Catalog No.
Product Name
Application
Product Information
Citations
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OX Receptor Antagonist
MK-8133 is a selective orexin-2 receptor antagonist that inhibits orexin signaling pathways. It has demonstrated efficacy in the modulation of sleep-wake cycles, making it a valuable tool for researching insomnia and other sleep disorders. This compound can be utilized in various experimental models to investigate the role of orexin in sleep regulation and potential therapeutic interventions. -
Antioxidant
Ethoxyquin dimer is a dimeric form of the compound Ethoxyquin, functioning primarily as an antioxidant. This compound demonstrates enhanced accumulation in liver and adipose tissues relative to its monomer counterpart. Research indicates that concentrations exceeding 10 mg/kg can lead to hepatotoxicity in mice, making it a significant consideration in studies of oxidative stress and tissue-specific accumulation. -
Oxytocin Receptor Agonist
LIT-001 is a selective nonpeptide agonist of the oxytocin receptor, exhibiting an EC50 of 55 nM and a Ki of 226 nM. This compound has demonstrated the ability to enhance social interaction in preclinical mouse models of autism, making it a valuable tool for research into social behavior modulation and potential therapeutic applications in neurodevelopmental disorders. LIT-001 provides a unique avenue for exploring the role of oxytocin signaling in various neurobiological contexts. -
Oxytocin Receptor Antagonist
Erlosiban is a potent oxytocin receptor antagonist that exhibits oral bioactivity. By inhibiting the increase in intracellular calcium concentration, Erlosiban effectively reduces uterine smooth muscle contraction. This compound is primarily utilized in research related to premature birth and enhancing embryo implantation and pregnancy rates in assisted reproductive technologies. -
Oxytocin Receptor Agonist
Merotocin is a selective agonist of the oxytocin receptor, known for its short-acting properties. This peptidic compound primarily enhances lactation by promoting milk ejection through stimulation of the mammary glands. Merotocin is utilized in research aimed at understanding lactation dynamics and the physiological roles of oxytocin in reproductive biology. -
Oxytocin Receptor Antagonist
L-367773 is a selective antagonist of the oxytocin receptor, demonstrating Ki values of 26 nM for the rat uterine oxytocin receptor and 61 nM for the human uterine oxytocin receptor. This compound effectively inhibits oxytocin-stimulated uterine contractions, making it a valuable tool for research related to reproductive biology and uterine physiology. Its oral bioactivity further enhances its utility in pharmacological studies. -
Oxytocin Receptor Agonist
Carbetocin acetate is an oxytocin receptor agonist known for its high affinity with a Ki of 7.1 nM. This compound binds effectively to the chimeric N-terminus of the oxytocin receptor with a Ki of 1.17 μM. Carbetocin acetate holds potential for applications in postpartum hemorrhage research and is capable of crossing the blood-brain barrier, demonstrating antidepressant-like effects through the activation of central nervous system oxytocin receptors. -
Tocolytic Agent
5β-Dihydroprogesterone (5βDHP) is a metabolite of Progesterone that functions as a tocolytic agent. It exerts its biological activity by binding to the oxytocin receptor, subsequently diminishing oxytocin-induced calcium signaling. This property positions 5βDHP as a valuable reagent for research in obstetrics and reproductive biology, particularly in studies focused on the modulation of uterine contractions. -
Oxytocin Derivative
[Glu4]-Oxytocin is a synthetic derivative of oxytocin designed to facilitate the study of the conformational properties of "oxytocin-like" peptides in aqueous environments. This compound retains the biological activity of oxytocin, making it suitable for research applications in neurobiology and endocrinology. Its unique structure allows for enhanced investigation into the interactions and mechanisms of oxytocin-related signaling pathways. -
Oxytocin Receptor (OTR) Agonist
WAY-267464 is a non-peptide agonist targeting the oxytocin receptor (OTR). It has been shown to impair social recognition memory in rat models, likely through its antagonistic action on the vasopressin 1A receptor. This compound is relevant for research into psychiatric disorders, including autism spectrum disorder, schizophrenia, and social anxiety disorder. -
Oxytocin Antagonist
L-372662 is a potent, orally active non-peptide antagonist of the oxytocin receptor (OTR). It has a Ki value of 4.8 nM and demonstrates high affinity with Kd values of 5.8 nM for wild-type OTR and 73 nM for the [A318G] variant. This compound exhibits selectivity for OTR over the vasopressin 1a receptor (V1aR), making it a valuable tool in research applications related to neuroendocrine regulation and social behavior. -
OXTR Agonist
TC OT 39 is a synthetic analog of oxytocin and a selective agonist of the oxytocin receptor (OXTR), demonstrating an EC50 value of 180 nM. This compound also acts as an Avprla vasopressin receptor antagonist with a Ki value of 330 nM. TC OT 39 is noted for its sedative effects in mouse models, making it a valuable tool for research into neuropsychological and behavioral studies involving the oxytocin system. -
Vasoconstrictor Agent
[Arg8]-Vasotocin is a neurohypophyseal peptide that functions as a potent vasoconstrictor agent. This compound mimics the structure of vasopressin, enhancing its biological activity in regulating vascular tone and blood pressure. It is widely used in research to study cardiovascular physiology, neuroendocrine signaling, and the role of vasopressin-related peptides in various biological processes. -
Oxytocin Analogue
[Leu3]-Oxytocin is an oxytocin analogue characterized by a substitution of leucine at the third position of the peptide sequence. This modification enhances its binding affinity to oxytocin receptors. [Leu3]-Oxytocin is utilized in research to investigate various physiological processes, including social bonding, stress response, and reproductive behaviors, making it a valuable tool for studying neuropeptide signaling pathways. -
OXT ligand
Pro8-Oxytocin is a modified oxytocin (OXT) ligand that exhibits enhanced potency and efficacy at primate oxytocin receptors (OXTR) compared to Leu8-Oxytocin. This compound demonstrates significantly stronger behavioral effects, making it a valuable tool in neuropharmacology research. Additionally, Pro8-Oxytocin shows a lower efficacy than vasopressin at human AVPR1a receptors while producing a higher efficacy at marmoset AVPR1a receptors, positioning it as an important reagent for studying receptor specificity and ligand-receptor interactions. -
Oxytocin Receptor Agonist
WAY-267464 hydrochloride is a non-peptide agonist of the oxytocin receptor. This compound has demonstrated the ability to impair social recognition memory in rats, likely through its action as a vasopressin 1A receptor antagonist. WAY-267464 hydrochloride is valuable for researching psychiatric disorders, including autism spectrum disorder, schizophrenia, and social anxiety disorder. -
Isomer
(S)-Retosiban is an isomer of Retosiban, serving as a valuable experimental control in research. As a selective oxytocin antagonist, it exhibits potent binding affinity with a Ki value of 0.65 nM. This compound is applicable in studies investigating the role of oxytocin in various physiological and pathological processes, contributing to advancements in understanding its biological activities. -
Oxytocin Analog
Demoxytocin is a cyclic peptide analog of oxytocin, primarily targeting oxytocin receptors. It enhances cell membrane permeability and elevates intracellular calcium levels in smooth muscle cells, resulting in increased contraction. This compound is particularly valuable for investigating the role of labor stimulation in conditions such as preterm premature rupture of membranes, as it mimics the biological activity of oxytocin in promoting uterine smooth muscle contraction. -
Antidiabetic Agent
[Asu1,6]-Oxytocin is an analog of oxytocin, functioning as an antidiabetic agent. It has been shown to reverse insulin resistance and improve glucose intolerance, independent of weight loss. This compound is valuable for research into obesity and diabetes, particularly in understanding mechanisms that contribute to metabolic regulation. -
Oxytocin Receptor Antagonist
L 366509 is a spiroindenylpiperidine camphorsulfonamide that acts as an antagonist of the oxytocin receptor. It demonstrates high affinity and selectivity for oxytocin receptors, making it a valuable tool in studies investigating oxytocin's physiological roles. This compound is particularly relevant for research into uterine contractions and has shown efficacy in inhibiting oxytocin-stimulated contractions, showcasing its potential applications in reproductive health. Additionally, molecular modeling indicates that its structure effectively mimics critical elements found in potent oxytocin antagonists. -
Oxytocin Analogue
Cargutocin, an oxytocin analogue, selectively targets the oxytocin receptor, facilitating uterine contractions. This compound enhances understanding of reproductive biology and assists in exploring therapeutic avenues for obstetric conditions. Its applications in research include studying labor induction and modulation of social behaviors linked to oxytocin signaling. -
OT-R Antagonist
Barusiban is a potent oxytocin receptor (OT-R) antagonist with a Ki of 0.8 nM, effectively inhibiting oxytocin-induced contractions. This compound is valuable for research applications in preterm labor, in vitro fertilization, and infertility studies. Its ability to modulate OT-R activity provides insights into reproductive health and physiological processes related to labor. -
Oxytocin Antagonist
L-366682 is a cyclic hexapeptide that acts as an oxytocin antagonist. It is primarily involved in research applications focused on the modulation of oxytocin-related physiological processes, including social behavior, stress response, and reproductive functions. This compound is valuable for studies investigating the effects of oxytocin signaling and its implications in various neuroendocrine conditions. -
0xytocin Antagonist Analog
OT Antagonist 3 Analog is an analog of the oxytocin receptor antagonist. This compound exhibits inhibitory activity on oxytocin signaling, making it a valuable tool for research into the modulation of social behaviors, reproductive functions, and stress responses. Its application spans therapeutic exploration in conditions associated with oxytocin dysregulation, providing insights into neuroendocrine pathways and potential pharmacological interventions. -
OT Receptor Antagonist
L-368,899 is a selective antagonist of the oxytocin (OT) receptor, exhibiting IC50 values of 8.9 nM and 26 nM in rat and human uterine tissues, respectively. This orally active compound effectively crosses the blood-brain barrier and is proven to inhibit oxytocin-stimulated uterine contractions in rat models. L-368,899 is valuable for research into preterm labor and the physiological roles of oxytocin in reproductive biology. -
Oxytocin Receptor Agonist
LIT-001 free base is a selective oxytocin receptor agonist, exhibiting an EC50 of 55 nM and a Ki of 226 nM. This compound has demonstrated significant enhancement of social interaction behaviors in mouse models of autism, making it a valuable tool for research in neuropsychiatric disorders and social behavior. Its nonpeptide structure distinguishes it as a lead candidate for further investigation into therapeutic applications related to oxytocin signaling. -
Gq-Dependent Pathway Agonist
(Val3,Pro8)-Oxytocin is a Gq-dependent pathway agonist that selectively activates the oxytocin receptor (OXTR). This compound demonstrates potential biological activity by engaging β-arrestin and promoting endocytosis, albeit at a weaker efficacy compared to its primary action. It is valuable for research applications targeting neurobiology, reproductive health, and cardiovascular studies, facilitating insights into therapeutic mechanisms involving the oxytocin signaling pathway. -
Oxytocin Analog
Oxytocin free acid, also known as 9-Deamidooxytocin, is an analog of oxytocin characterized by the substitution of the glycinamide residue at position 9 with a glycine residue. This peptide hormone exhibits diverse biological activities, influencing various physiological processes such as reproductive functions, social behaviors, and stress responses. Oxytocin free acid serves as an important tool in research exploring the mechanisms of action of oxytocin and its potential therapeutic applications in neurobiology and endocrinology. -
Oxytocin Receptor Antagonist
L 156373 is a potent antagonist of the oxytocin receptor, exhibiting an inhibitory constant (Ki) of 150 nM. This compound is valuable for studies investigating the physiological and pathophysiological roles of oxytocin, making it applicable in research areas such as neurobiology, endocrinology, and reproductive health. Its ability to selectively inhibit oxytocin receptor activity facilitates exploration of its implications in social behaviors, stress response, and various clinical conditions. -
Oxytocin Receptor Antagonist
SSR126768A free base is a potent oxytocin receptor antagonist with a Ki of 0.44 nM. This compound acts as a tocolytic agent by inhibiting oxytocin-induced intracellular calcium signaling and prostaglandin release in human uterine smooth muscle cells. As a result, SSR126768A effectively inhibits oxytocin-induced uterine contractions and has been shown to delay parturition in pregnant rats experiencing labor. This reagent is valuable for research applications focused on reproductive biology and the modulation of uterine contractility. -
Oxytocin Antagonist
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin serves as an oxytocin antagonist, inhibiting the effects of oxytocin on its receptor. This compound shows potential in the study of sexual behavior and related neurobiological processes. Its application in research may further elucidate the role of oxytocin in social and reproductive behaviors. -
OT Antagonist Demethyl Derivative
OT Antagonist 1 Demethyl Derivative functions as a selective antagonist of the oxytocin receptor, exhibiting a Ki value of 50 nM. This compound demonstrates significant inhibitory activity, making it suitable for research focused on oxytocin signaling pathways and its physiological roles. It can be utilized in studies investigating the modulation of social behaviors, reproductive functions, and stress responses linked to oxytocin. -
Oxytocin Receptor
Epelsiban besylate is a selective antagonist of the oxytocin receptor, offering potential in the modulation of oxytocin-related pathways. This compound has been shown to influence various biological activities, including social behavior and reproductive functions. It is primarily utilized in research exploring the effects of oxytocin signaling in neuropsychiatric disorders and other related fields. -
Oxytocin Receptor
ALS-I-41 is a potent and selective antagonist of the oxytocin receptor, which plays a crucial role in regulating social behavior and various mental disorders. This compound demonstrates significant potential for use in behavioral pharmacology studies, particularly in non-human primates. Its administration can be performed via intranasal or intramuscular routes, and its pharmacokinetics, including central nervous system penetration and metabolic rate, have been thoroughly assessed using mass spectrometry in the cerebrospinal fluid and plasma of macaque monkeys. -
Oxytocin/Vasopressin V1a-Receptor Agonist
Kalata B7 is a cyclotide that selectively targets the oxytocin and vasopressin V1a receptors as a partial agonist. Its unique cyclic structure enables it to penetrate cell membranes effectively, facilitating its biological activity. This reagent is primarily utilized in research applications focusing on the modulation of receptor signaling pathways associated with social behavior, stress responses, and cardiovascular functions. -
Oxytocin Receptor Antagonist
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin is an oxytocin receptor antagonist that effectively inhibits oxytocin-induced enhancement of inhibitory postsynaptic currents in CA1 pyramidal neurons. This compound is valuable for investigating the role of oxytocin in synaptic transmission and neuronal regulation. Researchers can utilize this reagent to explore its potential implications in neurobiology and associated therapeutic applications. -
Mixture Of E/Z Forms Of OT-R Antagonist 1
(E/Z)-OT-R antagonist 1 is a mixture of E and Z isomers that functions as a selective, non-peptide antagonist of the oxytocin receptor (OT-R). This compound effectively inhibits oxytocin-induced intracellular calcium activation, exhibiting an IC50 value of 8 nM. Its potent antagonistic activity makes it a valuable tool for investigating the role of oxytocin signaling in various biological processes and pathological conditions. Researchers can utilize this reagent in studies related to neurobiology, reproductive health, and stress response mechanisms. -
Oxytocin/Arginine Vasopressin Antagonist
L-364918 is a selective antagonist of oxytocin and arginine vasopressin, exhibiting Ki values of 30 nM for oxytocin, 1300 nM for AVP-V1, and 2400 nM for AVP-V2. This compound may be beneficial for research focused on preterm labor and conditions related to water balance dysregulation. Its pharmacological profile supports investigations into the role of these neuropeptides in various physiological and pathological processes. -
Oxytocin Receptor Agonist
OT-R Agonist 1 TFA is a potent oxytocin receptor agonist with an EC50 value of 0.39 nM, making it an excellent tool for investigating oxytocin signaling pathways. Additionally, this compound exhibits V1A antagonist activity with an EC50 of 2432 nM. It is primarily utilized in research related to central nervous system disorders, providing insights into neurobiology and potential therapeutic approaches. -
Oxytocin Antagonist
L-365209 is an oxytocin antagonist that selectively inhibits the binding of oxytocin to its receptors. Its primary mechanism involves blocking the physiological effects mediated by oxytocin, which is critical in processes such as social behavior, reproduction, and stress responses. This compound is valuable for research applications investigating the role of oxytocin in various physiological and pathological conditions. -
OXTR Modulator
OXTR modulator-1 is an oxytocin receptor (OXTR) modulator that selectively influences OXTR activity. This compound exhibits potential biological activity in enhancing social behavior and emotional processing, making it a valuable tool for research into neuropsychiatric disorders and social cognition. Its applications extend to studies investigating the physiological and therapeutic roles of oxytocin in various animal models. -
OXTR Modulator
OXTR modulator-2 is a selective modulator of the oxytocin receptor (OXTR), influencing pathways associated with social behavior and emotional responses. This compound enhances OXTR activity, making it instrumental in research on neuropsychiatric disorders, stress resilience, and social cognition. Its application extends to investigating the role of oxytocin in various biological processes, enabling insights into therapeutic strategies targeting mood and anxiety disorders. -
RFamide Neuropeptide
Neuropeptide AF (cattle) is an amidated octadecapeptide that targets RFamide neuropeptide receptors. It serves as a ligand for Mas-related gene receptor A4 (MrgprA4) with an EC50 of approximately 60 nM and MrgprC11 with an EC50 around 300 nM. Additionally, it activates the G protein-coupled receptors NPFF1 and NPFF2, exhibiting EC50 values ranging from 25-325 nM and 1-5 nM, respectively. Neuropeptide AF (cattle) demonstrates anti-opiate properties and plays a significant role in pain modulation research applications. -
MCHR1 Antagonist
SNAP 94847 hydrochloride is a selective antagonist targeting the melanin-concentrating hormone receptor 1 (MCHR1), exhibiting high affinity with a Ki value of 2.2 nM and Kd value of 530 pM. This compound demonstrates significant selectivity, showing over 80-fold and over 500-fold preference for MCHR1 over MCHα1A and MCHD2 receptors, respectively. SNAP 94847 hydrochloride binds effectively to MCHR1 in both mouse and rat models, displaying minimal cross-reactivity with other GPCRs, ion channels, enzymes, and transporters. Its properties make it a valuable tool for studying MCHR1-related biological processes and potential therapeutic applications. -
Melanogenesis Inhibitor
Ethyl linolenate is a fatty acid ethyl ester that functions as a melanogenesis inhibitor. It effectively reduces melanin production in cells, exhibiting an IC50 of 70 μM. This compound is valuable in research applications focused on skin pigmentation and related disorders, as well as in the exploration of potential therapeutic agents for hyperpigmentation conditions. -
MCH Receptor 1 Antagonist
BI 186908 is a selective and orally active antagonist of the melanin-concentrating hormone (MCH) receptor 1, demonstrating an IC50 of 22 nM and a Ki of 14 nM. This compound exhibits high affinity for recombinant MCH-R1 across several species, including human, cynomolgus monkey, dog, and rat, with IC50 values ranging from 18 nM to 23 nM. BI 186908 has been shown to significantly reduce body weight in diet-induced obese rat models, making it a valuable tool for research in obesity and related metabolic disorders. -
MCH1 receptor Antagonist
RGH-706 is a selective MCH1 receptor antagonist with an IC50 of 6.2 nM against human MCHR1, demonstrating oral bioavailability and the ability to cross the blood-brain barrier. This compound is primarily utilized in research focused on obesity and Prader-Willi syndrome, as it effectively improves obesity-related outcomes without antagonizing hMCH2 receptors. RGH-706 serves as a valuable tool for studying mechanisms of appetite regulation and metabolic disorders. -
MCHR-1 Antagonist
BMS-830216 is a potent antagonist of the melanin-concentrating hormone receptor 1 (MCHR-1). As a phosphate ester prodrug, it exhibits effective conversion to its active form in biological systems. This compound is primarily utilized in obesity-related research, providing insights into the role of MCHR-1 in energy homeostasis and potential therapeutic strategies for weight management. -
MCH R1 Antagonist
GW-803430 is a potent and selective antagonist of the melanin-concentrating hormone receptor 1 (MCH R1), exhibiting a pIC50 of 9.3. This compound demonstrates significant biological activity by inhibiting MCH R1, which plays a critical role in regulating energy balance and appetite. GW-803430 is primarily utilized in research applications focusing on obesity and metabolic disorders, providing insight into the therapeutic potential for weight management strategies. -
MCH1R Antagonist
ATC0175 is a potent and selective antagonist of the melanin-concentrating hormone 1 receptor (MCH1R) with an IC50 of 13.5 nM, exhibiting minimal effect on MCH2R (IC50 > 10,000 nM). This compound demonstrates significant antidepressant and anxiolytic activity in various animal models. ATC0175 serves as a valuable tool for investigating the mechanisms underlying depression and anxiety disorders in preclinical research.
