7α,24(S)-Dihydroxycholesterol is an endogenous metabolite that functions as a selective ligand for liver X receptors (LXR), specifically binding to the ligand binding domains of both LXRα and LXRβ. This compound plays a significant role in cholesterol metabolism and homeostasis, making it valuable for research applications in lipid biology and metabolic disorders. Its synthesis involves a series of transformations starting from E-α,β-enone and using Arsonium ylide and J-tert-butyldimethylsilyloxy-bisnor-5-cholenaldehyde.
7α,24(S)-Dihydroxycholesterol is an endogenous metabolite that functions as a selective ligand for liver X receptors (LXR), specifically binding to the ligand binding domains of both LXRα and LXRβ. This compound plays a significant role in cholesterol metabolism and homeostasis, making it valuable for research applications in lipid biology and metabolic disorders. Its synthesis involves a series of transformations starting from E-α,β-enone and using Arsonium ylide and J-tert-butyldimethylsilyloxy-bisnor-5-cholenaldehyde.
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