RIPK1-IN-17 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1) with a Kd of 17 nM, exhibiting minimal activity against RIPK3. This compound specifically targets necroptosis by inhibiting the phosphorylation of RIPK1, RIPK3, and MLKL, thereby preventing necroptotic cell death while allowing apoptosis to proceed. RIPK1-IN-17 has demonstrated protective effects in mice against hypothermia and mortality, making it a valuable tool for researching necroptosis-related conditions, particularly in the context of inflammatory response syndrome (SIRS).
RIPK1-IN-17 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1) with a Kd of 17 nM, exhibiting minimal activity against RIPK3. This compound specifically targets necroptosis by inhibiting the phosphorylation of RIPK1, RIPK3, and MLKL, thereby preventing necroptotic cell death while allowing apoptosis to proceed. RIPK1-IN-17 has demonstrated protective effects in mice against hypothermia and mortality, making it a valuable tool for researching necroptosis-related conditions, particularly in the context of inflammatory response syndrome (SIRS).
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