tool for studying their role in neuropharmacology and related therapeutic applications. -
Adenosine Receptor Agonist
UP202-56 is an adenosine receptor agonist that selectively activates adenosinergic signaling pathways. Its primary mechanism involves mimicking endogenous adenosine, leading to enhanced receptor-mediated cellular responses. This compound is essential for research applications focused on exploring adenosine-related physiological processes and the potential therapeutic implications in various diseases. -
Adenosine Receptor Antagonist
N-0861 racemate is a selective antagonist of the adenosine A1 receptor. It exhibits notable activity in modulating adenosine signaling pathways, making it valuable for research in neurology and cardiology. This compound is essential for investigating the physiological roles of adenosine receptors and their implications in various biological processes.
