12-Oxo-leukotriene B4 is an endogenous metabolite and an important intermediate in the lipoxygenase-catalyzed metabolism of arachidonic acid. This compound plays a crucial role in the biosynthesis of leukotriene B4 and is involved in inflammatory responses. It stimulates intracellular calcium levels in human neutrophils with an EC50 of 33 nM and promotes neutrophil migration with an EC50 of 170 nM. Its biological activity makes it a valuable tool for research in inflammation and immune response studies.
12-Oxo-leukotriene B4 is an endogenous metabolite and an important intermediate in the lipoxygenase-catalyzed metabolism of arachidonic acid. This compound plays a crucial role in the biosynthesis of leukotriene B4 and is involved in inflammatory responses. It stimulates intracellular calcium levels in human neutrophils with an EC50 of 33 nM and promotes neutrophil migration with an EC50 of 170 nM. Its biological activity makes it a valuable tool for research in inflammation and immune response studies.
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