AV123 is a potent RIPK1 inhibitor with an IC50 of 12.12 µM. This non-cytotoxic compound effectively blocks TNF-α-induced necroptosis, exhibiting an EC50 of 1.7 µM, while leaving apoptotic pathways unaffected. AV123 is valuable for investigating necrotic conditions, including ischemia-reperfusion injuries in the brain, heart, and kidney, as well as in various inflammatory and neurodegenerative diseases.
AV123 is a potent RIPK1 inhibitor with an IC50 of 12.12 µM. This non-cytotoxic compound effectively blocks TNF-α-induced necroptosis, exhibiting an EC50 of 1.7 µM, while leaving apoptotic pathways unaffected. AV123 is valuable for investigating necrotic conditions, including ischemia-reperfusion injuries in the brain, heart, and kidney, as well as in various inflammatory and neurodegenerative diseases.
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