Catalog No.
Product Name
Application
Product Information
Citations
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RIPK1 Inhibitor
AV123 is a potent RIPK1 inhibitor with an IC50 of 12.12 µM. This non-cytotoxic compound effectively blocks TNF-α-induced necroptosis, exhibiting an EC50 of 1.7 µM, while leaving apoptotic pathways unaffected. AV123 is valuable for investigating necrotic conditions, including ischemia-reperfusion injuries in the brain, heart, and kidney, as well as in various inflammatory and neurodegenerative diseases. -
RIPK1 Inhibitor
Oditrasertib is a selective reversible inhibitor of receptor-interacting protein kinase 1 (RIPK1), demonstrating oral bioavailability and the ability to penetrate the blood-brain barrier. It is primarily utilized in research related to chronic inflammatory diseases of the central nervous system, including amyotrophic lateral sclerosis and multiple sclerosis. Oditrasertib provides valuable insights into the mechanisms of RIPK1-mediated signaling pathways, aiding in the development of potential therapeutic strategies for these conditions. -
RIPK1 Inhibitor
Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an IC50 of 0.0375 µM. This compound is crucial for studying signaling pathways related to inflammation and cell death, making it valuable for research applications in apoptosis, neurodegeneration, and autoimmune diseases. Eclitasertib provides an effective tool for elucidating the role of RIPK1 in various biological contexts. -
RIPK3 Inhibitor
UH15-38 is a potent inhibitor of receptor-interacting protein kinase 3 (RIPK3), exhibiting an IC50 of 20 nM. This compound effectively blocks necroptosis activated by influenza A virus (IAV), reducing associated cellular damage. UH15-38 is valuable for research aimed at understanding viral pathogenesis and investigating potential therapeutic approaches for IAV-induced lung injury. -
RIPK3 Inhibitor
GSK840 is a highly potent inhibitor of receptor-interacting protein kinase 3 (RIPK3), exhibiting an IC50 of 0.9 nM for binding to the RIP3 kinase domain and an IC50 of 0.3 nM for inhibiting its kinase activity. This compound provides a valuable tool for studying RIPK3-mediated pathways and their role in programmed cell death and inflammation. GSK840 is applicable in research focused on neurodegenerative diseases, cancer, and immune responses. -
RIPK1/RIPK3 Inhibitor
RIPK1-IN-17 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1) with a Kd of 17 nM, exhibiting minimal activity against RIPK3. This compound specifically targets necroptosis by inhibiting the phosphorylation of RIPK1, RIPK3, and MLKL, thereby preventing necroptotic cell death while allowing apoptosis to proceed. RIPK1-IN-17 has demonstrated protective effects in mice against hypothermia and mortality, making it a valuable tool for researching necroptosis-related conditions, particularly in the context of inflammatory response syndrome (SIRS). -
RIPK2 Modulator
cRIPGBM chloride is a selective modulator of receptor-interacting protein kinase 2 (RIPK2) that induces caspase 1-dependent apoptosis. This compound effectively disrupts the RIPK2/TAK1 prosurvival complex while promoting the formation of the RIPK2/caspase 1 pro-apoptotic complex. cRIPGBM chloride demonstrates significant anti-tumor efficacy in vivo in animal models, making it a valuable tool for research into glioblastoma multiforme (GBM) and related cancer therapies. Its proapoptotic properties offer insights into mechanisms of cell death and potential therapeutic strategies in cancer treatment. -
RIPK1 Inhibitor
Zharp1-211 is a selective inhibitor of RIPK1 kinase, with an EC50 of 53 nM and a Kd of 8.7 nM. This compound effectively reduces IFN-γ-induced STAT1 activation, presenting significant implications for the study of inflammatory responses. Zharp1-211 is suitable for research applications related to graft-versus-host disease and colon cancer, contributing to investigations into therapeutic strategies for these conditions. -
RIPK1 PROTAC Degrader
LD4172 is a selective RIPK1 PROTAC degrader that exhibits a Ki of 4.8 nM. It facilitates RIPK1 protein degradation through the formation of a ternary complex with RIPK1 and VHL E3 ligase, leading to ubiquitination and proteasomal degradation. LD4172 effectively inhibits TNF-induced classical NF-κB signaling in TRAF2-deficient cells, significantly reducing IκBα phosphorylation and IL-8 production. Additionally, it promotes apoptosis and immunogenic cell death in tumor cells, enhances tumor-infiltrating lymphocyte responses, and sensitizes tumors to anti-PD1 therapy, making it a valuable chemical probe for studying RIPK1-related functions in melanoma and colon cancer research. -
RIPK2 Inhibitor
Zharp2-1 is a potent inhibitor of receptor-interacting protein kinase 2 (RIPK2), which plays a critical role in inflammatory responses. This compound is particularly relevant in the context of inflammatory bowel disease (IBD), demonstrating the ability to modulate immune cell activation in response to muramyl dipeptide (MDP). Zharp2-1 effectively reduces MDP-induced small inguinal peritonitis and alleviates inflammation associated with DNBS-induced large inguinal conjunctivitis, making it a valuable tool for research in models of chronic inflammation and IBD. -
Caspase Inhibitor
Z-VA-DL-D-FMK is an irreversible caspase inhibitor that targets and binds to caspases, modulating their activity. This compound enhances the sensitivity of TNF-α, thereby influencing apoptotic pathways. Additionally, Z-VA-DL-D-FMK has been shown to activate HIV replication in infected T cells, such as ACH-2, making it valuable for studies in cell signaling and viral reactivation. -
Caspase-1 Inhibitor
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1, a key enzyme involved in inflammatory processes and programmed cell death. This compound demonstrates significant antitumor activity by modulating inflammatory responses and apoptosis. It is suitable for research applications focused on understanding caspase-1's role in cancer biology and related inflammatory diseases. -
Caspase 2 siRNA
Cosdosiran is a chemically modified small interfering RNA (siRNA) that specifically targets and inhibits the expression of caspase 2 protein. This reagent is instrumental in researching nonarteritic anterior ischemic optic neuropathy and various optic neuropathies, including glaucoma, that lead to the degeneration of retinal ganglion cells. Cosdosiran facilitates the exploration of pathways involved in retinal cell survival and offers insights into potential therapeutic strategies for neurodegenerative eye diseases. -
Caspase Inhibitor
Ac-VEID-CHO is a potent peptide-derived caspase inhibitor that targets Caspase-3, Caspase-6, and Caspase-7, displaying IC50 values of 13.6 nM, 16.2 nM, and 162.1 nM, respectively. Additionally, it inhibits VEIDase activity with an IC50 of 0.49 µM. This compound is valuable for research into neurodegenerative diseases, including Alzheimer’s and Huntington’s disease, facilitating the study of apoptotic pathways and potential therapeutic interventions. -
Apoptosis Inducer
Dimethyl tetrasulfide (1,4-Dimethyltetrasulfane) is an apoptosis inducer that specifically targets leukemia cells. It demonstrates cytotoxic effects by promoting the production of intracellular reactive oxygen species (ROS) and activating the caspase-3 enzyme. This compound is valuable for research into cancer therapies, particularly in the context of leukemia. -
Caspase-1 Inhibitor
Ac-Trp-Glu-His-Asp-Aldehyde is a selective inhibitor of caspase-1, demonstrating a remarkable Ki value of 56 pM. This compound plays a crucial role in the modulation of inflammatory processes by inhibiting the activation of caspase-1, an essential enzyme in the maturation of pro-inflammatory cytokines. It is widely utilized in research focused on innate immunity, inflammation, and therapeutic approaches for diseases driven by caspase-1 activity. -
Caspase Inhibitor
Ac-VAD-CMK is a pan-caspase inhibitor that effectively targets and inhibits various caspases, including caspases 1, 3, and 7. This compound is utilized in research to study apoptotic pathways and cell death mechanisms. Its application extends to investigating inflammation and neurodegenerative diseases where caspase activity is a critical factor. -
Caspase 4/5/9 Inhibitor
Ac-AAVALLPAVLLALLAP-LEHD-CHO is a potent inhibitor of caspases 4, 5, and 9. This compound demonstrates protective effects in MCF-7 cells treated with Neocarzinostatin, highlighting its potential applications in apoptosis research and cell survival studies. Its ability to modulate caspase activity makes it a valuable tool for investigating pathways related to cell death and disease mechanisms. -
Caspase-2/3 Inhibitor
Ac-VDVAD-CHO is a potent inhibitor of caspase-2 and caspase-3, with IC50 values of 46 nM and 15 nM, respectively. This compound effectively interferes with apoptotic signaling pathways, making it a valuable tool for research into cell death mechanisms. It is suitable for applications involving the study of apoptosis, neurodegeneration, and cancer. -
Caspase Inhibitor
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor that specifically targets and inhibits caspase activity. This compound effectively prevents the dissipation of mitochondrial membrane potential (MMP) and the release of cytochrome c in cells exposed to hypoxic conditions. Ac-VAD-CHO is widely used in research applications aimed at studying apoptosis and cell survival mechanisms. -
Caspase-3 Substrate
Ac-LEVDGWK(Dnp)-NH2 is a synthetic substrate for Caspase-3, designed to facilitate the measurement of Caspase-3 enzymatic activity. Its use in research enables the study of apoptosis and cellular signaling pathways, providing insights into the role of Caspase-3 in various biological processes. This substrate can be employed in assays to quantify Caspase-3 activity in different biological samples. -
Caspase-9 Substrate
Z-VAD-AMC is a potent substrate for caspase-9, facilitating the study of apoptosis mechanisms. It exhibits high specificity for this caspase, enabling accurate monitoring of caspase activity in cellular assays. Researchers commonly utilize Z-VAD-AMC in studies focusing on programmed cell death, cellular stress responses, and therapeutic interventions targeting apoptotic pathways. -
Caspase Inhibitor
Ac-LEHD-CHO is a selective inhibitor of caspase-8 and caspase-9. It effectively blocks apoptosis in hepatocytes and prevents hepatotoxicity induced by GalN/TNF-α. This compound is valuable for research applications involving cell death pathways and liver-related diseases. -
Apoptosis Inducer
9-cis-Canthaxanthin is a carotenoid recognized for its pro-apoptotic properties, particularly in THP-1 macrophage cells. This compound induces apoptosis by enhancing the activity of caspase-3 and caspase-8, making it a valuable tool for studying apoptosis pathways and cellular responses in various research applications. -
Caspase Substrate
(Asp)2-Rhodamine 110 is a fluorescent substrate specifically designed for caspase activity detection. This compound is cleaved by active caspases, resulting in the release of a fluorescent signal that allows for real-time monitoring of apoptosis in various biological systems. It is widely utilized in research applications focused on cell death mechanisms and therapeutic interventions targeting apoptosis. -
Caspase-2 Substrate
Ac-VDVAD-pNA is a specific substrate for caspase-2, designed to facilitate the assessment of caspase-2 activity in various biological samples. This reagent releases a chromogenic product upon cleavage by active caspase-2, making it useful for both in vitro and in vivo studies. It serves as a vital tool in research applications focused on apoptotic pathways and caspase-related signaling mechanisms. -
Apoptosis Inducer
Euptox A (9-Oxo-10, 11-dehydroageraphorone) is a potent apoptosis inducer derived from the cadenine sesquiterpene found in Eupatorium adenophorum. It enhances the expression of apoptotic proteases, particularly caspase-10, in HeLa cells, leading to increased apoptotic activity. This compound is valuable for research into apoptosis mechanisms and potential therapeutic applications in cancer treatment. -
Apoptosis Inducer
MT-21 is an apoptosis inducer that functions as an inhibitor of adenine nucleotide translocase. It triggers apoptosis by activating c-Jun N-terminal kinase (JNK) through the Krs/MST signaling pathway and facilitates the activation of caspase-3 via caspase-9. Additionally, MT-21 promotes the release of cytochrome c from mitochondria, making it a valuable reagent for investigating tumor biology and apoptotic mechanisms in cancer research. -
Apoptosis Inducer
SM1044 is a dihydroartemisinin (DHA) dimer that serves as an apoptosis inducer. It activates caspase pathways to effectively trigger apoptosis in RL95-2 and KLE cancer cell lines. Additionally, SM1044 demonstrates potent antiproliferative activity, with IC50 values below 3.6 μM across multiple cancer cell lines, including HEC-50, HEC-1-A, HEC-1-B, and AN3CA. Furthermore, SM1044 has been shown to inhibit tumor growth in RL95-2 xenograft mouse models, highlighting its potential utility in cancer research. -
Caspase 3 Inhibitor, GSDME Inhibitor
Ac-DMLD-CMK is a potent inhibitor of caspase 3 and GSDME, functioning by binding directly to the catalytic domain of caspase-3. This compound effectively obstructs caspase-3-mediated cleavage of GSDME, thereby modulating the caspase 3-GSDME signaling pathway. Its primary biological activity includes the reduction of pyroptosis and apoptosis, as well as the suppression of inflammatory cytokines such as LDH, IL-6, IL-1β, and IL-18. Ac-DMLD-CMK shows potential in mitigating renal function decline, renal tubular epithelial cell damage, and chemotherapeutic nephrotoxicity. -
Apoptosis Inducer
Ly101-4B is an apoptosis inducer that primarily targets the regulation of key proteins involved in cell survival and proliferation. It exhibits significant antiproliferative and cytotoxic effects by reducing HSF1 expression and inhibiting microRNA-214 synthesis, leading to the downregulation of HSP27, HSP70, and HSP90. Additionally, Ly101-4B activates caspase 3/7-mediated apoptosis by impairing DNA synthesis and disrupting the cell cycle at the G1/S phase transition, while sparing RNA synthesis and avoiding necrosis. This compound is particularly effective against pancreatic ductal adenocarcinoma cells with distinct genotypes and levels of E2F dependence, making it valuable for research in epithelial ovarian cancer and pancreatic ductal adenocarcinoma. -
Apoptosis Inducer
Antitumor agent-72 is a potent apoptosis inducer targeting key apoptotic pathways. This compound effectively activates caspase-3 and induces PARP cleavage, leading to significant anticancer activity. Antitumor agent-72 is suitable for studies related to cancer research and the exploration of apoptosis mechanisms. -
Thioredoxin-Caspase 3 Disruptor
KEA1-97 is a selective disruptor of the thioredoxin-caspase 3 interaction, exhibiting an IC50 of 10 μM. This compound effectively disrupts the binding of thioredoxin to caspase 3, leading to the activation of caspases and subsequent induction of apoptosis, while preserving thioredoxin's enzymatic function. KEA1-97 is valuable for research into apoptosis mechanisms and therapeutic strategies targeting cell death pathways. -
Caspase-1 Inhibitor
CZL80 is a potent caspase-1 inhibitor with an IC50 of 0.01 μM, capable of penetrating the blood-brain barrier. This compound is valuable for studying inflammatory pathways in neurological disorders, notably in the context of febrile seizures and their correlation with increased susceptibility to epilepsy. Research applications include investigating the role of caspase-1 in neuroinflammation and other brain-related pathologies. -
Apoptosis Inducer
3-Methoxy-9H-Carbazole is a potent apoptosis inducer that primarily targets caspase-3 activity. This compound enhances the generation of reactive oxygen species, leading to the inhibition of cancer cell proliferation and the initiation of apoptotic pathways. Its biological activity makes it a valuable tool for research into cancer mechanisms and apoptosis-related studies. -
Caspase-1 Fluorogenic Substrate
Ac-Trp-Glu-His-Asp-AMC is a specific fluorogenic substrate designed for caspase-1 detection and activity measurement. This compound exhibits high sensitivity and selectivity for caspase-1, enabling the quantitative assessment of apoptotic processes and inflammatory pathways. Its application in fluorescence assays facilitates the study of caspase-1's role in various biological contexts, including immune responses and cell death mechanisms. -
p53 Inhibitor
p-nitro-Pifithrin-α is a potent inhibitor of the p53 tumor suppressor protein. This cell-permeable compound effectively suppresses p53-mediated TGF-β1 expression in HK-2 kidney cells and prevents the activation of caspase-3 induced by Zika virus strains. Additionally, p-nitro-Pifithrin-α demonstrates protective effects against steatosis and liver injury in high-fat diet models, positioning it as a valuable tool in the study of non-alcoholic fatty liver disease and p53-related pathways. -
RIPK3 Inhibitor
RIPK3-IN-4 is a potent inhibitor of receptor-interacting protein kinase 3 (RIPK3), primarily known for its role in necroptosis and inflammation. This compound effectively protects HK-2 cells from damage, mitigating necroptosis and inflammatory responses. Additionally, RIPK3-IN-4 demonstrates significant protective effects against kidney damage induced by Cisplatin and ischemia/reperfusion, making it a valuable tool for research into acute kidney injury and related inflammatory conditions. -
RIPK3 Inhibitor
RIPK3-IN-6 is a type I inhibitor targeting Receptor-Interacting Serine/Threonine Kinase 3 (RIPK3), known for its role in programmed necrosis and inflammation. This compound exhibits poor selectivity across the RIPK family, particularly affecting the activity of RIPK2. It serves as a valuable tool for investigating necroptosis pathways and their implications in various diseases, providing insights into signaling processes and therapeutic targets. -
RIPK1 Inhibitor
SZM-1209 is a potent and specific inhibitor of RIPK1, demonstrating a Kd of 85 nM. It exhibits significant anti-necroptotic activity with an EC50 value of 22.4 ± 8.1 nM. SZM-1209 has been shown to mitigate conditions associated with systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI), making it a valuable tool for research in inflammation-related pathologies. -
Granzyme B/Caspase-8 Substrate
Z-IETD-pNA is a specific substrate for caspase-8 and granzyme B, designed for colorimetric detection. Upon hydrolysis by caspase-8, this compound releases para-nitroaniline (pNA), facilitating the measurement of enzyme activity. It is widely utilized in research applications focusing on apoptosis and immune responses, enabling the study of cell death mechanisms and the role of granzyme B in cytotoxicity. -
Caspase Like Protease Inhibitor
Ac-YVAD-FMK is a selective inhibitor of caspase 1-like proteases. It functions by covalently modifying the active site cysteine, thus blocking the enzymatic activity of these proteases. This compound is valuable in the study of inflammation and cell death pathways, particularly in research focused on the mechanisms of pyroptosis and other caspase-associated processes. -
Caspase Inhibitor
Z-LEED-FMK is a selective inhibitor of caspase-4 and caspase-13. This compound effectively inhibits the processing of caspase-1 in macrophages infected with S. typhimurium, making it a valuable tool for studying apoptosis and inflammatory pathways. Its specificity and inhibitory effects are significant for research applications in cell death mechanisms and inflammatory response investigations. -
Caspase Activator
15-Acetoxyscirpenol is a potent caspase activator that induces apoptosis through the activation of multiple caspases, with effects that are independent of caspase-3. This mycotoxin significantly inhibits the growth of Jurkat T cells in a dose-dependent manner. Its ability to modulate apoptosis makes it a valuable tool for research in cancer biology and cell signaling pathways. -
Caspase 8 Inhibitor
Boc-AEVD-CHO is a selective inhibitor of Caspase 8, a crucial enzyme involved in apoptotic pathways. This compound is valuable for investigating the mechanisms of apoptosis as well as the roles of Caspase 8 in various immune and inflammatory diseases. Researchers can utilize Boc-AEVD-CHO to better understand cellular processes related to programmed cell death and inflammation regulation. -
Caspase-1 Substrate
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a substrate specifically designed for caspase-1 activity. This compound is pivotal in studying inflammation and cell death pathways, as it is cleaved by caspase-1 during the activation of inflammatory caspases. Z-YVAD-pNA serves as an essential tool in research focused on apoptosis, pyroptosis, and other caspase-related signaling mechanisms. Its use can aid in the development of therapeutic strategies targeting inflammatory diseases. -
Caspase-1 Substrate
Ac-VAD-pNA is a synthetic substrate specifically designed for the detection of caspase-1 activity. This compound enables the assessment of caspase-1 enzymatic function, making it a valuable tool for studying apoptotic and inflammatory pathways. Its utility in various research applications includes investigating mechanisms of cell death and inflammatory responses, facilitating advancements in therapeutic strategies targeting these processes. -
Caspase-3 Fluorogenic Substrate
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate specifically designed for the quantification of caspase-3 activity. Utilizing the caspase-3 recognition sequence DEVD, this substrate facilitates the detection of caspase-3-mediated apoptosis in various biological samples. It is widely applied in research focused on programmed cell death and can be utilized in high-throughput screening assays to evaluate the efficacy of anti-apoptotic and pro-apoptotic compounds. -
Caspase 3 Inhibitor
Cimiside E, a caspase 3 inhibitor, is a triterpene xyloside known for its pro-apoptotic effects on gastric cancer cells, displaying an IC50 value of 14.58 μM. This compound induces cell cycle arrest in the G2/M phase and mediates apoptosis via activation of the caspase cascade across both extrinsic and intrinsic pathways. Cimiside E is a valuable tool in cancer research, particularly in studies focusing on apoptosis and cell cycle modulation. -
Caspase-8 Inhibitor
IETD-CHO is a selective inhibitor of caspase-8, a crucial enzyme in the apoptotic signaling pathway. By blocking caspase-8 activity, this reagent prevents the activation of downstream effector caspases, allowing for the study of programmed cell death mechanisms. IETD-CHO is widely used in research applications focused on apoptosis, inflammation, and related cell signaling processes.
