SNAP 94847 hydrochloride is a selective antagonist targeting the melanin-concentrating hormone receptor 1 (MCHR1), exhibiting high affinity with a Ki value of 2.2 nM and Kd value of 530 pM. This compound demonstrates significant selectivity, showing over 80-fold and over 500-fold preference for MCHR1 over MCHα1A and MCHD2 receptors, respectively. SNAP 94847 hydrochloride binds effectively to MCHR1 in both mouse and rat models, displaying minimal cross-reactivity with other GPCRs, ion channels, enzymes, and transporters. Its properties make it a valuable tool for studying MCHR1-related biological processes and potential therapeutic applications.
SNAP 94847 hydrochloride is a selective antagonist targeting the melanin-concentrating hormone receptor 1 (MCHR1), exhibiting high affinity with a Ki value of 2.2 nM and Kd value of 530 pM. This compound demonstrates significant selectivity, showing over 80-fold and over 500-fold preference for MCHR1 over MCHα1A and MCHD2 receptors, respectively. SNAP 94847 hydrochloride binds effectively to MCHR1 in both mouse and rat models, displaying minimal cross-reactivity with other GPCRs, ion channels, enzymes, and transporters. Its properties make it a valuable tool for studying MCHR1-related biological processes and potential therapeutic applications.
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