ATC0175 is a potent and selective antagonist of the melanin-concentrating hormone 1 receptor (MCH1R) with an IC50 of 13.5 nM, exhibiting minimal effect on MCH2R (IC50 > 10,000 nM). This compound demonstrates significant antidepressant and anxiolytic activity in various animal models. ATC0175 serves as a valuable tool for investigating the mechanisms underlying depression and anxiety disorders in preclinical research.
ATC0175 is a potent and selective antagonist of the melanin-concentrating hormone 1 receptor (MCH1R) with an IC50 of 13.5 nM, exhibiting minimal effect on MCH2R (IC50 > 10,000 nM). This compound demonstrates significant antidepressant and anxiolytic activity in various animal models. ATC0175 serves as a valuable tool for investigating the mechanisms underlying depression and anxiety disorders in preclinical research.
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